Breast cancer is the most common form of cancer in women, and metastasis is a major cause of health deterioration and death from the disease. Management of metastasis is difficult for several reasons…
Such a theory was first proposed as an explanation for metastasis more than a century ago. But until now, the theory was unproven in human cancer because genomic differences between cells from the same patient cannot be distinguished…
Led by Lenore Arab, PhD, JCCC member and professor in the departments of medicine and biological chemistry, the researchers examined associations between adherence to WCRF recommendations and risk of highly aggressive prostate cancer among subjects enrolled in the North Carolina-Louisiana Prostate Cancer Project. …
The new approach is outlined in an article published online by Nature Medicine in May. A previous phase 2 clinical trial showed substantial regression of metastatic lesions in up to 70 percent of melanoma patients who were treated with self-donated tumor-infiltrating lymphocytes. "The trial, which involved the adaptive transfer of a patient’s own immune cells, showed a complete tumor regression lasting at least five years in nearly 40 percent of the patients," Teer said. …
Scientists from Barcelona and London, looked at cells in the neural crest, a very mobile embryonic structure in vertebrates that gives rise to most of the peripheral nervous system and to other cell types in the cardiovascular system, pigment cells in the skin, and some bones, cartilage, and connective tissue in the head. Researchers saw that, during development, these neural crest cells ‘chase’ other types of cells — so-called placodal cells that give rise to the sensory organs — which dash away when approached, thus propelling the cell sheet in a certain direction. "The effect can also be likened to a donkey and carrot effect, with the neural crest cells — the donkey — chasing but never quite reaching the carrot, the placodal cells," explains Xavier Trepat, ICREA Research Professor of the UB and leader of the Research Group on Integrative Cell and Tissue Dynamics of IBEC…
The specific patient populations who appeared to benefit from eribulin, in comparison to capecitabine, are as follows: Patients with more than two organs involved with metastatic breast cancer Patients who had not received chemotherapy for six months or longer Patients who had received anthracycline and/or a taxane therapies in the metastatic setting Previous pre-specified exploratory analysis of overall survival and progression-free survival showed women with triple-negative, ER-negative, HER2-negative also had a greater relative benefit in overall survival with eribulin over capecitabine. …
Researchers from the Department of Public Health at the University of Oxford sought evidence of a decline in population-based breast cancer mortality that could be attributed to the implementation of mammographic screening programmes. They concluded that population-based mortality statistics for England do not show a past benefit of breast cancer screening…
The transformation of sedentary, specialized cells into wandering, invasive, and unspecialized cells is called epithelial-mesenchymal transition (EMT), which is central to metastasis. EMT is a multistage process, which is accompanied by a fundamental change in cell morphology and number of genetic programs. The molecular processes that govern EMT, however, are still poorly understood. Main Switch Found The research groups of Prof. …
Detecting precancerous polyps through the use of imaging techniques such as a traditional colonoscopy may prevent colorectal cancer. …
Nathan Luedtke and colleagues explain that the spread of melanoma and other forms of cancer beyond the original location — a process called metastasis — makes cancer such a serious disease. Photodynamic therapy (PDT), which involves administering a drug that kills cancer cells when exposed to light, already is available. But PDT works only on the main tumor and has other drawbacks. …