Tag Archives: southwestern

Study identifying cell of origin for large, disfiguring nerve tumors lays groundwork for development of new therapies

“This advance provides new insight into the steps that lead to tumor development and suggests ways to develop therapies to prevent neurofibroma formation where none exist today,” said Dr. Lu Le, Assistant Professor of Dermatology at UT Southwestern and senior author of the study, published online and in Cancer Cell…

‘Achilles heel’ in metabolic pathway identified, could lead to new treatments for lung cancer

At the heart of this pathway lies PPARγ (peroxisome proliferation-activated receptor gamma), a protein that regulates glucose and lipid metabolism in normal cells. Researchers demonstrated that by activating PPARγ with antidiabetic drugs in lung cancer cells, they could stop these tumor cells from dividing. “We found that activation of PPARγ causes a major metabolic change in cancer cells that impairs their ability to handle oxidative stress,” said Dr…

Rare stem cells hold potential for infertility treatments

Researchers studying infertility in mouse models found that, unlike similar types of cells that develop into sperm, the stem cells that express PAX7 can survive treatment with toxic drugs and radiation. If the findings hold true in people, they eventually could lead to new strategies to restore or protect fertility in men undergoing cancer treatment. “Unfortunately, many cancer treatments negatively impact fertility, and men who receive such treatments are at high risk of losing their fertility…

Less can be more when removing lymph nodes during breast cancer surgery

In the Oct. 2 edition of the Journal of the American Medical Association, lead author Dr. Roshni Rao, associate professor of surgery at UT Southwestern, and other investigators from the Harold C. Simmons Cancer Center reviewed studies on patient outcomes of women who had received various forms of surgical treatment, ranging from removal of one lymph node to prevent the spread of breast cancer to removing the entire network of lymph nodes spanning the armpits…