Category Archives: Cancer Knowledge

Scientists map risk of premature menopause after cancer treatment

The findings, set out in the Journal of the National Cancer Institute, are based on the experience of more than 2,000 young women in England and Wales treated for the cancer over a period of more than 40 years. Previous research has suggested that women with Hodgkin lymphoma who receive certain types of chemotherapy or radiotherapy are at increased risk of going through the menopause early — but there was insufficient information to provide patients with detailed advice. But the new study, led by scientists at The Institute of Cancer Research, London, provides precise estimates of risk for women depending on which treatment types and doses they received and at what age — allowing doctors to give them detailed advice about their risks of future infertility…

Online screening for rare lung cancer mutation opens door to new kind of clinical trial

The University of Colorado Cancer Center is now taking a novel approach to this problem, reaching out via the internet to expand the pool of patients potentially eligible for just such a biomarker-preselected clinical trial. …

High concordance between EGFR mutations from circulating-free tumor DNA and tumor tissue in non-small cell lung cancer

EGFR tyrosine kinase inhibitor (TKI) therapy is approved for EGFR activating mutation positive patients with advanced NSCLC, but the standard for determining mutation status is with DNA derived directly from tumor tissue, which can be limited or not available. …

Astonishing regeneration potential of the pancreas

Approximately 40,000 persons in Switzerland suffer from type-1 diabetes. …

Blueprint for next generation of chronic myeloid leukemia treatment

Drugs already in use, called tyrosine kinase inhibitors (TKIs), target BCR-ABL and are effective at controlling the disease. They do not cure CML but control it in a way that allows patients to get back to normal life and a normal expected lifespan…

Women with severe, chronic health issues are screened for breast cancer less often — ScienceDaily

They are also screened less often than women with moderate disabilities or women with only one chronic condition, according to Dr. Sara Guilcher, an affiliate scientist with the Li Ka Shing Knowledge Institute of St. Michael’s Hospital…

Study identifies protein that helps prevent active tuberculosis in infected patients

The discovery could help doctors identify people who are at the greatest risk for the highly contagious and potentially fatal lung disease, and it could point the way toward new treatment strategies for TB. The study, conducted in partnership with researchers from Harvard University School of Public Health and the University of Michigan School of Medicine, was published in the Aug. 20 online edition of the journal Science Translational Medicine…

Biomarker in aggressive breast cancer identified — ScienceDaily

Using breast cancer patient data taken from The Cancer Genome Atlas, molecular biologists Curt M. Horvath and Robert W. Tell used powerful computational and bioinformatics techniques to detect patterns of gene expression in two cancer subtypes. …

Biomarker in aggressive breast cancer identified

Using breast cancer patient data taken from The Cancer Genome Atlas, molecular biologists Curt M. …

Leukemia drug shows promise for skin, breast and other cancers — ScienceDaily

Dasatinib fights leukemia by checking the uncontrolled growth of cancer cells. But when used against other cancer cells, researchers found, the drug employs a different strategy: It causes the cells to clump together, thus preventing them from migrating. Without the ability to migrate, cancer cells cannot metastasize (spread to other parts of the body)…