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New minimally invasive test identifies patients for Barrett’s esophagus screening

To evaluate the safety, acceptability, and accuracy of the minimally invasive test compared with endoscopy for the diagnosis of Barrett’s esophagus, the researchers enrolled 1110 individuals attending 11 UK hospitals for investigational endoscopy of dyspepsia and reflux symptoms. They found that the new test correctly identified 79.9% of the 647 individuals with endoscopically diagnosed Barrett’s esophagus, and that 92.4% of 463 individuals unaffected by Barrett’s esophagus were correctly identified as being unaffected. The sensitivity of the test increased to 87.2% for patients with circumferential Barrett’s segments more than 3 cm, which are known to confer a higher cancer risk. Nearly 94% of the participants swallowed the sampling device (Cytosponge) successfully, there were no adverse effects attributed to the device, and participants who swallowed the device generally rated the experience as acceptable…

The secret life of anti-cancer drugs

But what happens to these drugs? When do they become accessible to cancer patients — if at all? In a new review published in ecancermedicalscience, researchers trace the journey anti-cancer drugs take between discovery and clinical practice. “Bringing a new medication to clinical practice is a lengthy process and involves many stakeholders with a very diverse background, ranging from researchers, regulatory agencies, payers, physicians and patients,” says Dr Felipe Ades of the Jules Bordet Institute, lead author of the review…

Focus on treatment costs, value: Less radiation for elderly women with early breast cancer — ScienceDaily

The study, using a national database of more than 100,000 women treated during the last decade, found that today nationally radiation oncologists are less likely to use radiotherapy in women older than 70 with early-stage estrogen-receptor-positive breast cancer and that when they do, treatment is appropriately less-intensive. This follows a randomized trial demonstrating low rates of recurrence in women who don’t receive radiotherapy after lumpectomy, provided they take endocrine therapy. This confirms radiation oncologists are responding to a growing impetus to keep medical practices current and cost-effective, said first author Charles Rutter, M.D., a radiation oncology resident in Yale’s School of Medicine. …

Surgery associated with better survival for patients with advanced laryngeal cancer

Approximately 11,000 to 13,000 cases of laryngeal cancer are diagnosed each year and squamous cell carcinoma accounts for the vast majority of these tumors. Prior to 1991, total surgical removal of the larynx with postoperative radiation was the standard of care for advanced cancer. Since then, chemoradiation has become increasingly popular treatment because it can preserve the larynx. The authors evaluated survival outcomes for surgical vs. …

Less radical procedures offer similar cancer control compared to surgery for kidney cancer patients

Dr. Thompson says radical nephrectomy — surgical removal of the entire kidney — has historically been the standard of care for management of kidney cancer; however, partial nephrectomy — surgical removal of tumors from a kidney while sparing healthy tissue -has become increasingly more common because of its nephron-sparing benefits and similar cancer control…

Rare form of tongue cancer suggests screening vigilance

A 65-year-old male patient with a history of chronic alcoholism complained of an odd, painless white growth over his tongue. Doctors at the Government Medical College in Latur, India were intrigued when they identified the hard white growth as a rare case of spindle cell carcinoma. Spindle cell carcinoma is an aggressive variant of squamous cell carcinoma. These tumors get their name from their distinctive spindle-shaped cells, readily detectable by immunohistochemistry…

Saving the heart in breast cancer treatment — ScienceDaily

Breast cancer patients who are positive for the HER2 gene may be at increased risk for heart damage during chemotherapy, according to a new study published in ecancermedicalscience. Patients with the HER2 gene are often treated with trastuzumab or lapatinib, which interfere with its cancer-causing signals…