A summary of their findings will be published the week of July 28 in the Proceedings of the National Academy of Sciences. Low levels of oxygen stimulate the production and activation of HIF-1alpha, which protects cells in two ways…
In their study described in the June 18 issue of Cancer Immunology Research, the Johns Hopkins team tested the vaccine in 39 people with pancreatic ductal adenocarcinomas (PDAC), the most common form of pancreatic cancer. The disease becomes resistant to standard chemotherapies and is particularly lethal, with fewer than 5 percent of patients surviving five years after their diagnosis. PDACs do not typically trigger an immune response against the cancer cells that comprise, but with the help of a vaccine developed by Johns Hopkins researcher Elizabeth Jaffee, M.D., the scientists were able to “reprogram” tumors to include cancer-fighting immune system T cells…
source : http://www.sciencedaily.com/releases/2014/05/140512214128.htm
source : http://www.sciencedaily.com/releases/2014/04/140418083335.htm
source : http://www.sciencedaily.com/releases/2014/03/140326141650.htm
source : http://www.sciencedaily.com/releases/2014/02/140225122227.htm
source : http://www.sciencedaily.com/releases/2014/01/140123221915.htm
"Metastasis is what most threatens breast cancer patients, and we have found a way to stop the first part of the process in mice," says Andrew Ewald, Ph.D., assistant professor of cell biology at the Johns Hopkins School of Medicine. Before metastasis occurs, single cells on the edge of a tumor, termed leader cells, form protrusions into the surrounding tissue, like someone dipping a toe in to test the water before deciding to venture farther, Ewald says. If the conditions are right, the leader cells act as guides, with many tumor cells following behind, as they escape the confines of the tumor into the healthy tissue beyond. Full metastasis occurs when the cells succeed in migrating to a new location — the lungs, for example — and set up shop, creating a new tumor…
In a study published this week in Preventive Medicine, researchers from San Diego State University, the Santa Fe Institute, the University of North Carolina and the Johns Hopkins Bloomberg School of Public Health found that when celebrities publicly discuss their struggles with cancer diagnoses, the resulting media coverage prompts more smokers to search for information on quitting than events like New Year’s Day or World No Tobacco Day. Public health experts have long known these discussions spur others to get screened for cancer or consider the same treatments, but it was unclear whether these discussions also promoted cancer prevention behaviors, like quitting smoking. This question has evaded study because the method most commonly used to assess cancer-related behaviors — annual telephone surveys — isn’t fine-grained enough to tell researchers which events are influencing respondents’ answers. …
A report on the discovery, published in the Dec. 5 issue of Science, also suggests that a normal immune system is critical for preventing the development of common types of cancer. According to researchers, patients with scleroderma often make immune proteins or antibodies to another protein, called RPC1. These antibodies are believed to cause the organ damage characteristic of the disease, and the reason behind this antibody production has remained unknown…