Tag Archives: francisco

Cross-country collaboration leads to new leukemia model

And after almost a decade of bicoastal collaboration, Emmanuelle Passegué, now a professor in the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at the University of California, San Francisco, and Amy Wagers, a professor in Harvard’s Department of Stem Cell and Regenerative Biology, have the answer. They have found that cancer stem cells actively remodel the environment of the bone marrow, where blood cells are formed, so that it is hospitable only to diseased cells. This finding could influence the effectiveness of bone marrow transplants, currently the only cure for late-stage leukemia, but with a 25 percent success rate due to repopulation of residual cancer cells…

New medication treats drug-resistant prostate cancer in the laboratory

The results will be presented Monday at The Endocrine Society’s 95th Annual Meeting in San Francisco. "Our novel prostate cancer drug works by a unique mechanism of action," said study lead author Jeremy Jones, PhD, assistant professor of molecular pharmacology at City of Hope, Beckman Research Institute, in Duarte, CA. "Thus, it has the potential to treat cancers resistant to currently approved therapies." Prostate cancer is the second-leading cause of cancer death, after lung cancer, among men in the United States, according to the American Cancer Society. The disease affects about one out of every six men, and more than 29,000 will die of prostate cancer this year alone. …

Exposure to BPA in developing prostate increases risk of later cancer: Ubiquitous plasticizers may have long-term health effects

Prins presented her findings at the ENDO 2013 meeting in San Francisco June 17. "This is the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day environment, increases the risk for prostate cancer in human prostate tissue," said Prins, professor of physiology and director of the andrology laboratory in urology at the UIC College of Medicine. The increased risk can be traced to prostate stem and progenitor cells which become "sensitized" to estrogen early in development through exposure to BPA — which mimics estrogen in the body. …

Vitamin D supplementation may delay precocious puberty in girls

Among girls, puberty generally begins between the ages of 10 and 14. Boys undergo these changes later, usually between 12 to 16 years of age. Precocious puberty is diagnosed in girls when sexual development begins before the age of 8; in boys, it is diagnosed when these changes occur before age 9. Recently, medical research has linked vitamin D deficiency to a number of diseases, including cancer, obesity and autoimmune disease. …

Exposure to low doses of BPA linked to increased risk of prostate cancer in human stem cells

BPA is a synthetic estrogen that is used to add flexibility to many common products, including food cans and containers, compact discs, eyeglasses, and even baby bottles. It is universally prevalent, and tests indicate that almost everyone has measurable levels of the chemical in their bodies. The chemical has received a great deal of media attention in recent years because of its potential to increase the risk of disease…

Vegetable fats tied to less prostate cancer spread

After being diagnosed with prostate cancer, men who eat a diet high in vegetable fats, such as those in nuts and olive oil, may be less likely to have their disease spread, a new study suggests. Researchers found that replacing some carbohydrates with those healthy fats was also tied to a lower risk of dying from any cause during the study. But the opposite was true for saturated and trans fats often found in meat and processed foods. “A lot of doctors will simply say, ‘Cut out fat,'” after a prostate cancer diagnosis, said Dr. Stephen Freedland, a urologist at Duke University Medical Center in Durham, North Carolina. But this study challenges that advice, said Freedland, who wrote a commentary on the findings. “It actually says, if you eat more fat, albeit the right kind of fat,… you're less likely to die of not only prostate cancer, but really of any cause, which really flies in the face of this ‘low-fat, low-fat, low-fat' mantra that we've been told for decades now,” he said. Researchers tracked 4,577 men who were diagnosed with localized prostate cancer during a large study of health workers beginning in 1986. Those men filled out questionnaires every four years on how often they ate or drank about 130 different types of foods and beverages. Over the next eight to nine years, 315 men developed lethal prostate cancer - cancer that spread to other parts of the body or killed them - and 1,064 died from any cause. Men who reported getting the highest proportion of their daily calories from vegetable fat - more than 21 percent - after their diagnosis were about one-third less likely to die during the study than those who ate the least vegetable fat. And they had a borderline lower risk of developing lethal cancer. On the other hand, men who ate a similar amount of animal fat tended to be more likely to die during follow up, from prostate cancer or anything else, than those who skimped on animal meat. Erin Richman of the University of California, San Francisco, and her colleagues found that switching 10 percent of daily calories from carbohydrates to vegetable fat was linked to a 29 percent lower risk of lethal prostate cancer and a 26 percent lower chance of dying from any cause. But replacing 5 percent of those calories with saturated fat, or just 1 percent with trans fat, was tied to a 25 to 30 percent higher risk of death during the study period, according to findings published Monday in JAMA Internal Medicine. “The benefit was really when you were replacing refined carbohydrates with (things like) olive oil and nuts,” Richman said. She said vegetable fats contain antioxidants and may reduce inflammation in the body, thereby making it harder for cancer to spread. The American Cancer Society estimates about one in six U.S. men will be diagnosed with prostate cancer during his lifetime, and one in 36 will die of the disease. Because how animals are fed and how meats are cooked may both affect cancer risks associated with eating animal fats, Freedland said, “It becomes difficult to say, ‘Animals are bad; vegetables are good.' It's not that simple.” He recommends that men with prostate cancer cut out simple sugars and processed foods, as that is one of the easiest ways to get to a healthy weight. But not all fat should go. Richman agreed. “I think there's enough established benefit that you're not going to do any harm by adding nuts or olive oil,” she said.source : http://www.foxnews.com/health/2013/06/11/vegetable-fats-tied-to-less-prostate-cancer-spread/

Men with prostate cancer should eat healthy vegetable fats, study suggests

By substituting healthy vegetable fats — such as olive and canola oils, nuts, seeds and avocados — for animal fats and carbohydrates, men with the disease had a markedly lower risk of developing lethal prostate cancer and dying from other causes, according to the study. The research, involving nearly 4,600 men with non-metastatic prostate cancer, could help with the development of dietary guidelines for men with the disease. While prostate cancer affects millions of men around the world, little is known about the relationship between patients’ diets following their diagnosis and progression of the disease…

How to cheer yourself up

Look on the bright side. Keep your chin up. See the glass as half-full. Feel better yet? If these bumper-sticker mantras fail to do the trick, follow the surprising advice from experts who know all about keeping spirits high. Related: 25 Easy Instant Energy Boosters Do the Chicken Dance “Adults sometimes forget what kids intuitively understand: that moving your body helps release negative emotions. I’m a big believer in doing that myself.  “Once, I had a confrontation with one of my band members before a performance. We resolved the argument, but there were residual hard feelings—I still felt upset. And so I changed the set list to begin with a loud song of ours called “We Are the Dinosaurs.” That way, I was able to roar and stomp around on stage and transform my bad mood into something else.  “Try some variation of this yourself the next time you’re down. If you don’t release your emotions, sadness and helplessness will continue to pile on top of each other.” - Laurie Berkner is a best-selling children’s recording artist and a co-creator of “Sing It, Laurie!” an animated musical series for preschoolers on Sprout. She lives in New York City. Related: 10 Tips for Becoming a Morning Person Look Out the Window “When I’m having a trying moment, I walk over to my office window and gaze outside. Maybe I’ll spot a family of quail enjoying the suet cakes I’ve left them. Or a silly vehicle will drive by:  “One day I was ecstatic to see a bright pink kiddie-amusement-park ride breeze past on a huge flatbed trailer. We tend to view our burdens as more intimidating than they actually are. Taking a moment to stop and simply observe the world in all its beauty and strangeness is one of the best ways I know to get perspective.” - Elizabeth Fournier is the owner and operator of Cornerstone Funeral Services, in Boring, Oregon. Related: Are You Tired All the Time?