Tag Archives: models

Genetic testing could improve breast cancer prevention — ScienceDaily

Their study showed that prevention strategies could be improved by testing not only as currently for major cancer predisposition genes such as BRCA1 and BRCA2 — which identify a small percentage of women at very high risk — but also by factoring in data on multiple gene variants that individually have only a small effect on risk, but are more common in the population. The research was carried out by researchers at The Institute of Cancer Research, London, and the National Cancer Institute in Bethesda, US — and is published in the Journal of the National Cancer Institute. The study received funding from The Institute of Cancer Research (ICR), Breakthrough Breast Cancer and the National Cancer Institute. Researchers stressed that their study was a computer modelling analysis and would need to be confirmed by further research aimed at validating the models they used and assessing real-life prevention approaches…

Discovery about wound healing key to understanding cell movement

Professor Wayne Brodland is developing computational models for studying the mechanical interactions between cells. In this project, he worked with a team of international researchers who found that the way wounds knit together is more complex than we thought…

Metastatic brain tumor treatment could be on the horizon with use of SapC-DOPS — ScienceDaily

However, a new Cincinnati Cancer Center (CCC) study, published in the advance online edition of the journal Oncotarget, provides hope that previously studied SapC-DOPS could be used for treatment of brain cancer that has spread. Xiaoyang Qi, PhD, member of the CCC, associate director and associate professor in the division of hematology oncology at the University of Cincinnati (UC) College of Medicine and a member of the UC Cancer and Neuroscience Institutes and the Brain Tumor Center, says this critical data shows promise for finding treatment for one of the deadliest cancers. A lysosomal protein saposin C (SapC), and a phospholipid, known as dioleoylphosphatidylserine (DOPS), can be combined and assembled into tiny cavities, or nanovesicles, to target and kill many forms of cancer cells…

Metastatic brain tumor treatment could be on the horizon with use of SapC-DOPS

Clutter cutter: Computer modeling used to understand how messy cells contribute to cancer — ScienceDaily

source : http://www.sciencedaily.com/releases/2014/02/140219173144.htm

Using computer models to predict more effective therapies for colon tumors

In most tumors, the communication between the individual cells is disturbed and the cells permanently receive growth and survival signals. For this reason, drugs are increasingly used in modern tumor therapy that targets those molecules to shut down these faulty signals. Hitherto, however, it has been difficult to predict the success of such a therapy, since the signal molecules are integrated into an extremely complex cellular network, which, moreover, reacts differently for each patient, depending on the mutations the tumor bears. The research group headed by Nils Blüthgen, Charité Institute of Pathology, has now examined how the interconnection of such a cellular network affects the effectiveness of a therapy…

How to exercise without eating more

Maintaining that delicate balance of eating enough to fuel your workouts and not overdoing it afterwards is a source of confusion for even the most educated exerciser. Sometimes, those post-workout hunger pangs hit, begging you to replace what you just burned off. Other times, your brain is telling you it's time to reward your hard work (with extra cheese). Related:&#160;Foods That Will Make You Look Younger Recent research from Australia has reopened the debate on this quandary: Is it possible to exercise and not eat more? While findings have been mixed, a review of studies published in the journal Appetite showed that exercise does not, in fact, lead to a significant increase in calorie consumption. Related: Stylish Male Athletes Who Became Models And calories might not matter much anyway, according to Equinox tier 4 coach Dr. Paul Spector.&#160; “The goal of someone who says they want to lose weight is really to lose fat and gain muscle,” Spector said. “Therefore the real question with regard to exercise and nutrition is how to maximize the use of fat as a fuel source. It's about body composition, not weight.” More: The Worst Celebrity Eyebrows of All Time Want to train your body to burn more fat?