“A comprehensive geriatric assessment of elderly patients who are being evaluated for the Whipple procedure is essential,” said lead study author Dominic Sanford, MD, MPHS, a general surgery resident at the Washington University School of Medicine, St. …
The findings are particularly important for men with longer life expectancies because the therapy exposes them to more adverse side effects, and it is associated with increased risk of death and deprives men of the opportunity for a cure by other methods. The research study has been published online in European Urology.� The focus of the new study is androgen deprivation therapy (ADT), in which an injectable or implanted medication is used to disrupt the body’s ability to make testosterone. ADT is known to have significant side effects such as heart disease, diabetes, increased weight gain and impotence; however a growing body of evidence suggests ADT may in fact lead to earlier death…
Published online Dec. 5 in PLOS ONE, the scientists say the agent, YK-4-279, is the first drug targeted at the chromosomal translocations found in about half of prostate cancer cells. These translocations occur when two normal genes break off from a chromosome and fuse together in a new location. …
The results of their study appear online in the journal Nature today. “Treatment for advanced bladder cancer is limited to surgery and chemotherapy…
Q: How was the study set up and what factors were examined? …
Traditionally used to detect cancer, PET imaging shows how organs and tissues are functioning. When used with X-rays generated from CT scans, PET scans provide a more complete picture of the area of the body being examined…
The numbers add up to a strong economic case to invest in services to support mums to carry on breastfeeding, they conclude. In common with many other high income countries, breastfeeding rates in the UK are low, and to find out if boosting these could cut healthcare costs by improving mother and child health, the researchers focused on five priority diseases…
Bladder cancer is the ninth most common cancer in the world, with 430,000 new cases diagnosed in 2012. Europe and North America have the highest incidence of bladder cancer, with an even higher incidence in people with diabetes. Bladder tumours overexpress a natural part of the cell machinery, a transcription factor in the cell nucleus known as ‘peroxisome proliferator-activated receptor gamma’ (or PPARγ) that is found in the urothelium (the lining of the urinary tract). Both pioglitazone and rosiglitazone are part of the thiazolidinediones (TZDs) class of drugs, which act as PPARγ agonists, meaning they induce the same action as PPARγ…
Bladder cancer is the ninth most common cancer in the world, with 430,000 new cases diagnosed in 2012. Europe and North America have the highest incidence of bladder cancer, with an even higher incidence in people with diabetes…
Smoking is a risk factor for various diseases, not only lung cancer. Epidemiological data show that male smokers have a greater risk of developing cancer outside the respiratory tract than female smokers. In the present study, which is the result of an international collaboration, the researchers discovered an association between smoking and genetic damage among men that might explain this sex difference. ‘We have previously in 2014 demonstrated an association between loss of the Y chromosome in blood and greater risk for cancer…