Tag Archive apc

Cryptic clues drive new theory of bowel cancer development

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The researchers produced evidence that stem cells are responsible for maintaining and regenerating the ‘crypts’ that are a feature of the bowel lining, and believe these stem cells are involved in bowel cancer development, a controversial finding as scientists are still divided on the stem cells’ existence. Using 3D imaging technologies, Dr Chin Wee Tan and Professor Tony Burgess from the Structural Biology division at the Walter and Eliza Hall Institute showed for the first time the bowel generates new intestinal crypts by a process called ‘budding’. The finding overturns the existing theory of how intestinal crypts form, with significant implications for our understanding of bowel cancer development. Intestinal ‘crypts’ are pocket-like wells in the bowel wall that produce mucous and absorb nutrients and water…

Genetic modifier affects colon tumor formation

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Neufeld, associate professor in the Department of Molecular Biosciences, studies the adenomatous polyposis coli protein, which protects against colon cancer. Many of her experiments involve testing mice with APC mutations, which cause colon cancer, and seeing if any new drug compounds will work against the mutations…

Genetic modifier impacts colon tumor formation

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Dr. Neufeld studies the adenomatous polyposis coli (APC) protein, which protects against colon cancer. Many of her experiments involve testing mice with APC mutations (which cause colon cancer) and seeing if any new drug compounds will work against the mutations…

Gut microbes turn carbs into colorectal cancer, study shows — ScienceDaily

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source : http://www.sciencedaily.com/releases/2014/07/140717124836.htm