Anti-Cancer Therapy

Potent mechanism helps viruses shut down body’s defense system against infection

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Published in the August issue of the journal Cell Host and Microbe, the findings describe a novel mechanism that this group of so-called "enveloped viruses" uses to disarm the host’s innate immune response. The mechanism the scientists uncovered is based on these viruses activating a class of molecules, known as TAM receptors, which are located on the outside of certain immune cells.

In the immune system, TAM receptors are used by cells, such as macrophages and dendritic cells, to clean up dead cells, and they are also central inhibitors of the body’s innate immune response to bacteria, viruses and other pathogens.

The Salk scientists found that a substance called phosphatidylserine (PtdSer), which is found on the surface of enveloped viruses (viruses with an outer wrapping of a lipid membrane), binds to extracellular proteins and activates TAM receptors on immune cells. In dendritic cells, a type of immune cell that interacts with T and B cells to initiate the adaptive immune response, TAM receptor activation turns off a set of genes called interferons that play a key role in antiviral defense.

"Our findings suggest a unique way in which TAM receptors contribute to the establishment of viral infection by disabling the interferon response," says co-lead study author John A.T. Young, a professor in Salk’s Nomis Foundation Laboratories for Immunobiology and Microbial Pathogenesis. "As a consequence, the interferon-stimulated defense genes are not turned on, rendering the target cell more permissive for virus infection."

This is a previously unknown mechanism for enveloped viruses, which are very common, to inhibit the body’s normal antiviral response. Since PtdSer exposure seems to be a general feature of enveloped viruses, the researchers say many different viruses may use the mechanism to counteract the cellular antiviral response in cells with TAM receptors.

Understanding this mechanism allows researchers to work on developing broad-spectrum antiviral drugs that prevent viruses from shutting down the interferon response in cells by blocking TAM receptor activation. In their study, the Salk scientists tested a small-molecule drug called BMS-777607, initially developed for anti-cancer therapy, that does just that.

"With this small molecule, viruses can’t activate TAM receptors, so they can’t shut down the interferon response," says co-lead author Greg Lemke, a professor in Salk’s Molecular Neurobiology Laboratory and the Françoise Gilot-Salk Chair, in whose laboratory TAM receptors were discovered.

With other scientists around the country, the Salk researchers are testing a variety of small molecule drugs in series of different viruses, including West Nile, Dengue, influenza, Ebola, Marburg, and hepatitis B. These drugs work, in large part, by blocking the virus’ ability to activate TAM receptors, thereby leaving the interferon-mediated antiviral response intact.

"This is a completely novel approach," says Young, who holds the Nomis Foundation Chair at Salk. "It is a way of exploiting a normal piece of the cellular machinery in the immune system to block virus infections." And, if it works, it may prove to be an effective treatment to clear enveloped viruses during the acute phase of infection and perhaps also in chronic virus infections.

Other researchers on the study were co-first authors Suchita Bhattacharyya and Anna Zagόrska, as well as Erin D. Lew and John Naughton, from the Salk Institute; Bimmi Shrestha and Michael S. Diamond of Washington University; and Carla V. Rothlin of Yale University.

The study was supported by the National Institutes of Health, the Nomis and Auen Foundations, the James B. Pendleton Charitable Trust, a Salk Institute innovation grant, the Human Frontiers Science Program, and the Leukemia and Lymphoma Society.

source : http://www.sciencedaily.com/releases/2013/08/130814191352.htm

Molecule drives aggressive breast cancer

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The scientists found that excess activity of this gene — EYA1 — also enhances development of breast cancer stem cells that promote resistance to cancer therapy, recurrence, and poor survival.

Because EYA1 is an enzyme, the scientists are now working to identify a natural compound that could shut down EYA1 activity, says Richard Pestell, M.D., Ph.D., Director of Kimmel Cancer Center.

"It was known that EYA1 is over-expressed in some breast cancers, but no one knew what that meant," he says. "Our studies have shown the enzyme drives luminal B breast tumor growth in animals and the enzyme activity is required for tumor growth."

In a mouse model of aggressive breast cancer, the research team targeted a single amino acid on the EYA1 phosphatase activity. They found that inactivating the phosphatase activity of EYA1 stopped aggressive human tumors from growing.

"We are excited about the potential of drug treatment, because it is much easier to develop a drug that targets a phosphatase enzyme like EYA1, than it is to target a gene directly," he says.

Tracing how EYA1 leads to poor outcomes

The study, which was published in the May 1 issue of Cancer Research, examined 2,154 breast cancer samples for the presence of EYA1. The researchers then linked those findings to patient outcomes. They found a direct relationship between increased level of EYA1 and cyclin D1 to poor survival.

They then chose one form of breast cancer — luminal B — and traced the bimolecular pathway of how EYA1 with cyclin D1 increases cancer aggressiveness. Luminal B breast cancer, one of five different breast cancer subtypes, is a hormone receptor-positive form that accounts for about 20 percent of human breast cancer. It is more aggressive than luminal A tumors, a hormone receptor-positive cancer that is the most common form of breast cancer.

Their work delineated a string of genes and proteins that are affected by EYA1, and they also discovered that EYA1 pushes an increase in formation of mammospheres, which are a measure of breast cancer stem cells.

"Within every breast cancer are breast cancer stem cells, which give rise to anti-cancer therapy resistance, recurrence and metastases," Dr. Pestell says. "We demonstrated in laboratory experiments that EYA1 expression increase the number of mammospheres and other markers of breast cancer stem cells."

"As the EYA1 phosphatase activity drove breast cancer stem cell expansion, this activity may contribute to worse survival," he says.

This study was supported in part by the NIH grants RO1CA132115, R01CA70896, R01CA75503, R01CA86072 and P30CA56036 (RGP), a grant from the Breast Cancer Research Foundation (RGP), a grant for Dr. Ralph and Marian C. Falk Medical Research Trust (RGP), Margaret Q. Landenberger Research Foundation, the Department of Defense Concept Award W81XWH-11-1-0303.

Study co-authors are, from Kimmel Cancer Center: first author Kongming Wu, Zhaoming Li, Shaoxin Cai, Lifeng Tian, Ke Chen, Jing Wang and Adam Ertel; Junbo Hu, from Huazhong University of Science and Technology, China; and Ye Sun, and Xue Li from Boston Children’s Hospital.

source : http://www.sciencedaily.com/releases/2013/06/130627190327.htm

New understanding of why anti-cancer therapy stops working at a specific stage

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The problematic therapy investigated involves suppression of the protein mTOR (mammalian target Of Rapamycin). MTOR plays an important role in regulating how cells process molecular signals from their environment, and it is observed as strongly activated in many solid cancers.

Drug-induced suppression of mTOR has until now shown success in causing the death of cancer cells in the outer layers of cancerous tumors, but has been disappointing in clinical trials in dealing with the core of those tumors.

Reduced oxygen supply — hypoxia — is a near-universal feature of solid tumors that can alter how tumors respond to therapies. It was known that the behavior of mTOR signaling is influenced and altered by the condition of hypoxia, but the mechanism to explain this was unknown.

A research team, which included Prof. Emeritus Raphael D. Levine of the Institute of Chemistry at the Hebrew University of Jerusalem and researchers from the California Institute of Technology and the David Geffen School of Medicine at UCLA, investigated whether the influence of hypoxia on mTOR signaling in model brain cancer systems could explain the poor performance of mTOR drugs. Their work appeared in a recent article in the Proceedings of the National Academy of Sciences (PNAS) in the US.

For their investigation, they employed a new microchip technology that allowed them to measure the mTOR protein signaling network in individual cancer cells, and they interpreted the results using a new set of theoretical tools derived from the physical sciences. The combined approach permitted the simplification of an otherwise complex biological system.

They found that at a particular level of oxygen starvation (hypoxia) that is common in solid tumors, the mTOR signaling network switches between two sets of properties. At the switching point, the theoretical models predicted that mTOR would be intrinsically unresponsive to drugging.

Furthermore, the combined experiment and theory results indicated that the switch could be interpreted as a type of phase transition, which has not been previously observed in biological systems.

This phase transition is the point of the switch between the two signaling networks and happens very abruptly. The change in signaling means that the body of cells studied no longer responds in the way it did before. In the case of the tumor, the "drugging" of the mTOR ceases, meaning that the tumor is no longer inhibited.

These results have several implications. First, they may explain the poor clinical performance of mTOR inhibitors. Second, they indicate that certain complex biological behaviors, which often confound scientists who are seeking to find effective therapies for human diseases, may be understood by the effective application of experimental and theoretical tools derived from the physical sciences.

source : http://www.sciencedaily.com/releases/2013/06/130624093522.htm

New delivery for cancer drugs

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That was back in the 1990s. Today, TNF-alpha is a prime example of how to safely and effectively deliver toxic substances to cancer cells through the use of nanotechnology.

McNeil’s lab, part of the federally funded research and development center operated by SAIC-Frederick for the National Cancer Institute, worked with a drug company to reformulate TNF-alpha by coupling it with gold nanoparticles. Using the nanotechnology-enhanced protein, it appears possible to safely inject up to three times the amount that had been lethal with previous versions. The modified drug has been through a Phase 1 clinical trial and is entering Phase 2.

In McNeil’s lab, and for other scientists using nanotechnology for drug delivery, stories like this one are increasingly common. Researchers are looking to accelerate the development of potential nanotechnology drugs for cancer by exploring ways to reduce side effects and make treatments hit their targets more effectively. This can mean using nanotechnology to reformulate drugs that may have failed in previous clinical trials. In some cases, by attaching a nanoparticle to an existing drug, researchers may not only be able to lower its toxicity, but they may also see significant life expectancy gains for patients.

Many cancer drugs are approved based on how long they delay the progression of disease. Some drugs on the market "only improve life expectancy by maybe five weeks," says McNeil. He sees nanomedicine as a potential game-changer for cancer drugs in the future.

McNeil, both a chemist and biologist, has spent the majority of his career working in nanotechnology, but when he was asked to apply his expertise to find better drugs for cancer, he was skeptical. "My professional career was mostly military," says the former Army officer. "I was using nanotech for military applications at SAIC, using quantum dots to see if you scatter things, where they land. I got a call out of the blue in December of 2003 and the message was, ‘We want to use nanotech for cancer applications.’ I thought, ‘What are they thinking? You are going to put a cadmium quantum dot in a human? There is no way!’ I discounted it at first and I actually ignored the emails, hoping it would go away."

But it did not go away. In fact, much has changed in the last 10 years. Now, nanopharmaceuticals are beginning to demonstrate their capacity to place the drugs directly in the tumor, where they will do the most good, rather than let them roam freely in the body. A drug is attached to a nanoparticle, which is often a tiny little sphere. To put it in perspective, a nanometer is one billionth of a meter; the width of a single strand of hair is about 10,000 nanometers. The nanoparticle is small enough to flow through blood vessels and into a tumor, where the particle dissociates, and the drug is released. In the end, the goal of nanomedicine is that the only part of the body affected by the drug is the tumor, the area of need.

McNeil’s Nanotechnology Characterization Lab was founded in 2004 in collaboration with the Food and Drug Administration and the National Institute of Standards and Technology. There is one thing the lab does not do: develop nanotechnology drugs. Instead, researchers there — ranging in expertise from cancer biology and toxicology to chemistry, immunology, and physics — help investigators from around the world create the best drugs possible. "We help investigators get from proof of concept, where they are generating a few tens of milligrams of material and get into clinical trials, where they are going to need kilograms of materials," say McNeil. "That translational research, as we call it, is absolutely germane to getting into clinical trials."

The majority of scientists who apply for assistance from the NCL are seeking FDA approval for their nanotech drugs but they don’t have the resources to optimize their formula. The NCL can help. "We help them understand what is involved with their particle because they don’t have the tools that we have to be able to characterize," says McNeil. "They may have a nice picture or cartoon of it but until they see our electron micrographs, they don’t know what it looks like."

The Nanotechnology Characterization Lab serves two purposes. After a molecule has been through the NCL’s assay cascade which consists of a set of tests that evaluate the preclinical toxicology, pharmacology, and efficacy of nanoparticles, the NCL is able to offer an evaluation. "The investigator is going to need $40 million dollars to get into Phase 2 trials. Investigators need to justify the investment. We help them generate data they need to further their work and then we serve as a third-party evaluation." That is crucial, McNeil says, for an investigator seeking funding. "A venture capital company can come to us and say, ‘Well, what do you really think of this? Let’s see your data, and explain it and defend it.’ We, obviously, cannot endorse it but we can discuss the data in the context of what they are trying to do. That really holds a lot of weight."

Consider the example of Abraxane (paclitaxel), which was approved for use by the FDA in 2005. Abraxane, a variably toxic but widely prescribed cancer drug, has been enhanced by attaching it to a nanoparticle, thereby creating a new, targeted treatment. "Because of the size and the binding to a different receptor, that drug now has decreased toxicity compared to the former drug. For the nanoparticle-Abraxane conjugate toxicity is very marginal, at least for immunotoxicity and hypersensitivity," says McNeil.

Since 2005, the Nanotechnology Characterization Lab has characterized nearly 300 different particles. Six of them are in clinical trials. "Depending upon what community you are from, either that is a terrific ratio or that is a poor ratio," explains McNeil. "We view it as a super terrific ratio. A pharmaceutical company can make hundreds of thousands of different drugs and only about one out of 100,000 gets into clinical trials."

source : http://www.sciencedaily.com/releases/2013/05/130507154945.htm

Prostate cancer, bladder cancer, kidney cancer therapy regimen Trinity Green

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10 10 + = 1800 / 1, An Kangxin capsules 10 boxes + 10 Xiaoaiping piece gift box + = 1,800 yuan / month
        8 10 + = 1200 / 2, West Pill Box + Xiaoaiping 8 pieces 10 boxes + gifts = 1200 yuan / month
        15 3 Capsule 15 boxes of compound cantharidin 10 + = 800 / + 10 Xiaoaiping piece gift box + = 800 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of     Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days.   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.    1 30 3, 1 bottle of 30-day gifts       6 20 4, Se Po capsule 6 in 20 days.
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Note: For your complete and early to see the effect of medication, the above treatment we also need experts, based on the specific condition of patients approved for consultation, to identify a more complete and accurate comprehensive treatment programs and therapeutic programs for free expert advice

Traditional breast cancer therapy regimen Trinity Green

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Option One: (best treatment for breast cancer without metastasis, combination):
8 + 8 + = 2000 1, Kang Lixin Capsule 8 boxes 8 boxes Huang Wan + West + Gifts = 2000
8 + 15 + = 1500 / 2, Kang Lixin Capsule 8 boxes + compound cantharidin Capsule 15 boxes + gifts = 1,500 yuan / month
10 + 8 + = 3000 / 3 Capsule 10 boxes Shendan Sanjie Pill 8 + West + gift box = 3,000 yuan / month
10 + 15 + = 2600 / 4 Capsule 10 boxes Shendan Sanjie compound cantharidin + + Premium capsule 15 boxes = 2,600 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of     Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule 30 days    1 30 3 gifts a bottle of 30 days.   6 20 4, Se Po capsule 6 in 20 days
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Two: (breast cancer metastasis lung, lymph nodes, bone and other organs such as the best treatment combination):
10 + 15 + = 2600 / 1 Capsule 10 boxes Shendan Sanjie + compound cantharidin capsules 15 boxes + gifts = 2600 yuan / month
10 + 5 + =2600 / 2 Capsule 10 boxes Shendan Sanjie + Qingfei Sanjie Pill 5 boxes + gifts = 2,600 yuan / month
8 + 15 + = 1500 / 3, Kang Lixin Capsule 8 boxes + compound cantharidin Capsule 15 boxes + gifts = 1,500 yuan / month
8 + 5 + = 1500 / 4, Kang Lixin Capsule 8 boxes + box + Qingfei gifts Sanjie Pill 5 = 1500 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of    Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule 30 days   1 30 3, 1 bottle of premium 30 days. 6 20 4, Se Po capsule 6 in 20 days.
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Note: For your complete and early to see the effect of medication, the above treatment we also need experts, based on the specific condition of patients approved for consultation, to identify a more complete and accurate integrated treatment programs and free diet plan expert advice Tel:   Or

Trinity Green gastrointestinal cancer therapy regimen

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Option One: (not transfer the esophagus, stomach, cardia, and colon cancer the best treatment combination):
1, anti-cancer pill 5 boxes + level ZXC 15 boxes + gifts = 3200 yuan / month
2 Capsule 15 boxes cinobufotalin flat pill 5 boxes + cancer + gifts = 3,000 yuan / month
3, 15 Xiaoaiping oral cancer flat pill box + box + gifts = 2000 5 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of       Inquire Offer
FREE: 1, Astragalus particles 6 in 30 days.    2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.    3 gifts a bottle of 30 days.    4, Se Po capsule 6 in 20 days
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Two: (esophagus, stomach, cardia and colorectal cancer dysphagia who appeared the best treatment combination):
1, 15 boxes + ZXC scattered esophageal level 4 boxes + gifts = 3200 yuan / month
2, 4 loose boxes + esophageal level Xiaoaiping oral 15 boxes + gifts = 1800 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of       Inquire Offer
FREE: 1, Astragalus particles 6 in 30 days    2, 1 bottle of Ganoderma lucidum spore powder capsule 30 days     1 bottle of premium 30 days 3 4, 6-selenium Bao capsule for 20 days
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Three: (esophagus, stomach, cardia and colorectal cancer have been transferred by the best treatment combination):
1, 15 boxes + ZXC Level 15 anti-cancer pill box + gifts = 3,600 yuan / month
2, Fu-cancer Capsule 10 boxes + 5 flat pill box + gifts = 2320 yuan / month
3, 15 boxes ZXC + An Kangxin Capsule 10 boxes + gifts = 3,600 yuan / month
4, 15 boxes ZXC + Cinobufotalin + Premium capsule 15 boxes = 3,600 yuan / month
5, Fu-sheng Capsule 10 boxes + 5 Xiaoaiping film box + gifts = 2320 yuan / month
6, anti-cancer pill 5 flat boxes + Xiaoaiping film 5 boxes + gifts = 800 yuan / month
7, 15 boxes ZXC Oral Rehabilitation 27 + gold + gift box = 3,600 yuan / month
8, 15 boxes ZXC + Kang Lixin Capsule 10 boxes + gifts = 3600 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of      Inquire Offer
FREE: 1, Astragalus particles 6 in 30 days    2, 1 bottle of Ganoderma lucidum spore powder capsule 30 days     3, 1 bottle of premium 30 days.    4, Se Po capsule 6 in 20 days.
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts

Chinese medicine treatment of liver cancer therapy regimen Trinity Green

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Option One:(subject toprimary liver cancer or preventmetastasis: pain, jaundice, ascites, loss of appetite and fatigue and sothe best treatment combination):
15 + 10 + = 3000 / 1 Capsule 15 boxes cinobufotalin Capsule 10 boxes + rebirth + Gifts = 3,000 yuan / month
10 + 10 + = 2000 / 2, liver complex capsules Capsule 10 boxes 10 boxes + rebirth + Gifts = 2,000 yuan / month
15 + 10 + = 3200 / 3, 15 boxes + ZXC rebirth Capsule 10 boxes + gifts = 3200 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of    Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days.   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.    1 30 3, 1 bottle of premium 30 days.   6 20 4, Se Po capsule 6 in 20 days.
Note: The above gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Two: (HCC have been transferred the best treatment or prevention of transfer of portfolio):
15 + 5 + = 3200 / 1 ZXC level 15 anti-cancer pill box + box + gifts 5 = 3200 yuan / month
10 + 15 + = 1800 / 2, Chi Capsule 10 boxes + compound cantharidin Capsule 15 boxes + gifts = 1,800 yuan / month
15 + 10 + = 3600 / 3, 15 + back to life ZXC Capsule 10 boxes + gifts = 3,600 yuan / month
10 4, Fu-sheng Capsule 10 boxes + 9 + = 2400 / Liver Complex Capsule 9 boxes + gifts = 2,400 yuan / month
9 5, 9 boxes of liver complex capsules 15 + = 3600 / + ZXC 15 boxes + gifts = 3,600 yuan / month
10 15 + = 3600 / 6, Fu-sheng Capsule 10 boxes of 15 capsules cinobufotalin + boxes + gifts = 3,600 yuan / month
15 7, 15 boxes ZXC 18 + = 3600 / + 18 Xiaoaiping oral gift box + = 3,600 yuan / month
15 8, 15 boxes ZXC 10 + = 3600 / + Kang Lixin Capsule 10 boxes + gifts = 3,600 yuan / month
15 9, 15 boxes ZXC 10 + = 3600 / + An Kangxin Capsule 10 boxes + gifts = 3,600 yuan / month
15 10, 15 boxes ZXC 15 + = 3600 / + Cinobufotalin + Premium capsule 15 boxes = 3,600 yuan / month
5 10 + = 1800 / 11 Xiaoaiping film capsule 5 boxes 10 boxes + + An Kangxin gifts = 1,800 yuan / month
9 10 + = 2400 / 12, Liver Complex Capsules 10 capsules 9 boxes + box + gifts An Kangxin = 2400 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of    Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days.   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.   1 30 3, 1 bottle of premium 30 days.     6 20 4, Se Po capsule 6 in 20 days.
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Note: For your complete and early to see the effect of medication, the above treatment we also need experts, based on the specific condition of patients approved for consultation, to identify a more complete and accurate comprehensive treatment programs and therapeutic programs for free expert advice Tel:   .

Traditional Chinese medicine treatment of lung cancer program trinity

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Option One: (primary lung cancer or prevent metastasisif: cough, chest tightness, shortness of breath, loss of appetite and fatigue and sothe best treatment combination):
10 + 15 + = 3900 / 1, compound Yifei yew capsules 10 boxes + box + gifts Thanh Hoa particles 15 = 3900 yuan / month
5 + 27 + = 2160 / 2,5 boxes Qingfei Sanjie Pill Oral Rehabilitation 27 + gold + gift box = 2,160 yuan / month
15 + 5 + = 2000 / 3, Yifei Thanh Hoa particles 15 5 pill box + box + Qingfei Sanjie gifts = 2000 yuan / month
27 15 + = 3000 / 4, Kim Oral Rehabilitation Yifei Thanh Hoa 27 boxes + box + gifts particles 15 = 3000 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of    Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.   1 30 3, 1 bottle of premium 30 days.   6 20 4, Se Po capsule 6 in 20 days
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Two: (to prevent the transfer or lung cancer with brain metastasis, and chest tightness or pain associated with cough, anorexia and other symptoms in patients with the best treatment combination):
5 + 18 + = 1800 / 1, 5 Qingfei Sanjie Pill Box + javanica oil emulsion of 18 boxes + gifts oral = 1,800 yuan / month
5 6 + = 1800 / 2, Qingfei Sanjie Pill Box + days chicho 5 capsules 6 boxes + gifts = 1,800 yuan / month
18 6 + = 2400 / 3, Brucea javanica oil emulsion of 18 boxes + day oral chicho capsules 6 boxes + gifts = 2400 yuan / month
If pain or pleural effusion, etc. plus Chi Ling capsules, pills dropsical disease, tumor pain, An, Bo Ning and other cancers of      Inquire Offer
1 6 30 FREE: 1, Astragalus particles 6 in 30 days.    1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.     1 30 3, 1 bottle of premium 30 days.   6 20 4, Se Po capsule 6 in 20 days
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Option Three: (to prevent bone metastasis or lung metastasis, lymphatic, digestive, or other such best treatment combination):
15 + 5 + = 3000 / 1 Capsule 15 boxes cinobufotalin + Qingfei Sanjie Pill 5 boxes + gifts = 3,000 yuan / month
8 10 + = 2000 / 2, Kang Lixin Capsule 8 boxes + box + Qingfei gifts Sanjie Pill 10 = 2000 yuan / month
8 15 + = 2500 / 3, Kang Lixin Yifei Capsule 8 boxes + box + gifts Thanh Hoa particles 15 = 2500 yuan / month
5 15 + = 3200 / 4, 5 boxes + Qingfei Sanjie Pill ZXC 15 boxes + gifts = 3200 yuan / month
5 15 + = 3200 / 5, Qingfei Sanjie Pill 5 boxes of 15 capsules cinobufotalin + boxes + gifts = 3200 yuan / month
5 18 + = 1800 / 6, 5 Qingfei Sanjie Pill Box + javanica oil emulsion of 18 boxes + gifts oral = 1,800 yuan / month
18 15 + = 3200 / 7, Box 18 Xiaoaiping oral capsule cinobufotalin 15 + boxes + gifts = 3200 yuan / month
10 15 + = 3200 / 8, Kang Lixin Capsule 10 boxes of 15 capsules + cinobufotalin boxes + gifts = 3200 yuan / month
5 9, 5 Qingfei Sanjie Pill Box 10 + = 1500 / + 10 Xiaoaiping piece gift box + = 1,500 yuan / month
5 10, 5 Qingfei Sanjie Pill Box 15 + = 3000 / + Cinobufotalin + Premium capsule 15 boxes = 3,000 yuan / month
11, pain water         5 Qingfei Sanjie Pill Box + 5 6 + = 2160 / Ling Zhi Capsule 6 boxes + gifts = 2160 yuan / month
1 6 30 FREE: 1, Astragalus particles 6 in 30 days.   1 30 2, 1 bottle of Ganoderma lucidum spore powder capsule for 30 days.   1 30 3, 1 bottle of premium 30 days.   6 20 4, Se Po capsule 6 in 20 days.
Note : These gifts are assisted to improve the efficacy of cancer treatment drugs, where in our office by the drug treatment patients can get to buy any one of a corresponding course of gifts
Note: For your complete and early to see the effect of medication, the above treatment we also need experts, based on the specific condition of patients approved for consultation, to identify a more complete and accurate comprehensive treatment programs and therapeutic programs for free expert advice Tel: or .

Trinity green therapy of lung cancer

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"Trinity green therapy of lung cancer," Introduction: Lung cancer-specific anti-cancer drug + drugs + broad-spectrum trace element products.
 1Lung cancer-specific drugs (oral and Qingfei Jinfukang Sanjie pill): The treatment of lung cancer-specific drugs targeted to achieve effective control of foci and reduce the symptoms of lung cancer.Currently specializes in the treatment of lung cancer-specific oral drug rehabilitation and clearing the lungs of gold Sanjie pills, and minimal side effects these drugs can be avoided, "Gong Yi Du poison" of frail patients with advanced lung cancer of direct damage, so Choose one of them can be preferred.
 2,,,Lung cancer effects of drugs (pain grams): is currently in advanced cancer patients preferred magnetic drug, the drug use is the latest generation of transdermal technology, rapid directional drugs directly through the skin lesions improved survival in patients with pain and quality of production, inparticular, that this operation can not be late radiotherapy chemotherapy Friends also made good effect.
 3, broad-spectrum anti-cancer drugs (oral Xiaoaiping compound cantharidin capsule Xiaoaiping film, Ai Kang Fu will relieve oral solution): The broad-spectrum anti-cancer drugs and treatment not only can strengthen the entire digestive system cancer at the same time effective control of blood and lymph node metastasis and cancer cells of the body of free huge role in the killing, so the transfer has been transferred or have not yet found in patients, it is best to kill cancer cells and useful free treatment drugs, free of cancer cells to reduce or kill the rehabilitation of the patients also can effectively prevent the proliferation and metastasis of cancer cells.Of course, for the weak, poor cardiac function in patients with gastrointestinal drugs selected drugs must pay attention to drug safety, in order to prevent improper medication to the patient's condition worse.
Oncology hospital treatment of cancer has many years of professional experience and history, and have senior experts in the treatment of patients with well-developed program, different patients with different auxiliary agents and trace elements, through our extensive clinical observation, oral liquid herbal Xiaoaiping relatively mild, good physique, and swallowing difficulties for patients to take.6In general, quick capsule compound cantharidin, the effect is better, but for taking the drug every6months to conduct a course of detoxification, so you can avoid the side effects of long-term use, and now the country can not grasp this detoxification method several hospitals, we remind the friends in the purchase of medicines when the majority of patients will choose professional hospital compound on the market today, some three hundred dollars cantharidin capsules before a course, do not covet the moment because the cheap and regret for life.Efficacy and stability Xiaoaiping tablets, side effects are small.According to the specific conditions of patients under the guidance of experts in our chosen medication.
 4, trace element supplement and enhance the body immunity to improve their disease resistance (Western oral Ganoderma lucidum, amino acids, such as oral solution and oral OVA dysphagia, especially those patients taking more convenient): Western Ganoderma oral solution (U.S. imports mixture of ginseng and Ganoderma lucidum) can inhibit tumor growth on the human body to reduce chemotherapy side effects, improve patient's appetite, loss of appetite, especially for patients who have a significant effect.Full complement of amino acids in patients with oral trace elements, improve the immunity of patients with resistance to cancer patients for all phases of long-term use.Liquid egg albumin in patients with extremely low for optimal immunity, particularly those vulnerable patients with cold low-protein, have a good role and efficacy.