Tag Archives: scientific

No viral cause for breast cancer and brain tumors

It has been scientifically proven that about 15 per cent of all cancer cases are the result of viral infection, but many researchers believe that even more cancers could be caused by viruses. Among other theories, it is suggested that the Epstein-Barr virus could be a possible cause of breast cancer and that the cytomegalovirus might cause the malignant brain tumour glioblastoma. Extremely comprehensive study "There is some controversy in that we have not found any viruses in these forms of cancer, but if there were any viral involvement in breast cancer and glioblastoma, it is likely that we would have found some trace of it…

First-ever view of gene activity, transcript patterns in single human cells

Whenever cells activate a gene, they produce gene specific transcript molecules, which make the function of the gene available to the cell. The measurement of gene activity is a routine activity in medical diagnostics, especially in cancer medicine. Today’s technologies determine the activity of genes by measuring the amount of transcript molecules. …

New knowledge on molecular mechanisms behind breast cancer

Researchers are constantly trying to learn more about the body’s advanced communication processes. Receptors serve as a kind of switchboard in the cell, which connects specific signaling proteins to specific cellular functions. Using state-of-the-art technology, researchers at University of Copenhagen have studied a special cell surface receptor of major importance for health and disease…

New insights into the ribosome; important implications for disease

But in recent years, it has been demonstrated that the ribosome is far more than just a processing unit; indeed, current research points to an important role for this complex structure in actively regulating biological processes. Now, in a first-of-its-kind study that broadly examines the composition of the riboproteome, a scientific team led by investigators at Beth Israel Deaconess Medical Center (BIDMC) reveals previously unappreciated components of the ribosome, uncovering a large and dynamic structure that, among other things, can be altered in cancer. Published in today’s on-line issue of the journal Cell Reports, the study additionally describes the development of an analytic platform that can be widely applied to numerous biological systems to highlight the functional roles of possible disease genes associated with the riboproteome. "A primary goal of our lab is to gain a better understanding of translation and its impact on cancer," explains senior author Pier Paolo Pandolfi, MD, PhD, Scientific Director of the Cancer Center at BIDMC and George C…

Vitamin C helps control gene activity in stem cells

The researchers found that vitamin C assists enzymes that play a crucial role in releasing the brakes that keep certain genes from becoming activated in the embryo soon after fertilization, when egg and sperm fuse. The discovery might eventually lead to the use of vitamin C to improve results of in vitro fertilization, in which early embryos now are typically grown without the vitamin, and also to treat cancer, in which tumor cells abnormally engage or release these brakes on gene activation, the researchers concluded in a study published June 30, 2013 in the journal Nature. In the near term, stem-cell scientists may begin incorporating vitamin C more systematically into their procedures for growing the most healthy and useful stem cells, according to UCSF stem-cell scientist Miguel Ramalho-Santos, PhD, who led the study. In fact, the unanticipated discovery emerged from an effort to compare different formulations of the growth medium, a kind of nutrient broth used to grow mouse embryonic stem cells in the lab…

No science behind blood-type diets, researchers say

They are a fad that refuses to fade, but no solid evidence exists to show whether or not eating plans tailored to ABO blood types promote health, say Belgian researchers who tried their best to find some. After sifting through the scientific literature, researchers identified just one indirectly related study - it looked at the effects of low-fat diets on cholesterol levels in people with different blood types - and even that one was weak, they concluded. Some studies have found links between blood type and risk for developing blood clots or certain cancers, of having a heart attack and of hemorrhaging when infected with Dengue fever. But no peer-reviewed research has indicated that eating foods supposedly compatible with one's blood type will improve health or induce weight loss more than a general diet plan. Medical professionals already knew this, according to the study's senior author, Dr. Philippe Vandekerckhove at the Belgian Red Cross-Flanders in Mechelen. “However, the general populace have access to blood type diets, regardless of medical guidance, and cannot be expected to be able to determine whether or not the health claims are, in fact, ‘evidence-based',” Vandekerckhove said. Blood type is determined by proteins on the surface of red blood cells and antibodies in the blood. The most familiar grouping, known as ABO blood types, refers to whether a person's cells carry the proteins known as A or B, or both of them, or neither of the two - which is designated blood type O. The idea that blood type influences an individual's life - and even personality - is popular in parts of Asia. In 2011, for example, a Japanese politician apologized for a rude remark he had made about tsunami victims by blaming his blood type. But blood type eating regimens are often premised on the theory that blood group signals a population's evolutionary background - primarily agrarian or hunter-gatherer, for instance - and that ancient history inclines people of certain blood types to thrive or suffer when eating one kind of diet or another. Vandekerckhove's team, who published their results in The American Journal of Clinical Nutrition, searched the largest online databases of published research for clinical trials, reviews and all other types of studies for reports about people grouped by blood type following specifically prescribed diets. Of 1,415 articles that initially turned up in the search, 16 looked promising at the start but 15 of those were discarded on closer analysis when the authors saw that they were poorly designed. Only one was relevant to the topic and strong enough to be included in an analysis because it was a randomized controlled trial. But it had several other weaknesses, including the fact that participants knew which group they had been assigned to, the group sizes were small, and the main endpoint assessed was “bad cholesterol” levels, which doesn't directly address the question of health or weight. Vandekerckhove and his coauthors were surprised and disappointed to find that no studies had been done that actually addressed the question, he said. “Until a study has been performed which recruits people with a certain blood type who have adhered to the diet, compared with those of the same blood type who have not adhered to the diet, and the incidence of disease/measurement of health can be assessed, then the health effects of a blood type diet are not proven,” he wrote in an email. “Currently, there is no evidence to support that ‘Blood Type Diets' have any effect on positively benefiting your health,” said Beth Warren, a registered dietician in New York City who was not involved in the study. “The fad diet was only made popular by a book during 1996…with no evidence to support it,” Warren said. “Eat Right 4 Your Type” by Peter D'Adamo has more than 7 million copies in print, and outlines a theory about which foods are best for people with the various ABO blood types to eat and which to avoid. D'Adamo says he believes in the diet based on circumstantial evidence. “All the authors did was conclude, as have I, that there is a lack of direct research on the subject,” D'Adamo said by email. He too would like to see direct research on the diets, but such studies are unlikely because they would be too costly. One-size-fits-all diets don't make sense either, D'Adamo said, and it may be that blood type is one way to predict which general weight loss diets work better for which people. “We hope the results of this systematic review will reinforce the need for individuals and companies to take responsibility of their claims and clearly differentiate between something that is “evidence-based” rather than something that is “theoretical”,” Vandekerckhove said. “We have to be very careful when we hear of fad diets and look into if and how this way of eating benefits our health and goals for weight-loss and maintenance,” Warren said. “In this case, we cannot say that it does at this time,” she said.source : http://www.foxnews.com/health/2013/05/31/no-science-behind-blood-type-diets-researchers-say/

ADHD medications not tied to drug, alcohol abuse

Taking Ritalin and other drugs for attention-deficit/hyperactivity disorder (ADHD) doesn't affect a child's chances of trying or abusing alcohol and drugs later in life, a new review suggests. Researchers pooled data from 15 studies that included a total of 2,600 kids and teenagers with ADHD who were or were not medicated with stimulants and were followed for anywhere from 3 to 28 years. They found no clear difference in how many participants started using or abusing alcohol, cigarettes, marijuana or cocaine, based on how their ADHD was managed. “The scientific evidence suggests that the risk for alcohol and substance problems later in development, in adolescence or adulthood, doesn't seem to be strongly tied to whether or not children were previously… treated with stimulant medication,” said psychologist Steve Lee, who worked on the new study. That means parents should focus on discussing more immediate effects of stimulants with their child's doctor, such as sleep or appetite problems, he added. Kids with ADHD are known to be at higher risk of developing substance problems than those without the disorder. One analysis from 2003 suggested kids treated with stimulants were less likely to develop alcohol and drug problems than their peers with ADHD. Lee and his colleagues from the University of California, Los Angeles, wanted to see how that picture looked once more recent studies were taken into account. The researchers analyzed data related to substance use or abuse of each drug separately. For every category they looked at - alcohol, nicotine, marijuana, cocaine and other drugs - Ritalin and similar stimulants weren't tied to a clear increase or decrease in future use or abuse. That finding isn't the end of the story, the study team said. For example, it's not clear whether the effects of stimulants are different for boys and girls. And because kids in these studies were not randomly assigned to take stimulants or not, it's possible they varied in other ways that may have affected future drug and alcohol use, such as ADHD severity, the researchers write in JAMA Psychiatry. “What I say to parents when I'm talking to them about medication is, the medication is unlikely to have any adverse effects on substance use as far as we know right now,” said William Pelham, head of the Center for Children and Families at Florida International University in Miami, who wasn't involved in the new study. But, he said, “We don't have a lot of studies going into the full range of years when people (are most at risk for) substance abuse.” According to the U.S. Centers for Disease Control and Prevention, parent reports suggest that close to one in 10 kids and teens in the U.S. has ever been diagnosed with ADHD, and two-thirds of those with a current diagnosis are treated with medication such as stimulants. Those drugs can come with short-term side effects, including appetite loss and stomach aches. Because of that, “psychosocial, parent-management types of strategies probably ought to be the first line of treatment,” rather than medication, Lee said. In general, stimulants haven't been shown to have long-term side effects in the years after kids stop taking them, Pelham said - but they also don't seem to have long-term benefits. He agreed with Lee that parents should be looking to non-drug ways to improve the outlook for children with ADHD, including working closely with teachers as kids grow up. And because those youth are at higher risk of drug and alcohol problems due to their ADHD, they should have access to programs to improve decision-making skills and peer relationships, Pelham said.source : http://www.foxnews.com/health/2013/05/30/adhd-medications-not-tied-to-drug-alcohol-abuse/