Tag Archives: professor

Cancer study maps decade of discovery to potential anticancer agent — ScienceDaily

“What began with the question ‘what makes a particular aggressive form of breast cancer cells keep growing?’ turned into 10 years of systematic research to identify the enzyme PLK4 as a promising therapeutic target and develop a small molecule inhibitor to block it,” says Dr. Mak, Director of The Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre, University Health Network. …

How tumors remodel their surroundings to grow: New study provides insight — ScienceDaily

The findings, published July 3 in Cancer Cell, contribute to the increasing acknowledgement that the cells and tissue surrounding a tumor — the stroma — are an integral part of cancer initiation, growth, and expansion. “Our study reveals a precise mechanism that stromal cells use to encourage the tumorigenesis of epithelial cancer cells,” said Jorge Moscat, Ph.D., director of the Cell Death and Survival Networks Program at Sanford-Burnham. “We have shown that in the stroma, p62 acts as an anti-inflammatory tumor suppressor, controlling the inflammatory environment and the signals that promote cancer…

Cancer: Treatment that prevents tumor metastasis identified in animal study

The work by Professor Pierre Sonveaux’s team, at Université catholique de Louvain’s Institute of Experimental and Clinical Research (IREC), succeeded in pinpointing a family of pharmaceutical compounds whose action prevents the appearance of tumor metastasis. The researchers achieved this tour de force by studying the mitochondria in tumor cells. These organelles are considered as the cells’ power station…

Metastatic brain tumor treatment could be on the horizon with use of SapC-DOPS

However, a new Cincinnati Cancer Center (CCC) study, published in the advance online edition of the journal Oncotarget, provides hope that previously studied SapC-DOPS could be used for treatment of brain cancer that has spread. Xiaoyang Qi, PhD, member of the CCC, associate director and associate professor in the division of hematology oncology at the University of Cincinnati (UC) College of Medicine and a member of the UC Cancer and Neuroscience Institutes and the Brain Tumor Center, says this critical data shows promise for finding treatment for one of the deadliest cancers…