Tag Archives: journal

Bone drug should be seen in a new light for its anti-cancer properties — ScienceDaily

Several clinical trials – where women with breast cancer were given these drugs (bisphosphonates) alongside normal treatment for early-stage disease – showed that they can confer a ‘survival advantage’ and inhibit cancer spread in some women, although until now no-one has understood why. A new study by Professor Mike Rogers, Dr Tri Phan and Dr Simon Junankar from Sydney’s Garvan Institute of Medical Research has used sophisticated imaging technologies to reveal that bisphosphonates attach to tiny calcifications in tumours in mice. These calcium-drug complexes are then devoured by ‘macrophages’, immune cells that the cancer hijacks early in its development to conceal its existence. The study, which includes remarkable movies of the entire process described above, is published in the journal Cancer Discovery, now online…

Bone drug should be seen in a new light for its anti-cancer properties

Several clinical trials – where women with breast cancer were given these drugs (bisphosphonates) alongside normal treatment for early-stage disease – showed that they can confer a ‘survival advantage’ and inhibit cancer spread in some women, although until now no-one has understood why. …

CT lung screening appears cost-effective

“This provides evidence, given the assumptions we used, that it is cost-effective,” said Ilana Gareen, assistant professor (research) of epidemiology in Brown University’s School of Public Health and second author on the new study in the New England Journal of Medicine. Four years ago, the vast NLST showed that low-dose helical CT scanning reduced mortality from lung cancer by 20 percent compared to chest X-rays. The study involved more than 53,000 smokers aged 55-74…

Report card on complementary therapies for breast cancer

Meditation, yoga, and relaxation with imagery were found to have the strongest evidence supporting their use. They received an “A” grade and are recommended for routine use for anxiety and other mood disorders common to breast cancer patients. The same practices received a “B” grade for reducing stress, depression, and fatigue, but are also endorsed for most breast cancer patients…

‘Treasure in saliva’ may reveal deadly diseases early enough to treat them

The study, the most comprehensive analysis ever conducted of RNA molecules in human saliva, reveals that saliva contains many of the same disease-revealing molecules that are contained in blood. It was published online today by the peer-reviewed journal Clinical Chemistry and will be published in the journal’s January 2015 special print issue, “Molecular Diagnostics: A Revolution in Progress.” “If we can define the boundaries of molecular targets in saliva, then we can ask what the constituents in saliva are that can mark someone who has pre-diabetes or the early stages of oral cancer or pancreatic cancer — and we can utilize this knowledge for personalized medicine,” said Dr…

Different brain tumors have the same origin, new findings show

The most common primary, malignant brain tumors in adults, called glioma, are formed from cells in the brain that are not nerve cells. These are serious tumors that lack efficient treatment and relapses are common. There are different types of glioma, classified according to an established system based on which cell type the tumor arises from. The most common gliomas are astrocytoma, which have their name from astrocytes, and oligodendroglioma, which are believed to arise from oligodendrocytes. …

Decades of research: Effectiveness of phone counseling for cancer patients still unknown

“The answer is that we really don’t know yet,” says Sonia Okuyama, MD, investigator at the CU Cancer Center and the paper’s first author. The small sample sizes of most studies, focus on non-Hispanic white patients (predominantly in breast cancer), varied design of the phone interventions offered, and lack of consistency in adhering to reporting guidelines means that despite a high number of published studies, few definitive findings are possible…