The study demonstrates that sunscreen, even with a sun protection factor (SPF) 50, may not fully protect against the development of melanoma. According to the researcher at the UMH Berta López Sánchez-Laorden, sunscreen protects against immediate radiation damage including sunburn, but the radiation can still penetrate and damage the DNA of cells and cause cancer.
Through the use of genetically modified mice particularly susceptible to melanoma, the researcher discovered that ultraviolet light causes mutations in the DNA of melanocytes in a gene called p53. This is one of the genes considered as guardians of the genome as it is key in detecting and repairing damage that accumulates in cells, such as the produced by ultraviolet light, and is a major barrier of the body against cancer.
Several epidemiological studies have shown an association between sun exposure and the increased risk of melanoma. However, the molecular mechanism that causes this to happen was not clear.
Berta López Sánchez-Laorden is co-author of the work, which has been one of the main projects carried out during her first postdoctoral, developed in the Institute of Cancer Research in London and the Cancer Research UK Manchester Institute.
source : http://www.sciencedaily.com/releases/2014/07/140714100342.htm