Groundbreaking discovery in deadly childhood cancer
"We undertook this study because we wanted to learn what was driving the growth of these tumors and how best to treat them," says the study’s co-principal investigator, Dr. …
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Game-changing shift occurring in cancer discovery, treatment
Clinical Cancer Advances 2013: ASCO’s Annual Report on Progress Against Cancer reveals how marked expansion in our knowledge and understanding of cancer is already improving treatment while also pointing the way towards even more effective approaches in the future. Published today in the Journal of Clinical Oncology, the ASCO report covers a broad range of cancer types and highlights a selection of the most recent achievements across the entire continuum of cancer care, from prevention and screening to treatment and survivorship. "For patients today, these results can be critical. Scientifically, they demonstrate how our long term investment in science and technology can yield practical advances now and in the near future," said ASCO President Clifford A…
Fight against cancer: The anti-tumor activity of immune cells can be restored
Max Mazzone: "For many years the biological processes which lead to the coordinated navigation of blood vessels and nerves have been studied. …
New strain of bird flu packs a punch even after becoming drug-resistant
It is not uncommon for influenza viruses to develop genetic mutations that make them less susceptible to anti-flu drugs. However, these mutations usually come at a cost to the virus, weakening its ability to replicate and to spread from one person to another…
Common outcome measures required for neurofibromatosis clinical trials
The (REiNS) Collaboration was formed to achieve consensus regarding the design of clinical trials for treatments of NF and related disorders, with a focus on developing a standard set of appropriate and meaningful outcome measures. "This supplement presents the initial progress of several of the working groups and includes the first series of consensus recommendations for NF clinical trial endpoints by the REiNS International Collaboration," according to an introduction by Dr Scott R. …
Novel cancer cell DNA damage repair mechanism unveiled
The new findings explain partially why cancer cells, unlike normal cells, fail to die as a result of DNA damaging insults, and how this mechanism causes new genetic mutations in cancer cells. This new information directly benefits cancer research. Now that scientists understand the repair mechanism, they are better equipped to develop drug therapies that specifically target cancerous cells. …
Ultrasound microscopy: Aid for surgeons to make the invisible, visible
Ultrasonic microscopes have a wide range of applications including determining the presence of otherwise invisible defects in components used in the automobile, aeronautical, and construction industries. Professor Naohiro Hozumi of Toyohashi Tech’s Department of Electrical and Electronic Information Engineering is developing the technology to monitor living tissue and cell specimens for medical purposes. …
Gene sequencing project finds drugs with promise for treating childhood tumor
Oxidative stress is caused when oxygen-free radicals and other byproducts of cell metabolism build up in cells. …
Biomarker linked to aggressive breast cancers, poor outcomes in African-Americans
"Our data indicate that HSET represents a potential new biomarker for poor breast cancer outcome among African-American women with the disease," said Ritu Aneja, Ph.D., associate professor in the Department of Biology at Georgia State University in Atlanta. "Using this biomarker effectively could give oncologists critical new information and potentially save lives by allowing earlier recognition of more aggressive breast cancers in African-American women, with the subsequent use of more customized treatment regimens to better manage disease." African-American women are often diagnosed with breast cancer at a younger age than non-Hispanic white women and are more likely to have cancers that spread, recur, or result in death. Identification of biomarkers that can help clinicians predict if African-American women will have aggressive cancer is a high priority, according to Aneja. …
Results from first 59 leukemia patients who received investigational, personalized cellular therapy
Two of the first three chronic lymphocytic leukemia (CLL) patients who participated in the study, which started in the summer of 2010, remain in remission, with tests revealing reprogrammed cells still circulating in their bodies, on guard to combat tumor cells that may reappear in the future. Additional highlights of the new research results include an 89 percent complete response rate among adult and pediatric patients with acute lymphoblastic leukemia (ALL). "In a very short time, we’ve learned so much about how CTL019 works and how powerful it can be," said the research team’s leader, Carl H…