Tag Archives: protein

Breakthrough discovery into the regulation of a key cancer drug target

Scientists used a powerful technique called protein crystallography to look at 3D structures of protein complexes purified from cultured human cells. They discovered that a family of complexes, that switch off gene expression, is regulated by small signalling molecules called inositol phosphates. This latest study shows that this mode of regulation is conserved from yeast right through to man and is a fundamental process for life…

New understanding of why anti-cancer therapy stops working at a specific stage

The problematic therapy investigated involves suppression of the protein mTOR (mammalian target Of Rapamycin). MTOR plays an important role in regulating how cells process molecular signals from their environment, and it is observed as strongly activated in many solid cancers…

New study on popular prostate cancer protein provides insight into disease progression

Researchers have long understood the function of the protein, Caveolin-1 (Cav-1), in prostate cancer, including its role in treatment resistance and disease aggressiveness. However, prior to this study, little was known about the role of Cav-1 within the stroma. The study, published in the Journal of Pathology, found that a decreased level of the Cav-1 protein in the stroma indicated tumor progression — a function opposite to the known role of Cav-1 within a tumor…

7 ways to avoid the worst summer calorie bombs

It's officially the season of flip flops, swimsuits, and lots of summer traditions that revolve around…food! From going out for ice cream to munching on popcorn while taking in a blockbuster film, the weeks between now and Labor Day can present some major nutritional hurdles. Here's how to sidestep seven classic calorie bombs, and seriously upgrade your health. Trade ice cream for frozen treats Many of my clients crack open a pint of ice cream, with every intention of stopping at one serving, only to wind up polishing off the whole thing. Switching to frozen yogurt shaves off some calories, but a pint can still cost you 800, twice as much as a slice of cheesecake. The swap: Nix store bought pints, and make your own novelty treats. Whip up a smoothie in the blender, pour it into popsicle molds and freeze. One cup of unsweetened almond milk, combined with one cup of frozen pitted cherries and one tablespoon each almond butter and dark chocolate chips will make four to six pops for just 280 total calories. Or whip up a batch of frozen bananas—dip mini naners into organic nonfat Greek yogurt seasoned with cinnamon or vanilla (or a plant-based alternative like coconut milk yogurt), sprinkle with oats and nuts, wrap in wax paper, and freeze. Health.com: Supercool Low-Cal Frozen Treats Lighten up your umbrella drinks A piña colada is the quintessential summer cocktail, but a 12-ounce portion packs 600 calories, the amount in an entire six pack of light beer. The swap: Rather than giving up those fun frou frou drinks, whip up your own tropical concoction. Combine a shot of rum with 4 ounces of 100 percent pineapple juice, a quarter cup of frozen banana slices, a quarter cup of unsweetened coconut milk, and a handful of ice. A refreshing, and much slimmer substitute, at just 175 calories. Reassess your sushi Old school sushi rolls, made with steamed rice, lean seafood, and veggies provide about 200 calories each, but many “new wave” sushis are loaded with creamy sauces, fatty meats, fried ingredients, and cream cheese, which can tack on at least a few hundred more. A dragon roll, for example, can pack 500 calories, more than a quarter pound burger. The swap: Ditch the white rice, which is soaked in water with sugar to make it sticky, and order appetizers and side dishes. All together, seared tuna, edamame and seaweed salad add up to less than 350 calories. Health.com: How to Order Healthy Asian Takeout Rethink your thirst quenchers There's nothing like a tall glass of ice cold lemonade on a hot summer day, but most are made from water, sweetener, and lemon flavoring (not fresh fruit), and a lot more sugar than you might think. Sixteen ounces of standard lemonade contains the equivalent of fourteen cubes of sugar, about same amount as soda, with absolutely zero vitamin C. The swap: Make your own. Just a quarter cup of fresh squeezed lemon juice provides over 50 percent of your daily vitamin C needs, a nutrient linked in research to less body fat and smaller waist measurements. For extra flavor, aroma, color, and an antioxidant boost, add sprigs of fresh mint. And if you need a little sweetener, add a splash of a pure fruit juice, rather than sugar. At just 40 calories per quarter cup, 100 percent white grape juice is a good option, but mashing a little fresh fruit in the bottom of the pitcher, like juicy strawberries (6 calories each), will also do the trick. Order your movie popcorn naked I absolutely cannot go to the movies and not get popcorn; it's one of my totally worth it splurges. Fortunately popcorn itself is actually a member of the whole grain family, an important food group most Americans fall short on, that's linked to a lower risk of heart disease, type 2 diabetes, cancer, and obesity. And because “popped corn” is fluffy, it's far lower in carbs than dense pretzels, chips, nachos, or candy. The secret to keeping it light is passing on the buttery topping. The swap: In this case, it's more of a strategy than a swap. A small order can contain 225-400 calories, but going bare (sans butter), saves 130 calories per tablespoon (about the size of your thumb, from where it bends to the tip). Health.com: Best and Worst Movie Foods Remodel your munchies Chips and dip are staples at summer get-togethers, but they're a real recipe for waistline disaster. A handful of potato chips and a golf ball sized portion of French onion dip add up to 375 calories, about as much as a medium order of fast food fries. The swap: Upgrade to hummus and veggies, and instead of pre-packaged, blend your own batch. A serving made from a half cup chickpeas, a half teaspoon of minced garlic, and tablespoon each of water, fresh squeezed lemon and extra virgin olive oil, provides less than 250 calories, but is packed with 6 grams of satisfying protein, 7 grams of filling fiber, good-for-you fat, and a spectrum of antioxidants. Scoop it up with low cal, nutrient-rich veggies, like fresh broccoli florets, grape tomatoes, and sliced cucumber. Deflate your buns Whether you grill up turkey, salmon, or black bean burgers, one of the savviest ways to slash excess calories is to get rid of the bun, especially if you'll be indulging in any other starchy sides, like potato salad. You probably won't miss it (I've never had a client who included hamburger buns on his or her can't-live-without food list), and replacing it can instantly save you 150-300 calories. The swap: Seventy five percent of Americans fail to fit in the recommended minimum three daily veggie servings, and one of the best ways to fill the gap is to wrap your protein of choice in either crisp lettuce leaves, or two grilled Portobello mushroom caps. The latter provide just 30 calories each, along with fiber, plenty of antioxidants, vitamin D, and a little bonus protein. Outer leaves of romaine, or bibb lettuce are virtually calorie free, and great sources of immune-supporting vitamin A. And while veggies may be a little messier than a bun, the nutritional trade offs are well worth the extra effort! Cynthia Sass is a registered dietitian with master's degrees in both nutrition science and public health. Frequently seen on national TV, she's Health's contributing nutrition editor, and privately counsels clients in New York, Los Angeles, and long distance. Cynthia is currently the sports nutrition consultant to the New York Rangers NHL team and the Tampa Bay Rays MLB team, and is board certified as a specialist in sports dietetics. Her latest New York Times best seller is S.A.S.S! Yourself Slim: Conquer Cravings, Drop Pounds and Lose Inches. This article originally appeared on Health.com.source : http://www.foxnews.com/health/2013/06/04/7-ways-to-avoid-worst-summer-calorie-bombs/

Toxic waste from Greek yogurt poses danger to waterways

Greek yogurt has become an increasingly popular low-calorie treat in the United States, as it is thicker and contains more protein than regular yogurt.  In fact, the yogurt is in such high demand that total yogurt production has nearly tripled in New York state over the last five years. But the new diet fad harbors a dark secret. When Greek yogurt is strained, a thin, runny waste product known as acid (sour) whey is left over.  According to a new report from Modern Farmer, whey acid – a liquid containing mostly water, lactose (sugar), protein and yogurt cultures – is extremely toxic to the environment, making it illegal to dump.  The substance is so detrimental to the environment that if it enters nearby streams and rivers, it robs the water of so much oxygen that fish and other aquatic life start to die off over potentially large areas. The Modern Farmer report stated that for every 3 to 4 ounces of milk used, Chobani and other manufacturers can only make 1 ounce of Greek yogurt – the rest becoming acid whey.  Chobani is so desperate to get rid of the whey, the report maintained, they pay nearby farmers to haul the whey somewhere else.  They claim that 70 percent of their excess whey winds up in livestock feed. But the yogurt industry has remained relatively secretive on the issue, as there are currently no industry-wide statistics regarding where all of this excess whey is going.. Fortunately, the Modern Farmer report noted a possible consumer of excess whey: babies.  Dave Barbano, a dairy scientist at Cornell University, believes that the tiny amount of protein left over in acid whey could be used in infant formula.  Cheese manufacturers have managed to sell similar products from sweet whey, a byproduct of cheese. Whey protein is sold as an ingredient in body building supplements and in other foodstuffs – and Greek yogurt manufacturers are eager to try the same tactics. “There are a lot of people coming in and out of New York state looking at whether this is a good opportunity for investment,” Barbano told Modern Farmer. Other researchers at the Center for Dairy Research at the University of Wisconsin, Madison, are trying to figure out a way to extract the sugar from acid whey, which could be used as an ingredient in things like icing and bread.  And a farm in Scipio Center, N.Y., is hoping to convert the whey’s lactose into methane – which could ultimately be used to generate electricity. No matter what, the Modern Farmer report maintained that a solution needs to be found as soon as possible, because the development of excess whey isn’t slowing down. Click for more from Modern Farmer.source : http://www.foxnews.com/health/2013/05/29/toxic-waste-from-greek-yogurt-poses-danger-to-waterways/

Novel class of drugs for prostate cancers

In men with advanced prostate cancer, growth of cancer cells depends on androgen receptor signaling, which is driven by androgens, such as testosterone. To thwart tumor growth, most patients with advanced prostate cancer receive drugs that block the production of androgen or block the receptor where the androgen binds. Unfortunately, such treatments invariably fail and patients die of prostate cancer with their androgen receptor signaling still active and still promoting tumor growth. In the new study, available online at Nature Communications, a team of researchers led by Dr. …

Foods that trigger headaches

For many headache and migraine sufferers, certain foods can act as triggers. We received this question from a viewer: Dear Dr. Manny, I've noticed that whenever I eat red grapes I get a headache. Could there be something in them that is causing this to happen? Thanks, Jay Alvarez said grapes are low in calories and rich in vitamin C and fiber, so they are a nutritional snack. But they also contain a substance called tyramine, a naturally occurring amino acid that forms from the breakdown of protein in food as it ages. Tyramine can cause your blood pressure to rise, which can trigger headaches in some people. If you experience this reaction, you may want to avoid other trigger foods, such as: • Smoked or cured meats • Aged cheeses • Citrus fruits • Sauerkraut • Soy sauce • Red wine • And certain beers Research shows that tyramine in grapes can have a negative effect on certain antidepressants called MAOIs.  Patients taking these medications should talk to their doctor about their diet. Keeping a food diary to see if you may be sensitive to tyramine-rich foods could also help. The bottom line: Learn what your triggers are – so that you can avoid them. If you have a question, email DrManny@foxnews.com.source : http://www.foxnews.com/health/2012/10/03/foods-that-trigger-headaches/

Key find for early bladder cancer treatment

"With better knowledge of this protein, we can better determine a patient’s prognosis and see who needs more aggressive treatment immediately and who can be given a milder treatment without a risk to their life. We can see at an early stage which patients are in the risk zone for cancer recurrence," said Karolina Boman, a doctoral student at the Division of Pathology at Lund University…