Tag Archives: breast

Scientists find potential new clues for identifying breast cancer risk

Dr. David Gilley’s laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves’ laboratory at the BC Cancer Agency’s Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells. …

New technology makes breast cancer surgery more precise

Surgeons at UC Irvine Medical Center are the first in the country to use a device that reduces by half the need to reoperate and cut out breast cancer cells missed during an initial lumpectomy. The MarginProbe System lets the surgeon immediately assess whether cancer cells remain on the margins of excised tissue. Currently, patients have to wait days for a pathologist to determine this…

GATA-3 is important for regulation and maintenance of immune system

GATA-3’s role in CD4 T-cells has been widely studied, but its role in CD8+ cells has received much less attention. "We want to know what the basic function of GATA-3 in regulating cell biology is, although it has been shown that GATA-3 is important for the function of CD4+ T cell type to clear extracellular parasites," said Yisong Wan, PhD, assistant professor of microbiology and immunology at the UNC School of Medicine and member of UNC Lineberger Comprehensive Cancer Center. The research, published online May 26 by Nature Immunology, shows that GATA-3 is required for the maintenance and function of CD8+ T-cells, a T-cell type mediating the immune response to clear pathogens, eradicate tumors and promote inflammation. …

Research identifies a way to make cancer cells more responsive to chemotherapy

Dr. Shawn Li, PhD, and his team at Western’s Schulich School of Medicine & Dentistry, identified that a protein called Numb functions to promote the death of cancer cells by binding to and stabilizing a tumor suppressor protein called p53 -a master regulator of cell death. The scientists found when Numb is reduced or methylated by an enzyme called Set8, it will no longer protect p53. …

Foster Farms recalls grilled chicken breast strips for containing allergens

SAN FRANCISCO – & California-based chicken producer Foster Farms is recalling about 6,165 pounds of its ready-to-eat grilled chicken breast strips because the strips contain wheat and soy -- known allergens -- which are not listed on the labels of its packages, federal agriculture officials said. The mislabeled packages were discovered when a customer complained, the U.S. Department of Agriculture's Food Safety and Inspection Service said in announcing the recall Tuesday. The problem occurred when labels for another chicken product that does not contain wheat or soy were inadvertently used, food safety inspectors and officials at Foster Farms said. There have been no reports of adverse reactions from the sale of the mislabeled products, officials said. The chicken breast strips being recalled were sold in 4.5-pound cases containing 12, 6-ounce trays of “Foster Farms Grilled Chicken Breast Strips Boneless & Skinless With Rib Meat 97% Fat Free,” with an identifying case code of “000606.” The recalled product bears the establishment number “P-20923” inside the USDA mark of inspection and a use-by date of “JUN 22 2013” printed on each tray. They were produced April 23 and were distributed to retailers in Arizona, California, Hawaii, Nevada, Oregon, Utah and Washington. Based in Porterville, Foster Farms is a family-owned company that has been operating since 1939, according to the company's website. In a statement, Fosters Farms spokeswoman Lorna Bush said “food safety is, and always has been, our top priority.”source : http://www.foxnews.com/health/2013/05/22/foster-farms-recalls-grilled-chicken-breast-strips-for-containing-allergens/

Despite new recommendations, women in 40s continue to get routine mammograms at same rate

In 2009, the U.S. Preventive Services Task Force (USPSTF) sifted through the evidence and recommended that while women ages 50-74 should continue to undergo mammograms every two years, those between the ages of 40 and 49 without a family history of breast cancer should discuss the risks and benefits of routine screening mammography with their physicians to make individual decisions. As a result of the altered recommendations, Lauren D. Block, M.D., M.P.H., a clinical fellow in the Division of General Internal Medicine at the Johns Hopkins University School of Medicine, and her colleagues expected to find fewer women in their 40s getting routine mammograms. …

New approaches give women more options for breast cancer surgery

CHICAGO – & Treating breast cancer almost always involves surgery, and for years the choice was just having the lump or the whole breast removed. Now, new approaches are dramatically changing the way these operations are done, giving women more options, faster treatment, smaller scars, fewer long-term side effects and better cosmetic results. It has led to a new specialty -- “oncoplastic” surgery -- combining oncology, which focuses on cancer treatment, and plastic surgery to restore appearance. “Cosmetics is very important” and can help a woman recover psychologically as well as physically, said Dr. Deanna Attai, a Burbank, Calif., surgeon who is on the board of directors of the American Society of Breast Surgeons. Its annual meeting in Chicago earlier this month featured many of these new approaches. More women are getting chemotherapy or hormone therapy before surgery to shrink large tumors enough to let them have a breast-conserving operation instead of a mastectomy. Fewer lymph nodes are being removed to check for cancer's spread, sparing women painful arm swelling for years afterward. Newer ways to rebuild breasts have made mastectomy a more appealing option for some women. More of them are getting immediate reconstruction with an implant at the same time the cancer is removed rather than several operations that have been standard for many years. Skin and nipples increasingly are being preserved for more natural results. Some doctors are experimenting with operating on breast tumors through incisions in the armpit to avoid breast scars. There's even a “Goldilocks” mastectomy for large-breasted women -- not too much or too little removed, and using excess skin to create a “just right” natural implant. Finally, doctors are testing a way to avoid surgery altogether, destroying small tumors by freezing them with a probe through the skin. “Breast surgery has become more minimalistic,” said Dr. Shawna Willey of Georgetown's Lombardi Comprehensive Cancer Center. “Women have more options. It's much more complex decision-making.” Breast cancer is the most common cancer in women around the world. In the U.S. alone, about 230,000 new cases are diagnosed each year. Most can be treated by just having the lump removed, but that requires radiation for weeks afterward to kill any stray cancer cells in the breast, plus frequent mammograms to watch for a recurrence. Many women don't want the worry or the radiation, and choose mastectomy even though they could have less drastic surgery. Mastectomy rates have been rising. Federal law requires insurers to cover reconstruction for mastectomy patients, and many of the improvements in surgery are aimed at making it less disfiguring. Here are some of the major trends: IMMEDIATE RECONSTRUCTION Doctors used to think it wasn't good to start reconstruction until cancer treatment had ended -- surgery, chemotherapy, radiation. Women would have a mastectomy, which usually involves taking the skin and the nipple along with all the breast tissue, followed by operations months later to rebuild the breast. Reconstruction can use tissue from the back or belly, or an implant. The first operation often is to place a tissue expander, a balloon-like device that's gradually inflated to stretch the remaining skin and make room for the implant. A few months later, a second surgery is done to remove the expander and place the implant. Once that heals, a third operation is done to make a new nipple, followed by tattooing to make an areola, the darkened ring around it. The new trend is immediate reconstruction, with the first steps started at the time of the mastectomy, either to place a tissue expander or an implant. In some cases, the whole thing can be done in one operation. Nationally, about 25 to 30 percent of women get immediate reconstruction. At the Mayo Clinic, about half do, and at Georgetown, it's about 80 percent. SPARING SKIN, NIPPLES Doctors usually take the skin when they do a mastectomy to make sure they leave no cancer behind. But in the last decade they increasingly have left the skin in certain women with favorable tumor characteristics. Attai compares it to removing the inside of an orange while leaving the peel intact. “We have learned over time that you can save skin” in many patients, Willey said. “Every single study has shown that it's safe.” Now they're going the next step: preserving the nipple, which is even more at risk of being involved in cancer than the skin is. Only about 5 percent of women get this now, but eligibility could be expanded if it proves safe. The breast surgery society has a registry on nipple-sparing mastectomies that will track such women for 10 years. “You really have to pick patients carefully,” because no one wants to compromise cancer control for cosmetic reasons, Attai said. “The preliminary data are that nipple-sparing is quite good,” but studies haven't been long enough to know for sure, Willey said. “It makes a huge difference in the cosmetic outcome. That makes the woman's breast recognizable to her.” Dr. Judy Boughey, a breast surgeon at the Mayo Clinic, said the new approach even has swayed patients' treatment choices. “We're seeing women choosing the more invasive surgery, choosing the mastectomy,” because of doctors' willingness to spare skin and nipples, she said. It helped persuade Rose Ragona, a 51-year-old operations supervisor at O'Hare Airport in Chicago. She had both breasts removed on April 19 with the most modern approach: Immediate reconstruction, with preservation of her skin and nipples. “To wake up and just see your breasts there helped me immensely,” she said. She chose to have both breasts removed to avoid radiation and future worry. “I felt it was a safer road to go,” she said. “I can't live the rest of my life in fear. Every time there's a lump I'm going to worry.” FREEZING TUMORS Attai, the California breast surgeon, is one of the researchers in a national study testing cryoablation. The technique uses a probe cooled with liquid nitrogen that turns tumors into ice balls of dead tissue that's gradually absorbed by the body. This has been done since 2004 for benign breast tumors and the clinical trial is aimed at seeing if it's safe for cancer treatment. “The technology is amazing. This is done in the office under local anesthesia, a little skin puncture,” Attai said. In the study, women still have surgery at some point after the freezing treatment to make sure all the cancer is destroyed. If it proves safe and effective, it could eliminate surgery for certain cancer patients. “I'd love to see the day when we can offer women with small breast tumors a completely non-operative approach, and I do think that's coming soon,” Attai said.source : http://www.foxnews.com/health/2013/05/14/new-approaches-give-women-more-options-for-breast-cancer-surgery/

Your immune system: On surveillance in the war against cancer

"We know that one function of our immune system is to detect and destroy pre-malignant cells before they can become cancer," said lead author Lance D. Miller, Ph.D., associate professor of cancer biology at Wake Forest Baptist. "However, sometimes the immune system becomes unresponsive to the presence of these cells and a tumor develops." This unresponsiveness can be temporary, and the immune system can remain alerted to the fact that there’s a problem. Immune cells can stand post along the borders of the tumor and even infiltrate the tumor core, where they may gain a better position for eventual attack. …

Popular diabetes drug does not improve survival rates after cancer

The study, published in the journal Diabetes Care, failed to show an improved survival rate in older breast cancer patients with diabetes taking the drug metformin, a first-line treatment for diabetes. However, the authors caution further research is necessary to validate the study’s findings. "Metformin is a drug commonly used by diabetic patients to control the amount of glucose in their blood," said the study’s lead author Dr. Iliana Lega, a research fellow at Women’s College Research Institute…