Activation of the PI3K/AKT signal pathway is a known driver of the progression of prostate cancer to the castrate-resistant stage, the most lethal form of prostate cancer. Using a genome-wide genetic screen, Dr…
Fibroadenomas are the most common benign breast tumors in women of reproductive age, affecting thousands of women in Singapore each year. …
The findings, published July 3 in Cancer Cell, contribute to the increasing acknowledgement that the cells and tissue surrounding a tumor — the stroma — are an integral part of cancer initiation, growth, and expansion. “Our study reveals a precise mechanism that stromal cells use to encourage the tumorigenesis of epithelial cancer cells,” said Jorge Moscat, Ph.D., director of the Cell Death and Survival Networks Program at Sanford-Burnham. “We have shown that in the stroma, p62 acts as an anti-inflammatory tumor suppressor, controlling the inflammatory environment and the signals that promote cancer…
To better understand how cancer develops, scientists strive to identify genetic factors — whether hereditary or acquired — that could serve as the catalyst or trigger for tumor progression. Until now, the genetic basis of cancers had only been examined in the coding regions of the genome, which constitutes only 2% of it. …
Dohlman, a professor of biochemistry and biophysics in the UNC School of Medicine, is like a mechanic for cells. He takes them apart to see how they function. He can tell you what part is like a gas pedal — a protein that pushes a brain chemical into action, for instance. And he can tell you which part is like the brakes — a protein that counteracts the effect of the gas pedal…
Writing in the International Journal of Low Radiation, Faruck Lukmanul Hakkim of the University of Nizwa, Oman and Nagasaki University, Nagasaki, Japan, and colleagues there and at Macquarie University, New South Wales, Australia, Bharathiar University, India and Konkuk University, South Korea, explain how three ubiquitous and well-studied natural products derived from plants can protect the skin against gamma radiation during radiotherapy. Hakkim and colleagues discuss the benefits of the organic, antioxidant compounds caffeic acid (CA), rosmarinic acid (RA) and trans-cinnamic acid (TCA) used at non-toxic concentrations. They tested the radio protective effect of these compounds against gamma-radiation in terms of reducing levels of reactive oxygen species generated in skin cells by clinical relevance dose of gamma ray in the laboratory and in terms of the damage to the genetic material DNA, specifically double strand breaks in laboratory samples of human skin cells (keratinocytes). …
source : http://www.sciencedaily.com/releases/2014/07/140717124836.htm
source : http://www.sciencedaily.com/releases/2014/07/140703142417.htm
source : http://www.sciencedaily.com/releases/2014/06/140627145932.htm
source : http://www.sciencedaily.com/releases/2014/06/140624105845.htm