Tag Archives: team

Novel compound prevents metastasis of multiple myeloma in mouse studies

The research involves a new approach to the challenge of cancer metastasis, the process by which tumors spread to and colonize distant parts of the body. Whereas research has traditionally focused on cancer cells themselves, scientists are increasingly studying the interactions between tumor cells and the tissues around them — the so-called microenvironment. …

How the ends of chromosomes are maintained for cancer cell immortality — ScienceDaily

Telomeres stay intact in most cancer cell types by means of a specialized enzyme called telomerase that adds the repetitive telomere DNA sequences to the ends of chromosomes. Cancer cells can also use a second method involving a DNA-repair-based mechanism, called alternative lengthening of telomeres, or ALT for short. In general, cancer cells take over either type of telomere maintenance machinery to become immortal…

Gene that increases incidence of acute myelogenous leukaemia discovered

Led by Associate Professor Chng Wee Joo, Deputy Director and Senior Principal Investigator at CSI Singapore and Director of the National University Cancer Institute, Singapore, the scientists discovered that inhibition of Leo1 and Leo1 downstream signalling pathways provide an avenue for targeted treatment of AML. The findings were recently published in Cancer Research, the official journal of the American Association of Cancer Research. …

Wireless sensor transmits tumor pressure

Contents under Pressure Tumors, like healthy tissues, need oxygen and nutrients to survive. In order to accommodate the demands of a growing tumor, blood vessels from surrounding tissue begin to grow into the tumor. Yet, unlike normal tissue, these newly formed blood vessels are disorganized, twisty, and leaky. It’s thought that the high pressure observed in tumors is a result of these abnormal blood vessels, which leak fluid and proteins into the area between tumor cells, known as the interstitial space…

Wild berry extract may strengthen effectiveness of pancreatic cancer drug

The study by researchers at King’s College Hospital and the University of Southampton suggests that adding nutraceuticals to chemotherapy cycles may improve the effectiveness of conventional drugs, particularly in hard to treat cancers, such as pancreatic cancer. The team tested the effectiveness of extract of chokeberry (Aronia melanocarpa) in killing off cancer cells, probably by apoptosis (programmed cell death) as markers of early apoptosis appear in treated cells. Chokeberry is a wild berry that grows on the eastern side of North America in wetlands and swamp areas. The berry is high in vitamins and antioxidants, including various polyphenols-compounds that are believed to mop up the harmful by-products of normal cell activity. …

Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer? — ScienceDaily

The results, which Fox Chase researchers presented at the American Society for Radiation Oncology’s 56th Annual Meeting on September 14, suggest that low-risk patients over 65 years old with small tumors may achieve comparable survival after treatment with adjuvant radiation therapy alone — without undergoing endocrine therapy. …

Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer?

The results, which Fox Chase researchers presented at the American Society for Radiation Oncology’s 56th Annual Meeting on September 14, suggest that low-risk patients over 65 years old with small tumors may achieve comparable survival after treatment with adjuvant radiation therapy alone — without undergoing endocrine therapy. “When they’re treated with adjuvant radiation therapy alone, elderly women with small, low risk tumors may have acceptable results,” says Colin T. …

Study identifies when and how much various prostate cancer treatments will impact urinary and sexual functioning

Looking over data gathered from more than 17,000 surveys completed by men diagnosed with prostate cancer, Fox Chase researchers tracked when patients’ urinary and sexual symptoms changed following each type of treatment, and by how much. “The ultimate goal,” says study author Matthew Johnson, MD, Resident Physician in the Department of Radiation Oncology at Fox Chase, “is to develop a predictive tool that lets patients decide which treatment is right for them based on the symptoms they have beforehand, and their tolerance for any change — even temporary — in those symptoms.” After a diagnosis of prostate cancer, men have multiple treatment options, including surgery to remove the prostate and several types of radiation therapy. They can receive external beam radiation directed towards their prostate, known as intensity modulated radiation therapy (IMRT), or undergo a procedure that implants radioactive seeds in their prostate called low dose rate brachytherapy (LDR). …