Differential diagnosis of pleomorphic carcinoma

By | March 28, 2012

Differential diagnosis of multi-cell carcinoma: pleomorphic lung cancer should be identified with the following tumor.
Differential diagnosis of pleomorphic carcinoma a. lung sarcoma: the WHO 3rd edition (1999) stressed that only category among cell carcinoma and sarcoma components appear heterogeneity, such as osteosarcoma, chondrosarcoma, and stripes and yang, etc., to diagnose lung sarcoma.
Differential diagnosis of pleomorphic carcinoma b. Pulmonary blastoma: Pulmonary pleomorphic carcinoma, adenocarcinoma may be present and spindle cell structure with pulmonary blastoma were similar. However, the lung epithelial pleomorphic poorly differentiated carcinoma, adenocarcinoma or squamous cell carcinoma, whether obvious atypia, which is different from the composition of lung epithelial tumor cells. Pulmonary pleomorphic carcinoma of spindle cells and giant cell tumor of the lung is different from the original mesenchymal components, and pulmonary blastoma of mesenchymal-derived ingredients may be associated with striated muscle differentiation and malignant bone and cartilage components.
Pleomorphic carcinoma c. differential diagnosis of giant cell malignant fibrous histiocytoma (G-MFH): Pleomorphic carcinoma of the lung if the spindle cell carcinoma and giant cell carcinoma of the composition, the morphology is similar to epithelial markers such as CK , EMA, diffuse positive tumor cells; the latter expression was negative or small focal weak positive. Cell antigen markers, such as Mac387, and (or) AACT, lysozyme, etc., the former individual cells positive; the latter either spindle cells or giant cells were identified can be positive. In addition, G-MFH routine HE sections, the spindle tumor cells were seats striated (storifonn) structure, there are more yellow tumor cells and inflammatory cells, which is different from the pulmonary pleomorphic carcinoma.
Differential diagnosis of pleomorphic carcinoma d. large cell carcinoma and spindle cell carcinoma: pleomorphic lung cancer when the spindle cells and giant cells, similar to the large cell carcinoma or spindle cell carcinoma. But the latter uniform structure, a single cell. This differs from the pleomorphic carcinoma of the lung.
In addition, pleomorphic carcinoma of the lung should be poorly differentiated adenocarcinoma, poorly differentiated carcinoma and poorly differentiated adenosquamous carcinoma identified.

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