Tag Archives: medicine

A simple test may catch early pancreatic cancer

The findings of their research, if confirmed, they say, could be an important step in reducing mortality from the cancer, which has an overall five-year survival rate of less than 5 percent and has seen few improvements in survival over the last three decades. "We have mammograms to screen for breast cancer and colonoscopies for colon cancer but we have had nothing to help us screen for pancreatic cancer," says Nita Ahuja, M.D., an associate professor of surgery, oncology and urology at the Johns Hopkins University School of Medicine and leader of the study described online this month in the journal Clinical Cancer Research. …

Value, limitations of patient assistance programs for women with breast cancer

Most breast cancer patients who had information about patient assistance programs used them to learn more about adjuvant therapy, obtain psychosocial support, and overcome practical/financial obstacles to getting treatment, reported researchers from the Icahn School of Medicine at Mount Sinai. Researchers found that, in most cases, patients who were referred to assistance programs did contact organizations running programs, such as Cancer Care Inc., SHARE, and the Mount Sinai Breast Health Resources Program. …

Lifestyle factors could put college-age women at higher risk of breast cancer

"Unfortunately, college-age women generally do not consider themselves at risk for breast cancer," said Dr. Mercier. "However, there are several risk factors that contribute to the development of breast cancer that need to be understood early in life to prevent the development of breast cancer down the road." By the end of 2013, more than 230,000 new cases of invasive breast cancer are expected to be diagnosed in the U.S…

Staurosporine safely delivered in liposomes

"By itself, staurosporine shows potent activity against a number of cancer cell lines, including chemotherapy-resistant tumors. However, it also harms normal tissue," said senior author Santosh Kesari, MD, PhD, director of neuro-oncology at UC San Diego Moores Cancer Center. "With this study, we have been able to overcome the pharmacokinetic barriers to delivering staurosporine to tumors with the use of liposomes." STS was originally isolated from the bacterium Streptomyces staurosporeus in 1977. The compound prompts a wide variety of cancer cell types to self-destruct, a process called apoptosis or programmed cell death. …

Targeting Cancer’s Sweet Tooth

Published online in Cell Metabolism, the Ludwig Cancer Research study also reveals how the aggressive brain cancer glioblastoma harnesses the mechanism to resist targeted therapies that should disrupt this capability — known as the Warburg effect — and suggests how such resistance might be overcome. In detailing the molecular circuitry of the phenomenon, the researchers uncover several possible targets for new drugs that might disrupt cancer cell metabolism to destroy tumors. "Cancer and other fast-growing cells extract energy from glucose using a process that ordinarily kicks in only when oxygen is in short supply," explains Ludwig scientist Paul Mischel, MD, who is based at the University of California, San Diego School of Medicine…

Scientist uncovers internal clock able to measure age of most human tissues; Women’s breast tissue ages faster than rest of body

While earlier clocks have been linked to saliva, hormones and telomeres, the new research is the first to identify an internal timepiece able to accurately gauge the age of diverse human organs, tissues and cell types. Unexpectedly, the clock also found that some parts of the anatomy, like a woman’s breast tissue, age faster than the rest of the body. "To fight aging, we first need an objective way of measuring it. …

Vitamin D does not contribute to kidney stones

However, a study of 2,012 participants — published in the American Journal of Public Health -found no statistically relevant association between 25-hydroxyvitamin D (25 (OH)D) serum level in the range of 20 to 100 ng/mL and the incidence of kidney stones. This study — led by Cedric F. Garland, DrPH, adjunct professor in the Division of Epidemiology, Department of Family and Preventive Medicine at the University of California, San Diego School of Medicine — used data from the nonprofit public health promotion organization GrassrootsHealth to follow more than 2,000 men and women of all ages for 19 months. …