Tag Archives: type

Scientists propose breast cancer drug for bladder cancer patients

As with breast cancer, HER2 amplification in MPUC results in a faster growing form of cancer that spreads quickly and has a higher chance of recurrence. The hope is that combating this amplification with trastuzumab, a drug that is effective in HER2 positive breast cancers, will result in effective therapy against bladder cancer. "These findings show it is critical for pathologists to recognize this type of bladder cancer and that providers should be aware of and order the appropriate tests," says John Cheville, M.D., a Mayo Clinic pathologist and lead author of the study. …

Genetic flaw in males triggers onset of liver cancer, diabetes

The research, published in the online issue of Cancer Cell, found that when the NCOA5 gene, present in both men and women, was altered in male mice to a deficient level, a spontaneous reaction occurred producing cells that can lead to hepatocellular carcinoma, a type of liver cancer found to be two-to-four times more prevalent in men than women. Findings also showed that prior to cancer development there were occurrences of glucose intolerance, a prediabetic condition that is believed to increase the risk of type 2 diabetes in humans. …

Group of anti-diabetic drugs can lower cancer risk in women with type 2 diabetes

People with type 2 diabetes have a higher rate of cancer development and recurrence compared to the general population. This study — published online by the journal Diabetes, Obesity and Metabolism — shows that widely prescribed anti-diabetes drugs can be linked to either an increased or decreased risk of cancer, depending on the type of medication prescribed. A team of researchers led by Sangeeta Kashyap, M.D., an endocrinologist and associate professor of medicine at Cleveland Clinic’s Endocrinology & Metabolism Institute, compared two groups of drugs commonly used to treat type 2 diabetes — insulin sensitizers and insulin secretagogues…

Pills of the future: Nanoparticles; Researchers design drug-carrying nanoparticles that can be taken orally

Now, researchers from MIT and Brigham and Women’s Hospital (BWH) have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections. In a paper appearing in the Nov. 27 online edition of Science Translational Medicine, the researchers used the particles to demonstrate oral delivery of insulin in mice, but they say the particles could be used to carry any kind of drug that can be encapsulated in a nanoparticle…

Chronic diseases hinder good cancer survival rates

How much diseases such as diabetes, COPD (chronic obstructive pulmonary disease), arthritis, depression and cardiovascular disease mean for cancer survival depends on the type of cancer; but the overall picture is the same. Other diseases have a strong negative impact on both the one and five-year survival rate. For example, for breast cancer the five-year survival rate for patients without other diseases is 83 percent. For patients with one or two other chronic diseases the survival rate is 64 percent, while it is 50 percent for those with three or more diseases. …

Triple-negative breast cancer target for drug development identified

UCSF researcher Luika Timmerman, PhD, an investigator in the UCSF Helen Diller Family Comprehensive Cancer Center, found that many cell lines obtained from triple-negative breast cancer are especially dependent on cystine, one of the 20 amino acids that are the building blocks of proteins that all cells need. Timmerman used an FDA-approved drug to inhibit activity of a transporter protein that ferries cystine into triple-negative breast cancer cells, and found that it significantly inhibited their growth in culture and when the cancer cells were transplanted into mice…

Technique to promote nerve regeneration after spinal cord injury restores bladder function in rats

For decades, scientists have experimented with using nerve grafts as a way of bridging the spinal cord injury site in an attempt to recover lost function following spinal cord injury. However, coaxing these cells to grow and form connections capable of relaying nerve signals has been elusive. In the current study, Yu-Shang Lee, PhD, of the Cleveland Clinic, together with Jerry Silver, PhD, of Case Western Reserve Medical School, and others, used a chemical that promotes cell growth along with a scar-busting enzyme to create a more hospitable environment for the nerve graft at the injury site. …

Statins reduce cardiovascular events in coronary artery disease patients with very low LDL cholesterol levels

Dr Nakano said: "Many randomised clinical trials, such as Treating to New Targets (TNT) and PROVE IT-TIMI, have shown that aggressive cholesterol lowering with statins improves clinical outcomes in patients with CAD and high LDL-C levels.1,2 But until now it was not known whether aggressive lipid lowering with statins would also benefit CAD patients with very low LDL-C levels." The current study used the Ibaraki Cardiovascular Assessment Study (ICAS), a registry of 2,238 patients from 12 hospitals in the Ibaraki region of Japan, who between 0 and 1 month underwent percutaneous coronary interventions. Based on serum LDL-C levels at initial presentation participants were classified into three groups: very low (<70 mg/dl, n=214); low (71-100 mg/dl, n=669); and high (>101 mg/dl, n= 1,355). Decisions of whether to prescribe statins or not, as well as the type and dose, were left to the discretion of treating physicians…