Category Archives: Cancer

Polish man gets face transplant just 3 weeks after injury

WARSAW, Poland – & A 33-year-old Polish man received a face transplant just three weeks after being disfigured in a workplace accident, in what his doctors said Wednesday is the fastest time frame to date for such an operation. It was Poland's first face transplant. Face transplants are extraordinarily complicated and relatively rare procedures that usually require extensive preparation of the recipient over a period of months or years. But medical officials said the Polish patient's condition was deteriorating so rapidly that a transplant was seen as the only way to save his life. The patient is now being watched for any potential infections. In a photo taken Tuesday, just six days after the surgery, the patient, identified only by his first name, Grzegorz, was shown giving a thumbs-up sign from his hospital bed. Another picture, based on computer tomography, showed the extensive damage to his skull. He was injured in an April 23 accident at his job at a stone mason's workshop near the southwestern city of Wroclaw when a machine used to cut stone tore off most of his face and crushed his upper jaw. He received intensive treatment at a hospital in Wroclaw that saved his life and eyesight. But an attempt to reattach his own face failed, leaving an area close to the brain exposed to infections, doctors said. The damage was too extensive for doctors to temporarily seal the exposed areas. So he was taken to the Cancer Center and Institute of Oncology in Gliwice, the only place in Poland licensed to perform face transplants. The center has experience in facial reconstruction for patients disfigured by cancer and its experts have practiced face transplants on cadavers. Doctors at the center said the 27-hour face and bone transplant was performed May 15 soon after a matching donor was found. The surgery reconstructed the area around the eyes, the nose, jaws and palate and other parts of the man's face. Pictures show stitches running from above the patient's right eye, under the left eye and around the face to the neck. The donor, a 34-year-old man, was chosen from a national registry of potential donors after his age, gender, blood group and body features were determined to be a good match for the injured man. The head of the team of surgeons and other specialists, Dr. Adam Maciejewski, said it was the first time a face transplant was carried out so soon after the damage. Face transplants are usually a last resort after conventional reconstructive and plastic surgeries have been tried. “In such an extensive injury, where the structures close to the skull base and in contact with the brain area are exposed, any infection would be dangerous, not to mention the impossibility to function normally, including problems with breathing, with eating,” Maciejewski said. “All that led us in one direction.” “We assume the surgery will allow the patient to return to normal life. He will be able to breathe, to eat, to see.” Maciejewski said that over time, the face will mold to the man's facial bone structure and he will not look like the donor. The patient is now breathing on his own and responds to questions by nodding his head or squeezing the hands of doctors. But his condition is serious and it will be months before the procedure can be declared a full success, said Dr. Krzysztof Olejnik, head of the team of anesthesiologists. Another member of the transplant team, surgeon Dr. Maciej Grajek, told The Associated Press that the patient was receiving drugs to ward off any potential viral, bacterial or skin infections, but the face is alive and is healing. Though he is in sterile isolation, the patient has started the rehabilitation process. He will stay on special drugs for the rest of his life to prevent rejection of his new face. More than two dozen transplants of the face or parts of the face have been performed around the world. The first one was a partial face transplant in a woman maimed by her dog in France in 2005. Dr. Bohdan Pomahac, who in 2011 led a team in the United States that performed a full face and double-hand transplant on a woman mauled by a chimpanzee, said in an email he believes that in the future surgeons will decide more swiftly on a transplant, just as the Polish team did. “This is the way we likely will practice in the future,” said Pomahac, a reconstructive surgeon at Harvard-affiliated Brigham and Women's Hospital in Boston. However, he cautioned that patients should be given more time to be fully involved in a decision that will have a life-long impact on them. “I still think that a traumatized patient, even with all the psychological support, probably has a hard time making the right decision within hours/days after life-changing trauma,” Pomahac said. Dr. Zbigniew Wlodarczyk, who has performed limb transplants in Poland but was not involved in the face transplant, told the AP the surgery was groundbreaking because it was carried out on a fresh injury and on tissues that have not healed, but that leaving such an extensive wound open would have led to infection and the patient's death. “Such rare but spectacular procedures show the possibilities of medicine today and advance it,” he said.  ”This places Poland in the elite group of countries performing such transplants.  source : http://www.foxnews.com/health/2013/05/23/polish-man-gets-face-transplant-just-3-weeks-after-injury/

Feet contain most fungi on body, new research shows

A new map of the fungal species lurking on human skin reveals the most diverse communities can be found on — you guessed it — the bottom of the feet. Genetic sequencing found the fungal genus Malassezia dominated on most of the core body regions and arms. The heel, toenail and toe web (skin between the toes), by contrast, supported highly varied fungal communities. Imbalances in these populations may lead to athlete's foot and other fungal diseases, the researchers say. The skin serves as a barrier to pathogenic microorganisms, but is also home to a rich array of harmless microbes. Until now, most efforts to study the skin's microorganisms have focused on bacterial species, but fungi (which are a distinct biological group) form a significant part of these skin communities. Feet love fungi In the study, scientists took skin scrapings from 10 healthy adults at 14 different sites on the body. They sequenced the DNA from the swabs. In addition, the researchers isolated more than 130 fungal strains from the genera Malassezia, Penicillium and Aspergillus, and grew them in the lab.   The genus Malassezia, which may cause dandruff, was the most abundant type of fungus at all 11 core-body and arm sites, results showed. These areas included the inner elbow, palm, space between the eyebrows, back of the head, nostril and forearm, among other spots. Core-body sites, such as the chest and abdomen, had the fewest types of fungi, ranging from two to 10 genera. The three foot sites — heel, toenail and toe web — contained much greater fungal diversity, with populations of Malassezia¸ Aspergillus, Cryptococcus, Rhodotorula and Epicoccum, among others. Overall, the heel had the most diverse fungal makeup, with about 80 fungal genera. One study participant had an especially diverse array of fungi. This person had taken a course of oral antifungal medication for a toenail infection seven months prior to the study. The unusual fungal diversity suggests that either an imbalance in the fungal community was causing the stubborn toenail infections, or that changes in the microbe composition due to the medication continued even seven months after stopping treatment, the researchers say. The results demonstrate that human skin is capable of harboring a highly varied fungal population. When fungi go awry The researchers also sequenced bacteria on the skin. The results confirmed previous findings for skin bacterial makeup in healthy people. In contrast to fungal populations, the most diverse bacterial populations were found on the arms. The person with abnormal fungal diversity appeared to have a normal distribution of bacteria. The study of the skin's native fungi has important implications for infection and disease. About 20 percent of the study participants showed signs of possible foot fungal infections, and previous studies have shown up to 60 percent of healthy people may harbor such infections. Fungal infections affect 29 million North Americans. Several factors influence the prevalence of fungal infections, including population and climate. Antifungal medications can have dangerous side effects, and new treatments that target fungal imbalances are needed, the researchers say. The findings were reported online May 22 in the journal Nature.  source : http://www.foxnews.com/health/2013/05/22/feet-contain-most-fungus/

Software company to recruit people with autism as programmers

German software company SAP is looking to recruit people with autism as programmers and product testers, drawing on skills that can include a close attention to detail and an ability to solve complex problems. SAP has asked start-up Danish recruitment company Specialisterne to help it find, train and manage employees diagnosed with the disability. “They bring a special set of skills to the table, which fits with SAP,” said a spokesman for the company, which has already hired people with autism in India and Ireland. Specialisterne Chief Executive Steen Thygesen said the partnership was his first with a multinational company to help with its worldwide recruitment. The Danish company says it has already helped several hundred autistic people to find a job. Sufferers often find it harder to communicate and some have lifelong learning disabilities. Those with a form of autism known as Asperger syndrome can sometimes have above-average intelligence. As children, they may prefer mathematics and other subjects rooted in logic and systems, according to Britain's National Autistic Society. “People with autism have some unique abilities to really focus on their task and stay focused for long periods of time. They are also good at spotting discrepancies in data,” said Thygesen, a former manager with Microsoft and Nokia whose 14-year-old son has Asperger syndrome. According to the U.S. Centers for Disease Control and Prevention, 1 in every 88 children in the United States and almost 1 in 54 boys are diagnosed with autism. The SAP spokesman said the company aimed to reflect the proportion of people diagnosed as autistic in society within its 65,000-strong workforce - or about 1 percent. A Berlin-based company, Auticon, already exclusively employs autistic people as software testers. It has a team analyzing data for Vodafone Germany, an Auticon spokesman said.source : http://www.foxnews.com/health/2013/05/22/software-company-to-recruit-people-with-autism-as-programmers/

Could eating less save your brain? Study shows reducing calories delays nerve cell loss

Calorie restriction may not always be fun, but cutting back has benefits beyond even weight loss. Studies have shown that eating less can help slow aging, prolong life and even decrease the effects of diseases like Alzheimer’s in a variety of organisms. Based on this knowledge, a group of researchers from the Massachusetts Institute of Technology (MIT) decided to dig further and ask: Could calorie restriction also delay nerve cell loss in the brain – and the changes in learning and memory that go along with it? “We reasoned – and other folks reasoned – that because cognitive decline and neurodegeneration are characteristics of the aging process, that calorie restriction might also work in the brain to slow neurodegeneration,” lead study author, Dr. Johannes Gräff from the Picower Institute for Learning and Memory at MIT, and Howard Hughes Medical Institute, told FoxNews.com. Gräff and his colleagues tested their theory using a group of mice engineered to experience rapid neurodegeneration. Researchers decreased half of the mice’s calorie intake by 30 percent and kept the remaining mice on a normal diet. After three months, researchers tested the learning and memory skills in each group of mice, expecting to see a decline in both cognitive areas. However, while the mice eating normally showed evidence of significant learning and memory deficits related to nerve cell loss, the calorie-restricted mice showed no defecits in their learning or memory skills. “That was one of the first experiments we did, and that was quite promising and cool that it worked,” Gräff said. In the next phase of the study, researchers took a more in-depth look at the brains of both groups of mice. “What we further did was to look through the brains to check the extent or amount of neurodegeneration, and what we found was that neurodegeneration had been slowed down by calorie restriction,” Gräff said. Researchers were curious if reduced neurodegeneration could still be achieved by utilizing proteins activated during calorie restriction – without actually restricting calories. Eventually, they targeted an enzyme called Sirtuin 1 (SIRT1). “This protein is one candidate that has been known to be more abundantly expressed as a result of calorie restriction in our tissues,” Gräff said. The scientists then gave a separate group of mice, also engineered to experience rapid neurodegeneration, a pharmacological dose of SIRT1, without restricting their calorie intake. These mice experienced the same effects as the calorie-restricted mice, showing slower rates of nerve cell loss and no learning or memory deficits after a three-month period. Graff noted that more research needed to be done in this area, and he hopes to further explore the relationship between calorie restriction, SIRT1 and neurodegeneration. “We have the choice – (to look into how) to reduce calorie intake in order to slow onset of neurodegeneration, or we look to this pharmacological activator (to do the same thing),” Gräff said. “Do you want to engage more into reducing caloric intake or revert to pharmacological means for the same effect?” This study is published in the May 22nd issue of The Journal of Neuroscience.source : http://www.foxnews.com/health/2013/05/22/could-eating-less-save-your-brain-study-shows-reducing-calorie-intake-delays/

Study details genes that control whether tumors adapt or die when faced with p53 activating drugs

"The gene p53 is one of the most commonly mutated cancer genes. Tumors turn it off and then they can avoid controls that should kill them. Fine: we have drugs that can reactivate p53. But the bad news is when we go into the clinic with these drugs, only maybe one in ten tumors actually dies. …

Women escorted from mall for wearing “F— CANCER” hats

Two sisters were escorted from a mall in King of Prussia, Pa., on Sunday because they were wearing hats reading “F--- CANCER” with the “C” in the expletive replaced by a pink breast cancer awareness ribbon, the Philadelphia Daily News reported. Zakia Clark, 29, and Tasha Clark, 27, said that they were wearing the shirts to honor their mother, Jackie Underwood, who had passed away on May 14 at the age of 51 after a battle with breast cancer. The women, both from Philadelphia, were at the King of Prussia Mall with a group of friends and relatives, shopping for a dress for Zakia’s daughter to wear to their mom’s funeral. After two-and-a-half hours of shopping, the women were approached by a security guard in the mall’s food court. Zakia told the Philadelphia Daily News that the guard approached them without a greeting and said, “‘Take your hats off.’” Zakia removed her hat, but Tasha – a former mall employee – asked to see something in writing. “He said, 'Since you don't want to take your hat off, you can leave my mall,'” Zakia told the Philadelphia Daily News. “He stood there while we ate and threatened to call the cops.” The women stated that seven more guards then approached them and escorted them to the mall office. “I was very embarrassed,” Zakia told the Philadelphia Daily News. “My daughter was so scared she was crying.” At the mall office, the women were met by a police officer who had been called by mall security. “The officer said, 'I find it offensive that you even have that hat that says 'F--- CANCER,' ” Zakia recalled. “He said, 'It's their mall, they want you out, you have to get out.'” The women were escorted out of the mall, and two security cars waited by the sisters’ car until they left. After the Philadelphia Daily News looked into the incident, Les Morris, a spokesman for Simon Property Group in Indianapolis, IN., which owns King of Prussia Mall, called Zakia to apologize. “Certainly this could have been handled in a much more empathic and sensitive manner,” Morris told the People Paper. “We're very sorry about her loss and wanted to apologize for the way her party was treated.” “I do think this is an entirely different situation than a 16-year-old kid with a swear word on his T-shirt cruising the mall,” Morris said. Click for more from the Philadelphia Daily News.source : http://www.foxnews.com/health/2013/05/22/women-escorted-from-mall-for-wearing-f-cancer-hats/