Carcinoma with spindle cells and giant cells, this type is further divided into multi-cell carcinoma, spindle cell carcinoma and giant cell carcinoma. Multi-cell carcinoma (pleomorphic carcinoma, also known as pleomorphic carcinoma): Pleomorphic carcinoma is poorly differentiated non-small cell carcinoma, rare. Men more common, occurs in the elderly, peak age of 50-70 years. Most patients with long-term smoking history. Clinical symptoms of cough, sputum, chest pain, hemoptysis, and the affected side. In squamous cell carcinoma, adenocarcinoma or large cell carcinoma containing spindle cells and (or) giant cells; or only by the spindle cell carcinoma and giant cells. Both collectively referred to as pleomorphic carcinoma.
Pleomorphic spindle cell carcinoma and (or) giant cell components can not be less than 10% of total cancer, or only a diagnosis of poorly differentiated adenocarcinoma or poorly differentiated squamous cell carcinoma. In the diagnosis of pleomorphic carcinoma, adenocarcinoma and squamous cell carcinoma occur, should be given to identify, such as pleomorphic carcinoma (with squamous cell carcinoma or adenocarcinoma). There special treatment of large cell carcinoma, you do not particularly marked, because in the pleomorphic, small focal presence of large cell carcinoma is very common. Pleomorphic carcinoma component appears in a small fine brush, then known as the composite of small cell carcinoma.
Introduction of multi-cell carcinoma of the lung pleomorphic carcinoma general examination: The tumor can occur in the left lung and upper and lower lobes. Located in the central lung (central type), can also be located in the peripheral lung (peripheral type). Or fish samples from the cut surface, showing hemorrhage and necrosis; tumor and surrounding lung tissue boundaries unclear.
Introduction of multi-cell carcinoma histological features : components of these tumors have a variety of different combinations to form complex: conformational features are: low degree of differentiation, composition and diverse, complex structures. Specifically, adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, large cell carcinoma, spindle cells and giant cells.
Introduction of multi-cell carcinoma immunohistochemistry: pleomorphic carcinoma of epithelial markers such as CK and the IMA, all the epithelial component is diffuse and strong positive expression; and spindle cells and giant cells positive for juice expression. Mesenchymal markers (vimenti when the negative expression of epithelial component; and spindle cells and giant cells are also part of the cells positive. Immunohistochemistry in pleomorphic carcinoma, mainly: with epithelial markers confirmed whether spindle cell carcinoma differentiation; distinguish tissue sarcoma in the presence of heterologous elements, such as rhabdomyosarcoma.
Pleomorphic carcinoma: To note the following several principles: a. white blood cells contained in non-small cell carcinoma and giant cell carcinoma of the total amount of not less than 10%; b. epithelial markers in cancer, positive expression was determined, and Whether spindle cells are positive, does not affect the polymorphisms may break; c. cancer HE sections or immunohistochemistry heterologous sarcoma components do not exist. Once cancer of small cell carcinoma, is attributable to the complex nature of small cell carcinoma.
Prognosis: Pulmonary pleomorphic carcinoma with poor prognosis, lung cancer, polymorphism in the prognosis of NSCLC in general there is no statistical difference.