Tag Archives: researchers

Pesticide exposure tied to Parkinson’s disease

Need another good reason to go organic? According to data published in the journal Neurology, exposure to weed killer, solvents and pesticides increases people’s risk for Parkinson’s disease by 33 to 80 percent, Medical Daily reported. Researchers collected data from 104 studies from around the world to analyze how pesticides, insecticides, weed killers, and many other agricultural chemicals influenced an individual’s risk for Parkinson’s disease. Though researchers found links between many chemicals and Parkinson’s, they found no link between Parkinson’s and the chemical dichlorodiphenyltrichloroethane (DDT), which has been banned in the United States for decades, Medical Daily reported. However, people who were exposed to the weed killer paraquat or the fungicides maneb and mancozeb had a two-fold greater risk for contracting the disease. Additionally, researchers showed a direct link between the length of time people were exposed to pesticides and their likelihood of contracting Parkinson’s. The data also indicated that agricultural workers had a 33 percent higher risk of developing Parkinson’s disease than people who didn’t work in agriculture.  The study did not distinguish between people who came in contact with pesticides through their skin or through breathing the chemicals. Parkinson's disease is a neurological condition, characterized by a decrease of the brain’s ability to produce the neurotransmitter dopamine, which ultimately leads to tremors and a decrease in motor control.  Treatment options for Parkinson’s patients are limited. Click for more from Medical Daily.source : http://www.foxnews.com/health/2013/05/28/pesticide-exposure-tied-to-parkinsons-disease/

Lung cancer screening: CT scans more effective than X-rays

Screening for lung cancer using low-dose computed tomography (CT scans) rather than chest X-rays may be a more effective way of detecting the disease, Medscape Today reported. Researchers hope that these results, collected as part of the National Lung Screening Trial, will provide more detailed information about the benefits of various types of lung cancer screening available to patients and physicians. During the study, 26,309 participants received low-dose CT scans, and 26,035 participants underwent chest radiography to detect for signs of lung cancer. Among those who received CT scans, a total of 7,191 participants (27.3 percent) had a positive screening result, compared to 2,387 (9.2 percent) in the chest X-ray group. Overall, lung cancer was diagnosed in 292 participants (1.1 percent) in the CT group compared with 190 (0.7 percent) in the radiography group. Previously, experts had been concerned that the high level of false-positive screenings that occur during CT scans would lead to undue stress, unnecessary testing and high medical bills for patients, Medscape Today reported. However, the new report reveals that the majority of patients who had a positive result after their CT scan only underwent one additional diagnostic test. “In many of the previous analyses people have assumed that there would be three or four or five additional diagnostic tests for every positive screen, and this has ramifications for the cost effectiveness of screening,” study author Dr. William C. Black, professor of radiology at the Dartmouth-Hitchcock Medical Center in Lebanon, N.H., told Medscape Today. Black is hopeful that these results will provide a good frame of reference for other lung cancer screening programs. “If patients and their clinicians are trying to decide whether or not to get screened, they can always refer to these results. They will let patients know what they can expect, what are the likely outcomes, not just in terms of dying of lung cancer, which is only going to happen to a small percentage of people who get screened, but also in terms of the false positives and what happens afterwards,” Dr. Black told Medscape Today. People eligible for lung cancer screening include men and women, ages 55 to 74, who have a 30-pack-per year history of smoking, those who have quit smoking in the last 15 years and those who are medically fit for surgery. Click for more from Medscape Today.source : http://www.foxnews.com/health/2013/05/23/lung-cancer-screening-ct-scans-more-effective-than-x-rays/

Feet contain most fungi on body, new research shows

A new map of the fungal species lurking on human skin reveals the most diverse communities can be found on — you guessed it — the bottom of the feet. Genetic sequencing found the fungal genus Malassezia dominated on most of the core body regions and arms. The heel, toenail and toe web (skin between the toes), by contrast, supported highly varied fungal communities. Imbalances in these populations may lead to athlete's foot and other fungal diseases, the researchers say. The skin serves as a barrier to pathogenic microorganisms, but is also home to a rich array of harmless microbes. Until now, most efforts to study the skin's microorganisms have focused on bacterial species, but fungi (which are a distinct biological group) form a significant part of these skin communities. Feet love fungi In the study, scientists took skin scrapings from 10 healthy adults at 14 different sites on the body. They sequenced the DNA from the swabs. In addition, the researchers isolated more than 130 fungal strains from the genera Malassezia, Penicillium and Aspergillus, and grew them in the lab.   The genus Malassezia, which may cause dandruff, was the most abundant type of fungus at all 11 core-body and arm sites, results showed. These areas included the inner elbow, palm, space between the eyebrows, back of the head, nostril and forearm, among other spots. Core-body sites, such as the chest and abdomen, had the fewest types of fungi, ranging from two to 10 genera. The three foot sites — heel, toenail and toe web — contained much greater fungal diversity, with populations of Malassezia¸ Aspergillus, Cryptococcus, Rhodotorula and Epicoccum, among others. Overall, the heel had the most diverse fungal makeup, with about 80 fungal genera. One study participant had an especially diverse array of fungi. This person had taken a course of oral antifungal medication for a toenail infection seven months prior to the study. The unusual fungal diversity suggests that either an imbalance in the fungal community was causing the stubborn toenail infections, or that changes in the microbe composition due to the medication continued even seven months after stopping treatment, the researchers say. The results demonstrate that human skin is capable of harboring a highly varied fungal population. When fungi go awry The researchers also sequenced bacteria on the skin. The results confirmed previous findings for skin bacterial makeup in healthy people. In contrast to fungal populations, the most diverse bacterial populations were found on the arms. The person with abnormal fungal diversity appeared to have a normal distribution of bacteria. The study of the skin's native fungi has important implications for infection and disease. About 20 percent of the study participants showed signs of possible foot fungal infections, and previous studies have shown up to 60 percent of healthy people may harbor such infections. Fungal infections affect 29 million North Americans. Several factors influence the prevalence of fungal infections, including population and climate. Antifungal medications can have dangerous side effects, and new treatments that target fungal imbalances are needed, the researchers say. The findings were reported online May 22 in the journal Nature.  source : http://www.foxnews.com/health/2013/05/22/feet-contain-most-fungus/

Could eating less save your brain? Study shows reducing calories delays nerve cell loss

Calorie restriction may not always be fun, but cutting back has benefits beyond even weight loss. Studies have shown that eating less can help slow aging, prolong life and even decrease the effects of diseases like Alzheimer’s in a variety of organisms. Based on this knowledge, a group of researchers from the Massachusetts Institute of Technology (MIT) decided to dig further and ask: Could calorie restriction also delay nerve cell loss in the brain – and the changes in learning and memory that go along with it? “We reasoned – and other folks reasoned – that because cognitive decline and neurodegeneration are characteristics of the aging process, that calorie restriction might also work in the brain to slow neurodegeneration,” lead study author, Dr. Johannes Gräff from the Picower Institute for Learning and Memory at MIT, and Howard Hughes Medical Institute, told FoxNews.com. Gräff and his colleagues tested their theory using a group of mice engineered to experience rapid neurodegeneration. Researchers decreased half of the mice’s calorie intake by 30 percent and kept the remaining mice on a normal diet. After three months, researchers tested the learning and memory skills in each group of mice, expecting to see a decline in both cognitive areas. However, while the mice eating normally showed evidence of significant learning and memory deficits related to nerve cell loss, the calorie-restricted mice showed no defecits in their learning or memory skills. “That was one of the first experiments we did, and that was quite promising and cool that it worked,” Gräff said. In the next phase of the study, researchers took a more in-depth look at the brains of both groups of mice. “What we further did was to look through the brains to check the extent or amount of neurodegeneration, and what we found was that neurodegeneration had been slowed down by calorie restriction,” Gräff said. Researchers were curious if reduced neurodegeneration could still be achieved by utilizing proteins activated during calorie restriction – without actually restricting calories. Eventually, they targeted an enzyme called Sirtuin 1 (SIRT1). “This protein is one candidate that has been known to be more abundantly expressed as a result of calorie restriction in our tissues,” Gräff said. The scientists then gave a separate group of mice, also engineered to experience rapid neurodegeneration, a pharmacological dose of SIRT1, without restricting their calorie intake. These mice experienced the same effects as the calorie-restricted mice, showing slower rates of nerve cell loss and no learning or memory deficits after a three-month period. Graff noted that more research needed to be done in this area, and he hopes to further explore the relationship between calorie restriction, SIRT1 and neurodegeneration. “We have the choice – (to look into how) to reduce calorie intake in order to slow onset of neurodegeneration, or we look to this pharmacological activator (to do the same thing),” Gräff said. “Do you want to engage more into reducing caloric intake or revert to pharmacological means for the same effect?” This study is published in the May 22nd issue of The Journal of Neuroscience.source : http://www.foxnews.com/health/2013/05/22/could-eating-less-save-your-brain-study-shows-reducing-calorie-intake-delays/

Kava plant may treat anxiety

An extract from the kava plant can treat people with chronic anxiety, an study from Australia finds. Patients with generalized anxiety disorder who took kava extract tablets for six weeks showed a significant reduction in their symptoms, compared with a control group that took placebo pills, the results showed. The study confirms previous findings showing the anti-anxiety effects of kava, a psychoactive plant native to the Pacific region. Kava is culturally important among many Pacific Islanders, and is used in rituals and ceremonies. Consuming kava may induce a mild sedation and euphoria, a numbing effect and enhanced social interaction. It is prepared in various forms, such as grinding the plant or brewing its roots. It's believed the roots contain chemicals that may treat anxiety. The active ingredients of the plant are compounds called kavalactones. These chemicals have similar effects to medications such as Xanax, which are used to treat anxiety and panic disorders. In the new study, 75 patients with anxiety disorders were given either kava or placebo pills, and their anxiety levels were regularly assessed over the next six weeks. Patients who consumed kava tablets showed significant improvements in their symptoms, as measured by a commonly used psychological test. By the end of the experiment, 26 percent of kava-consuming patients were in remission from their symptoms compared with 6 percent of the placebo group, according to the study, which was published this month in the Journal of Clinical Psychopharmacology. Kava is less addictive and has a lower risk of side effects compared with conventional anxiety medications, according to the study. In the study, some people taking kava reported headaches, but no other side effects were seen. Previous studies have suggested the plant may have negative effects on the liver, but liver tests in the study participants showed no problems. Researchers also found that peoples genetics may affect their response to kava. Genes that code for proteins that transport a brain chemical called GABA may play a role in this, . If this finding is replicated, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking kava, said Jerome Sarris, study author from the University of Melbourne. The new study adds to the evidence of kava's medicinal potential. A 2010 reviewof 12 controlled trials concluded that kava is likely to be an effective treatment for anxiety, and its short-term use is likely to be safe. The reviewers, however, called for larger studies to bolster these results. Kava is a major export of the Pacific. It was once banned in some Western countries, primarily out of concern for its alleged effects on the liver. It is now legal in most places and available in various forms, such as in relaxation supplements and anti-energy drinks. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/20/kava-plant-may-treat-anxiety/

Lifestyle change may ease heart risk from job stress

Being under stress at work is tied to a higher risk of heart problems, new research confirms - but putting down the beer bottle and going for a walk may help. Researchers found that job strain - defined as having a lot of demands at work, but little control - was tied at a 25 percent higher chance of having a heart attack or dying of heart problems. But heart risks were cut in half among people - stressed or not - who maintained a healthy lifestyle compared to those who drank, smoked or were obese. “For many people avoidance of work stress is unrealistic,” lead researcher Mika Kivimaki, from University College London, said in an email. “Thus, we wanted to ask the question whether adopting an otherwise healthy lifestyle would reduce heart disease risk among those with job strain,” he said. Kivimaki and his colleagues combined the results of seven European studies that surveyed 102,000 people about their general lifestyle habits and health, including how much strain they were under at work. None of those participants had heart disease at the start of the study. Over the next seven years, on average, there were about 1,100 heart attacks or deaths from heart disease across the trials. About one in six people in the studies initially reported being under job strain. Rates of heart problems over a decade ranged from 12 cases per 1,000 generally healthy people without job strain to 31 per 1,000 people with job strain and multiple lifestyle risks, such as rarely exercising or having more than three or four alcoholic drinks a day. Kivimaki's team calculated that close to 4 percent of all heart attacks and heart disease deaths could be attributed to job strain and about 26 percent to drinking, smoking, obesity and lack of physical activity. The researchers wrote in the Canadian Medical Association Journal that for people with stressful jobs, adopting a healthier lifestyle may be a strategy to lower heart risks. “We hope this message reaches those who want to reduce their heart disease risk but feel they cannot avoid work stress,” Kivimaki said. One researcher who has studied work stress and heart disease separately said the new review may underestimate the link between job strain and heart disease. OTHER FACTORS? Paul Landsbergis of SUNY Downstate Medical Center in Brooklyn, New York, said other types of job stress that may influence heart risks - such as having low social support and job insecurity - weren't taken into account. The new study doesn't prove pressure at work caused heart problems. But cardiologist Dr. Vincent Figueredo from Jefferson Medical College in Philadelphia said the results are in line with past studies suggesting that chronic stress, including from job strain, can have negative health effects. “With chronic stress, there's activation of these systems that can have long-term effects on things like insulin resistance, central obesity (and) high blood pressure,” Figueredo, who wasn't involved in the new research, said. What this review adds, he said, is that workers may be able to do something about those extra risks. “It does offer some hope for those people who do have that job strain they can't do anything about at work,” Figueredo said. “If you're stuck being stressed at work, at least go out and exercise, don't smoke and eat healthy.”source : http://www.foxnews.com/health/2013/05/17/lifestyle-change-may-ease-heart-risk-from-job-stress/

Majority of pools are contaminated by poop, CDC says

There's poop in public pools, according to a new report. Researchers at the Centers for Disease Control and Prevention (CDC) found genetic material from E. coli bacteria in 58 percent of public pools they tested during the summer of 2012. This shows that “swimmers frequently introduced fecal material into pools,” which could spread germs to other people, the researchers wrote in their report. E. coli bacteria are normally found in the human gut and feces. They also found genetic material from bacteria called Pseudomonas aeruginosa, whichcan cause skin rashes and ear infections, in 59 percent of pools. The fecal material in pools comes from swimmers not showering before getting into the water, and from incidents of defecation in pools, according to the report. The average person has 0.14 grams of fecal material on their “perianal surface” that can rinse into a pool if a person doesn't shower first, according to the report. The Pseudomonas aeruginosabacteria in the pools may have come from the natural environment, or from swimmers, the researchers said. There were no samples that showed E. coli O157:H7, a toxin-producing E. coli strain that causes illness. Two parasites, Cryptosporidium and Giardia, which also spread through feces and cause diarrhea, were found in less than 2 percent of samples. The study included 161 pools in the Atlanta area, and the researchers noted their findings may not apply to all pools, but said there is no reason to think that contamination or swimmer hygiene practices differ between pools in the study and those in the rest of the country. The researchers collected samples of water from the pools' filters, and looked for the genetic material of specific bacteria. “Chlorine and other disinfectants dont kill germs instantly,” said Michele Hlavsa, chief of CDCs Healthy Swimming Program. Its important that swimmers shower before getting in a pool, not swallow the water they swim in, and avoid swimming when they have diarrhea, she said. The CDC also recommends that parents of young children take children on a bathroom break every hour, or check diapers every 30 to 60 minutes. Diapers should be changed in a diaper-changing area, not near the poolside, the CDC says. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/05/16/poop-prevalent-in-public-pools-cdc-says/

Potential treatment for Parkinson’s, Alzheimer’s, dementia discovered

A drug currently being used to treat leukemia has been found to help halt the production of toxic proteins in the brain linked to Alzheimer’s disease, Parkinson’s disease and various forms of dementia. Researchers from Georgetown University successfully used small doses of the drug nilotinib, used to treat chronic myelogenous leukemia (CML), to eliminate abnormal protein build-up in the brains of mice. The scientists targeted the alpha-Synuclein and tau proteins, which have been previously implicated in the development of Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), Huntington’s disease, Lewy body dementia and other neurodegenerative conditions. …