RNA interference is a natural process by which RNA molecules inhibit gene expression, but it can also be used by scientists to block a gene’s function and look for those that contribute to certain diseases. "For years, fruit flies and worms have been great model organisms because of the ability to carry out rapid genetic screens," says Elaine Fuchs, Rebecca C…
A robot that worms its way in The median survival rate for patients with glioblastomas, or high grade primary brain cancer, is less than two years. One factor contributing to this low rate is the fact that many deep-seated and pervasive tumors are not entirely accessible or even visible when using current neurosurgical tools and imaging techniques. But several years ago, J. …
"Our finding provides a target to prevent these rearrangements, so we could conceivably prevent cancer in some high-risk people," said senior author Edward P. (Paul) Hasty, D.V.M., of the School of Medicine at The University of Texas Health Science Center at San Antonio. …
Scientists at The Institute of Cancer Research, London, found a genetic variant that influences the ageing process among four new variants they linked to myeloma — one of the most common types of blood cancer. …
Each mutational process leaves a particular pattern of mutations, an imprint or signature, in the genomes of cancers it has caused. By studying 7,042 genomes of people with the most common forms of cancer, the team uncovered more than 20 signatures of processes that mutate DNA…
"NatA appears essential for the growth of cells and their ability to divide, and we can see elevated production of this enzyme in many forms of cancer" said Ronen Marmorstein, Ph.D., senior author, Hilary Koprowski, M.D. Professor, and leader of The Wistar Institute Cancer Center’s Gene Expression and Regulation program…
In contrast to standard therapies for heart failure, JQ1 works directly within the cell’s command center, or nucleus, to prevent damaging stress responses. This groundbreaking research lays the foundation for an entirely new way of treating a diseased heart…
The identification of CPTP was the result of an international collaboration that built on prior research by co-lead author Charles Chalfant, Ph.D., Endowed Chair of Cancer Cell Signaling and member of the Cancer Cell Signaling program at Virginia Commonwealth University Massey Cancer Center as well as professor in the Department of Biochemistry and Molecular Biology at VCU School of Medicine. The team discovered that CPTP regulates levels of biologically active lipids, which are molecules such as fatty acids that often play a role in cell signaling…
They show how the cells, which are responsible for fighting infections and cancer in the human body, change the organisation of their surface molecules, when activated by a type of protein found on viral-infected or tumour cells. Professor Daniel Davis, who has been leading the investigation into the immune cells, known as natural killers, said the work could provide important clues for tackling disease…
Now, in this week’s issue of Cell Stem Cell, the Salk Institute’s Juan Carlos Izpisua Belmonte and his colleagues show that the recipe for iPSCs is far more versatile than originally thought. For the first time, they have replaced a gene once thought impossible to substitute, creating the potential for more flexible recipes that should speed the adoption of stem cells therapies…