“It’s really all about natural selection and survival of the fittest,” says James DeGregori, PhD, investigator at the CU Cancer Center, professor of Biochemistry and Molecular Genetics at the CU School of Medicine, and the paper’s senior author. “When you’re young, healthy cells are optimized to the surrounding tissue — they’re the ‘fittest’,” DeGregori says. …
The research, which has shown promise in clinical samples, has been published in the scientific journal, Cell Death and Disease. The group of scientists coordinated by Dr Salvador Macip from the Mechanisms of Cancer and aging Lab and the Department of Biochemistry of the University of Leicester carried out the study to find new ways of identifying old cells in the body…
Furin is responsible for activating certain proteins and is involved in the processing and maturation of viral and bacterial preproteins. Indeed, the strength of Furin activity has already been recognised, and used previously by scientists to propose broad anti-viral, anti-bacterial, and anti-cancer treatments. This study used the binding site of human Furin in molecular dynamics (MD) simulation. Author of the study, Omotuyi Olaposi, a lecturer in Biochemistry at the Adekunle Ajasin University, Nigeria, explains that the experiment ‘may provide further insight to the design of novel drugs for Ebola virus disease treatment’…
For the first time, the group led by Robert Tamp�, in collaboration with colleagues at the University of California in San Francisco, succeeded in determining the structure of an asymmetrical ABC transporter complex with the aid of a high-resolution cryo-electron microscope. “Over a period of five years, we have successfully implemented a number of innovative, methodological developments. …
source : http://www.sciencedaily.com/releases/2014/02/140203191835.htm
The finding helps explain why a high-fiber diet reduces the risk of colon problems and indicates that when fiber is lacking, niacin, or vitamin B3, just may help keep the colon healthy as well, said Dr. Vadivel Ganapathy, Chairman of the Department of Biochemistry and Molecular Biology at the Medical College of Georgia at Georgia Regents University and a corresponding study author. The study found that mice lacking the receptor, Gpr109a, were prone to inflammation and cancer of the colon, said Dr. Nagendra Singh, MCG immunologist, member of the Cancer Immunology, Inflammation and Tolerance Program at the GRU Cancer Center, and a corresponding study author. …
Tumor cells escape a primary tumor by a process called invasion. …
Now, a team of researchers led by Philippe Frank, Ph.D., a cancer biologist in the Department of Biochemistry and Molecular Biology at Thomas Jefferson University, has shown that an HDL receptor found on breast cancer cells may be responsible for this effect, proposing a new molecular target that could help treat the disease. …