Tag Archives: oncology

Two behavioral interventions help cancer patients struggling with sleep issues

"Insomnia and disturbed sleep are significant problems that can affect approximately half of all cancer patients," said lead study author Sheila Garland, PhD, a Clinical Psychology Post-Doctoral Fellow at Penn’s Abramson Cancer Center in Integrative Oncology and Behavioral Sleep Medicine. "If not properly addressed, sleep disturbances can negatively influence therapeutic and supportive care measures for these patients, so it’s critical that clinicians can offer patients reliable, effective, and tailored interventions." Estimates suggest that anywhere between 36 to 59 percent of patients with cancer experience disturbed sleep and insomnia symptoms during and after the completion of cancer treatment, with up to 28 percent meeting a formal diagnosis of insomnia. While there are effective drugs that can help treat insomnia, Garland says that many cancer patients express a desire not to take additional medications due to concerns about side effects and the possibility of developing a dependence on the medication. The new study involved 111 cancer patients recruited from a cancer center in Calgary, Alberta, Canada, to one of two randomly assigned interventions for their insomnia, either CBT-I (47) or MBSR (64)…

Younger, early breast cancer patients often undergo unnecessary staging, imaging procedures

Presented at a poster session at the 2013 CTRC-AACR San Antonio Breast Cancer Symposium by Carlos Barcenas, M.D., assistant professor in MD Anderson’s Breast Medical Oncology, the study is the first to look at the issue of over-use of staging procedures, including imaging and tumor markers in the diagnosis setting, specifically in younger, early-stage breast cancer patients. Over-testing and unnecessary procedures extends beyond cancer care across the healthcare continuum. …

Cancer-promoting protein is vital to safe division of tumor cells

In a paper published in Molecular Cell, Zhimin Lu, Ph.D., professor of Neuro-Oncology at The University of Texas MD Anderson Cancer Center and colleagues report how a tumor-specific protein flips a crucial switch in an irregular mechanism for mitosis that allows cancer cells to safely divide. "Our research shows that tumor cells rely heavily on a distinct mechanism for orderly cell division that’s driven by oncogene-induced pyruvate kinase M2," Lu said. After a cell begins division by replicating all of its chromosomes, mitosis separates them into two identical sets of chromosomes for both cells. After mitosis, cytokinesis completes cell divison. …

Protein in prostate biopsies signals increased cancer risk

Their findings, reported in the Journal of Clinical Oncology, are the first to quantify, in the setting of a clinical trial, the increased risk of prostate cancer development from the protein ERG. Traditional means of determining risk of prostate cancer — blood tests for the protein prostate-specific antigen (PSA) and biopsies — do not always correlate well with the chances of dying from the disease. Decisions on what to do with the results of these tests can be unclear, leaving doctors and patients frustrated and unsure of how to proceed. …

Untreated cancer pain a ‘scandal of global proportions,’ survey shows

The results from the Global Opioid Policy Initiative (GOPI) project show that more than 4 billion people live in countries where regulations leave cancer patients suffering excruciating pain. National governments must take urgent action to improve access to these medicines, says the European Society for Medical Oncology, leader of a group of 22 partners that have launched the first global survey to evaluate the availability and accessibility of opioids for cancer pain management. "The GOPI study has uncovered a pandemic of over-regulation in much of the developing world that is making it catastrophically difficult to provide basic medication to relieve strong cancer pain," says Nathan Cherny, Chair of the ESMO Palliative Care Working Group and lead author of the report, from Shaare Zedek Medical Center, Jerusalem, Israel. "Most of the world’s population lacks the necessary access to opioids for cancer pain management and palliative care, as well as acute, post-operative, obstetric and chronic pain." "When one considers that effective treatments are cheap and available, untreated cancer pain and its horrendous consequences for patients and their families is a scandal of global proportions," Cherny says…

Cancer patients at increased risk for severe flu complications

"The flu shot is recommended annually for cancer patients, as it is the most effective way to prevent influenza and its complications," said Mollie deShazo, M.D., associate professor of Medicine in the Division of Hematology and Oncology and medical director of UAB Inpatient Oncology. "The flu vaccine significantly lowers the risk of acquiring the flu; it is not 100 percent effective, but it is the best tool we have." Flu activity in the United States is low, even after increasing slightly in recent weeks, according to the Centers for Disease Control and Prevention. However, more activity is expected, and people who have not had a flu vaccine this year are advised to do so. "It takes up to two weeks to build immunity after a flu shot, but you can benefit even if you get the vaccine after the flu has arrived in your community," deShazo said…

Imaging studies may predict tumor response to anti-angiogenic drugs

"Two recent phase III trials of another anti-angiogenic drug, bevacizumab, showed no improvement in overall survival for glioblastoma patients, but our study suggests that only a subset of such patients will really benefit from these drugs," explains Tracy Batchelor, MD, director of the Pappas Center for Neuro-Oncology at the MGH Cancer Center and co-lead and corresponding author of the current study. "Our results also verify that normalization of tumor vasculature appears to be the way that anti-angiogenic drugs enhance the activity of chemotherapy and radiation treatment." Anti-angiogenic drugs, which block the action of factors that stimulate the growth of blood vessels, were first introduced for cancer treatment under the theory that they would act by ‘starving’ tumors of their blood supply…

Quality of care improves for cancer patients who get palliative care consultation

Palliative care is the medical specialty that focuses on improving quality of life for patients and their families in the setting of a serious illness. Palliative care teams provide an added layer of support to patients, caregivers, and doctors by addressing unremitting symptoms, helping with decision making, and coordinating care. The American Society of Clinical Oncology (ASCO) selected a total of four high-impact abstracts, including this one, to feature in an official press briefing for its upcoming 2013 Quality Care Symposium. More than 270 abstracts will be presented at the conference, which will be held in San Diego on November 1-2…