Researchers sequence non-infiltrating bladder cancer exome — ScienceDaily
source : http://www.sciencedaily.com/releases/2013/10/131013163625.htm
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Genetic alterations show promise in diagnosis, treatment of bladder cancer — ScienceDaily
source : http://www.sciencedaily.com/releases/2013/10/131016100428.htm
Study expands cancer genomics universe — ScienceDaily
source : http://www.sciencedaily.com/releases/2014/01/140124115752.htm
Study expands cancer genomics universe
"For the first time, we know what it will take to draw the complete genomic picture of human cancer," said Broad Institute founding director Eric Lander, a senior co-author of the paper. "That’s tremendously exciting, because the knowledge of genes and their pathways will highlight new, potential drug targets and help lead the way to effective combination therapy." Over the past 30 years, scientists had found evidence for about 135 genes that play causal roles in one or more of the 21 tumor types analyzed in the study. The new report not only confirms these genes, but, in one fell swoop, increases the catalog of cancer genes by one-quarter. It uncovers 33 genes with biological roles in cell death, cell growth, genome stability, immune evasion, as well as other processes…
Biomarkers in blood show potential as early detection method of pancreatic cancer
MicroRNAs regulate gene expression and play important roles in the development of tumors and tumor metastasis. MicroRNA panels are a combination of several microRNAs. …
Fresh faced: Looking younger for longer
Publishing in The FASEB Journal, the authors describe how in laboratory tests, they compared the protection offered against either UVA radiation or free radical stress by several antioxidants, some of which are found in foods or cosmetics. While UVB radiation easily causes sunburn, UVA radiation penetrates deeper, damaging our DNA by generating free radicals which degrades the collagen that gives skin its elastic quality…
AML score combining genetic, epigenetic changes might help guide therapy
The findings, published in the Journal of Clinical Oncology, come from a study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James)…
Research into fruit fly cells could lead to cancer insights
The study, published today in Developmental Cell, describes a number of routes to the formation of a microtubule spindle — the tracks along which DNA moves when a cell divides in order to make two genetically identical cells. In order to understand the phenomenon, the authors, including Biosciences researchers Dr…
New data for engineering immune cells shows promise in solid tumors
Chimeric antigen receptor T cells (CAR T cells) are a form of personalized cell therapy that uses immune cells called T cells from patients. After T cells are harvested from a patient, they are engineered to bear a molecule that allows them to attach to a specific protein carried by the patient’s cancer cells and to be triggered to kill the cancer cells when they do so. …
Research backs risk-reduction surgery for ovarian cancer
The researchers from The University of Manchester — part of Manchester Cancer Research Centre — looked at 691 women who had undergone genetic testing and were confirmed as carrying a mutation in either the BRCA1 or BRCA2 gene before they had developed cancer. The study, funded by Genesis Breast Cancer Prevention, the UK’s only charity entirely dedicated to the prediction and prevention of breast cancer. The results were published recently in Breast Cancer Research and Treatment…