Tag Archives: colorectal

Reaching ’80 percent by 2018′ would prevent more than 20,000 colorectal cancer deaths per year

Colorectal cancer (commonly called colon cancer) is the third leading cause of cancer death in both men and women in the United States, and the second leading cause for both sexes combined. An estimated 132,700 new cases and 49,700 deaths are expected in 2015 in the U.S. Data from the past decade show that both incidence and mortality from colon cancer are decreasing at rate of about 3% per year, largely due to the increased use of screening. Still, fewer than six in ten U.S. …

Half of premature colorectal cancer deaths due to socioeconomic inequality

Colorectal cancer (CRC) is the third leading cause of cancer death for both men and women in the U.S. Historically, death rates were higher in those with higher socioeconomic status, in whites, and in northern states. Over the past few decades, though, that switched, with death rates now highest in persons with the lowest socioeconomic status, in blacks, and in southern states…

Long-term colorectal-cancer mortality after adenoma removal

BACKGROUND Although colonoscopic surveillance of patients after removal of adenomas is widely promoted, little is known about colorectal-cancer mortality among these patients. METHODS Using the linkage of the Cancer Registry and the Cause of Death Registry of Norway, we estimated colorectal-cancer mortality among patients who had undergone removal of colorectal adenomas during the period from 1993 through 2007. …

Genetic testing of tumor is recommended for colorectal cancer patients

Universal Tumor Testing Universal genetic testing of the tumors for evidence of mismatch repair (MMR) deficiency of newly diagnosed colorectal cancer patients is recommended for several reasons: 1. Use of clinical criteria and prediction models to identify patients with Lynch syndrome have less than optimal sensitivity and specificity. 2. It has been shown to be cost effective for the diagnosis of Lynch syndrome. …

Colonoscopy withdrawal times linked to polyp detection rates

"There has been controversy over whether longer withdrawal times could lead to detection of increased numbers of polyps of various types," said Lynn F. Butterly, MD, director of Colorectal Cancer Screening at Dartmouth-Hitchcock Medical Center and NCCC, and associate professor of Medicine at the Geisel School of Medicine at Dartmouth. "Since the rate of discovery of polyps is a critical quality measure for colonoscopy, examining whether or not there is an association between withdrawal time and finding more polyps may contribute evidence leading to improved quality in screening through colonoscopy." During a colonoscopy, a lighted tube (colonoscope) is passed through the colon to find and remove polyps…

How bacteria found in mouth may cause colorectal cancer

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," says senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute. Colorectal cancer is the second leading cause of cancer-related death in the United States. …

Gene mutation may have effect on benefit of aspirin use for colorectal cancer

Colorectal cancer is a leading cause of cancer-related death worldwide. Randomized controlled trials have demonstrated that aspirin use reduces the risk of colorectal cancer, according to background information in the article. Experimental evidence has suggested that BRAF-mutant colonic cells might be less sensitive to the antitumor effects of aspirin than BRAF-wild-type (the typical form of a gene as it occurs in nature) neoplastic cells. …