Tag Archives: sciences

Study questions anti-cancer mechanisms of drug tested in clinical trials

But new research appearing the week of Jan. 13 in Proceedings of the National Academy of Sciences (PNAS) suggests that activation of AMPK may actually fuel cancer growth. Researchers from Cincinnati Children’s Hospital Medical Center who led the study also recommend that clinicians testing metformin for cancer treatment consider a careful re-evaluation of their clinical data. The researchers report on extensive laboratory tests that conclude metformin does stop cancer, although not by activating AMPK…

Researchers develop tool to determine individual risk of prostate cancer overdiagnosis

Now, researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a personalized tool that can predict the likelihood of prostate cancer over-diagnosis. They announced their findings this week in the online issue of the Journal of the National Cancer Institute…

Research reveals structure of master regulator, new drug target for autism, cervical cancer

"Because the assembly of cells is like an elaborate tinker toy set in which the parts can be used in different combinations to serve various roles, E6AP normally functions in nerve cells to direct brain development and in a functionally related process termed neuronal plasticity which allows nerve cells to alter their patterns of communication with neighboring cells during learning," notes Arthur Haas, PhD, the Roland Coulson Professor and Chairman of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and Director of the laboratory in which the work was performed. The research team included lead investigator Dr. Virginia Ronchi, a postdoctoral fellow, and her colleagues, Jennifer Klein and Dr. Daniel Edwards, all of whom work in Dr…

New cell mechanism discovery key to stopping breast cancer metastasis

"Genetic mutations do not drive this mechanism," said Alana Welm, PhD, senior author of the study, associate professor in the Department of Oncological Sciences, and an investigator at Huntsman Cancer Institute. "Instead, it’s improper regulation of when genes turn on and off." The new discovery focuses on a protein called RON kinase (RON), which signals some areas of tumor cell DNA to become active…

Scientists make advance in cancer research

The most advanced version of vβ3-integrin antagonists failed clinical trials to treat aggressive forms of brain cancer. But research published today in the American Heart Association’s journal Circulation Research shows that targeting the protein in question could still be vital in stopping the growth of tumors. Not least because the drugs targeting it cause minimal side effects compared to other drugs — which can cause bleeding in the gut and high blood pressure. tumors must recruit their own blood supply to grow beyond a very small size…

New research to help care for breast cancer patients in their homes

Senior Research Fellow Dr Collin Sones and Professor Rob Eason are working with colleagues from Medicine and the Institute of Life Sciences — Dr Spiros Garbis, Professor Peter Smith and Professor Saul Faust — to develop laser-printed paper-based sensors that can be used to detect biomarkers in cancer patients and see how they are responding to their chemotherapy treatment. …