Tag Archives: school

Lab-grown, virus-free stem cells repair retinal tissue in mice

In a report published Jan. 20 in the journal Circulation, stem cell biologist Elias Zambidis, M.D., Ph.D., and his colleagues describe laboratory experiments with these non-viral, human retinal iPSCs, created using the virus-free method Zambidis first reported in 2011. "We began with stem cells taken from cord-blood, which have fewer acquired mutations and little, if any, epigenetic memory, which cells accumulate as time goes on," says Zambidis, associate professor of oncology and pediatrics at the Johns Hopkins Institute for Cell Engineering and the Kimmel Cancer Center. The scientists converted these cells to a status last experienced when they were part of six-day-old embryos. …

Team discovers key mechanisms to inhibit triple negative breast cancers

“In previous findings published over the past 10 years, our teams have described key mechanisms in these critical proteins,” said Khalid Sossey-Alaoui, PhD, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic. “A key component in the deadly metastatic potential of TNBC tumors is that they spread through tissues outside the breast very quickly. The two proteins that we studied, WAVE3 and TGF-β, when together, promote tumor aggressiveness.” “We found important biological implications,” said William Schiemann, PhD, an associate professor, Division of General Medical Sciences-Oncology, Case Western Reserve School of Medicine, and co-leader of the Breast Cancer Program at the Case Comprehensive Cancer Center…

Phase II trial of Bevacizumab (Svastin) in locally advanced cervical cancer found ‘promising’

"Cervical cancer is a huge problem worldwide, but isn’t as big a problem in the United States. So in many ways it tends to become a somewhat overlooked and under-studied disease," says Tracey Schefter, MD, investigator at the University of Colorado Cancer Center, director of the Stereotactic Body Radiation Therapy program at the University of Colorado School of Medicine, and the study’s lead author…

Cervical screening up to age 69 may prevent cervical cancer in older women

Peter Sasieni and colleagues, from Queen Mary University of London, UK, examined the link between screening women aged 50 to 64 for cervical cancer and cervical cancer diagnosed at ages 65 to 83. Their study included all 65 to 83-year old women in England and Wales diagnosed with cervical cancer between 2007 and 2012, a total of 1,341 women. …

New analysis shows fewer years of life lost to cancer

"We have made steady progress against the burden of many cancers for decades," said principal investigator Samir Soneji, PhD, assistant professor for Geisel School of Medicine at Dartmouth and the Dartmouth Institute for Health Policy and Clinical Practice, a member of Norris Cotton Cancer Center. "As fewer and fewer people die from heart disease, stroke, and accidents, more and more people are alive long enough to be at risk of developing and dying from cancer." Between 1970 and 2008, mortality rates from heart disease, cerebrovascular disease, and accidents declined 62 percent, 73 percent, and 38 percent, respectively. In the same period, cancer mortality rates declined just 12 percent…