Universal Tumor Testing Universal genetic testing of the tumors for evidence of mismatch repair (MMR) deficiency of newly diagnosed colorectal cancer patients is recommended for several reasons: 1. Use of clinical criteria and prediction models to identify patients with Lynch syndrome have less than optimal sensitivity and specificity. 2. It has been shown to be cost effective for the diagnosis of Lynch syndrome. …
“The prostate cancer risk calculator has been updated using current risk factors and a better interface; the current version gives a more nuanced result that helps understand a man’s risk of prostate cancer,” said Ian M. …
The drug, known under the brand name Nanotax, is a fine particle reformulation of paclitaxel, the standard treatment for ovarian cancer. …
The effort is known as the Institutional Multidisciplinary Paradigm to Accelerate Collaboration and Translation (IMPACT). The aim — as illustrated in the acronym — is to enhance the way cancer discoveries are translated from the laboratory bench to patient bedside and back again. …
The researchers found that retinoblastoma protein (RB), a protein known to reduce cancer risk, is significantly less active in male brain cells than in female brain cells. The study appears Aug. …
The research involved the intestinal microbiome, which contains some 100 trillion bacteria. The role of these microorganisms in promoting or preventing disease is a major emerging field of study. Einstein scientists found that absorption of a specific bacterial byproduct is crucial for maintaining the integrity of the intestinal epithelium — the single-cell layer responsible for keeping intestinal bacteria and their toxins inside the gut and away from the rest of the body…
The study demonstrates that sunscreen, even with a sun protection factor (SPF) 50, may not fully protect against the development of melanoma. According to the researcher at the UMH Berta López Sánchez-Laorden, sunscreen protects against immediate radiation damage including sunburn, but the radiation can still penetrate and damage the DNA of cells and cause cancer. Through the use of genetically modified mice particularly susceptible to melanoma, the researcher discovered that ultraviolet light causes mutations in the DNA of melanocytes in a gene called p53. …
Researchers say that while most of the viral strains so far appear to be harmless and can remain dormant for years, their overwhelming presence suggests a delicate balancing act for HPV infection in the body, in which many viral strains keep each other in check, preventing other strains from spreading out of control. Although infection is increasingly known to happen through skin-to-skin contact, HPV remains the most common sexually transmitted infection in the United States. It is so common that experts estimate nearly all men and women contract some strain of it during their lives. …
Fibroadenomas are the most common benign breast tumors in women of reproductive age, affecting thousands of women in Singapore each year. …
However, a new Cincinnati Cancer Center (CCC) study, published in the advance online edition of the journal Oncotarget, provides hope that previously studied SapC-DOPS could be used for treatment of brain cancer that has spread. Xiaoyang Qi, PhD, member of the CCC, associate director and associate professor in the division of hematology oncology at the University of Cincinnati (UC) College of Medicine and a member of the UC Cancer and Neuroscience Institutes and the Brain Tumor Center, says this critical data shows promise for finding treatment for one of the deadliest cancers. A lysosomal protein saposin C (SapC), and a phospholipid, known as dioleoylphosphatidylserine (DOPS), can be combined and assembled into tiny cavities, or nanovesicles, to target and kill many forms of cancer cells…