Category Archives: Cancer Knowledge

Skirt size increase linked to 33 percent greater postmenopausal breast cancer risk

The researchers base their findings on almost 93,000 women taking part in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) in England. The women were all aged over 50, had gone through the menopause, and had no known breast cancer when they entered the study between 2005 and 2010. At enrolment they provided detailed information on height and weight (BMI); reproductive health; fertility; family history of breast and ovarian cancer; and use of hormonal contraceptives and HRT, all of which influence breast cancer risk. They were also asked about their current skirt size, and what this had been in their 20s. …

How the ends of chromosomes are maintained for cancer cell immortality

Telomeres stay intact in most cancer cell types by means of a specialized enzyme called telomerase that adds the repetitive telomere DNA sequences to the ends of chromosomes. Cancer cells can also use a second method involving a DNA-repair-based mechanism, called alternative lengthening of telomeres, or ALT for short. In general, cancer cells take over either type of telomere maintenance machinery to become immortal. …

Researchers engineer ‘Cas9’ animal models to study disease, inform drug discovery

In recent years, genetic studies have found thousands of links between genes and various diseases. But in order to prove that a specific gene is playing a role in the development of the disease, researchers need a way to perturb it — that is, turn the gene off, turn it on, or otherwise alter it — and study the effects. The CRISPR-Cas9 genome-editing system is one of the most convenient methods available for making these alterations in the genome. While the tool is already being used to test the effects of mutations in vitro — in cultured cell lines, for instance — it is now possible to use this tool to study gene functions using intact biological systems…

Most breast cancer patients who had healthy breast removed at peace with decision — ScienceDaily

The study made a surprising finding: While most women were satisfied with their decision whether they followed it with breast reconstruction or not, patients who decided against reconstructive surgery were likelier to say they would choose to have both breasts removed again. …

Immune system is key ally in cyberwar against cancer

“Recent research has found that cancer is already adept at using cyberwarfare against the immune system, and we studied the interplay between cancer and the immune system to see how we might turn the tables on cancer,” said Rice University’s Eshel Ben-Jacob, co-author of a new study this week in the Early Edition of the Proceedings of the National Academy of Sciences. Ben-Jacob and colleagues at Rice’s Center for Theoretical Biological Physics (CTBP) and the University of Texas MD Anderson Cancer Center, developed a computer program that modeled a specific channel of cell-to-cell communication involving exosomes. Exosomes are tiny packets of proteins, messenger RNA and other information-coding segments that both cancer and immune cells make and use to send information to other cells…

New ‘designer proteins’ in fight against Alzheimer’s, cancer

The team has developed an innovative process allowing them to generate a particular type of synthetic amino acid — and a particular type of designer protein — that has not been done before. The advance is announced by the Jamieson Research Group in the Department of Chemistry at the University of Leicester…