Category Archives: Cancer Knowledge

Gene ‘switches’ could predict when breast cancers will spread to the brain — ScienceDaily

The researchers, based at the University of Wolverhampton, studied 24 breast cancers that had spread to the brain, along with samples from the original breast tumour, and found a handful of genes with faulty switches. Crucially, two of the genetic switches became faulty early on in the development of breast cancer, suggesting they may be an early warning signal for tumours that will spread to the brain. The scientists are now working to develop a blood test that might be able to detect these signals at an early stage, before the disease has spread. …

Immune booster combined with checkpoint blocker improves survival in metastatic melanoma

Patients in the clinical trial who got the combined therapies also had fewer serious adverse side effects than those who received only ipilimumab, the researchers report in the Journal of the American Medical Association. The group treated with both ipilimumab and the immune stimulant, called sargramostim, had a one-year survival rate of 68.9 percent vs. 52.9 percent in the ipilimumab-only group. In both groups, however, the median progression-free survival (the length of time before the cancer began to grow) was similar – 3.1 months…

Trial results reveal first targeted treatment to boost survival for esophageal cancer

Up to one in six patients with esophageal cancer were found to have EGFR duplication in their tumor cells and taking the drug gefitinib, which targets this fault, boosted their survival by up to six months, and sometimes beyond. This is the first treatment for advanced esophageal cancer shown to improve survival in patients whose initial course of chemotherapy treatment has failed. It is also the first time a targeted treatment of any kind has proved effective in this disease, although chemotherapy and some targeted drugs have shown benefit in the second line treatment of other cancers of the digestive system including stomach cancer…

Scientists uncover potential drug to tackle ‘undruggable’ fault in third of cancers

A team of scientists at the Max Planck Institute of Molecular Physiology in Germany has uncovered a new strategy and new potential drug to target an important signalling protein in cells called Ras, which is faulty in a third of cancers. When the Ras protein travels from the centre of a cell to the cell membrane, it becomes ‘switched on’ and sends signals which tell cells to grow and divide. …

Breast cancer recurrence: Study provides insight

Around 5,000 cases of DCIS, a condition where cancerous cells are contained within the milk ducts of the breast, are diagnosed each year in the UK, with two thirds diagnosed through breast screening. If left untreated, up to half of DCIS cases could progress into invasive breast cancer, but it is not possible to say which ones, so all women are offered treatment. This usually involves breast-conserving surgery (lumpectomy) and, to reduce the risk of the cancer returning, radiotherapy to kill any remaining cancer cells. However, even with treatment up to one in five patients will see their DCIS come back, either as DCIS or as invasive breast cancer. …

Radiation a risk factor for brain tumors in young people, study finds

Researchers analyzed records of 35 patients who were diagnosed with meningiomas before age 30. Five had been exposed to ionizing radiation earlier in their lives. They include two patients who received radiation for leukemia at ages 5 and 6; one who received radiation at age 3 for a brain tumor known as a medulloblastoma; and one who received radiation for an earlier skull base tumor that appeared to be a meningioma. …

Clear new evidence for mind-body connection demonstrated in study — ScienceDaily

A group working out of Alberta Health Services’ Tom Baker Cancer Centre and the University of Calgary Department of Oncology has demonstrated that telomeres — protein complexes at the end of chromosomes — maintain their length in breast cancer survivors who practise meditation or are involved in support groups, while they shorten in a comparison group without any intervention. Although the disease-regulating properties of telomeres aren’t fully understood, shortened telomeres are associated with several disease states, as well as cell aging, while longer telomeres are thought to be protective against disease. “We already know that psychosocial interventions like mindfulness meditation will help you feel better mentally, but now for the first time we have evidence that they can also influence key aspects of your biology,” says Dr. Linda E. …

Lactose intolerants at lower risk of certain cancers: Study — ScienceDaily

“We found that people with lactose intolerance, who typically consume low amounts of milk and other dairy products, have a reduced risk of lung, breast and ovarian cancers,” says Jianguang Ji, Associate Professor at Lund University and researcher at the Center for Primary Care Research in Malm�. “The risk of cancer was not reduced in relatives of people with lactose intolerance, which indicates that protection against these cancers is related to diet. However, it would be wrong to conclude that milk is a risk factor for these cancers,” emphasises Jianguang Ji. …

Lung cancer diagnosed before it is detected by imaging

The team of researchers led by Paul Hofman used a blood test developed during French research, which isolates all types of tumour cells from the bloodstream, without any loss, leaving them intact. The team studied a group of 245 people without cancer, including 168 patients at risk of later developing lung cancer because they had Chronic Obstructive Pulmonary Disease (COPD). Participants systematically underwent the blood test and standard diagnostic imaging tests…