Tag Archives: amsterdam

Mesothelioma: New Findings On Treatment Options

“Mesothelioma remains a difficult disease to find better treatment options for, so we asked whether high-dose hemithoracic radiotherapy would decrease the rate or delay the time of local recurrence after chemotherapy and radical surgery,” says lead author Prof Rolf A. Stahel, from the Clinic and Policlinic for Oncology, at the University Hospital Zurich, Switzerland, and current President of the European Society for Medical Oncology. The multicentre trial included 153 patients with surgically-treatable malignant pleural mesothelioma, who were first treated with three chemotherapy cycles of cisplatin and pemetrexed, followed by surgical removal of affected lung tissue, with the goal of complete removal of the cancerous areas of lung. …

Some lung cancer patients could live longer when treated with new radiotherapy strategy

SCLC is an aggressive cancer that accounts for about 13% of all lung cancers. The majority of patients present with extensive disease that has spread to other areas of the body. “In recent years, we have made some progress in improving survival by giving prophylactic cranial radiotherapy (radiation to the head to reduce the risk of the cancer spreading to the brain) after chemotherapy, and this is now considered the standard of care. …

Lacking trust in one’s doctor affects health of emotionally vulnerable cancer patients

Patients who feel anxious and uneasy with their doctor may be impacted the most. “Anxiously attached patients may experience and report more physical and emotional problems when the relationship with their physician is perceived as less trusting,” said Chris Hinnen, Ph.D., lead author and clinical psychologist at Slotervaart Hospital in Amsterdam, The Netherlands. The researchers acknowledge that the issue of trust between patients and their doctors can be complicated, but observe that it’s important to understand fears of rejection and abandonment that often exist in anxiously attached patients. Hinnen and his colleagues analyzed questionnaire responses from 119 participants with breast, cervical, intestinal or prostate cancers at 3, 9 and 15 months after their diagnosis. …

Young patients with metastatic colorectal cancer at higher risk

That’s according to research presented to the 2013 European Cancer Congress in Amsterdam. The team of scientists is led by an investigator at University of Colorado Cancer Center. An analysis of 20,034 patients in 24 phase III clinical trials showed that the youngest and oldest patients had the highest risk of disease progression and death, compared to middle-aged patients…

First randomized trial of targeted cancer medicine in all tumor types

Dr Christophe Le Tourneau, Head of the Phase I Programme at the Institut Curie, Paris, France, will tell the congress that the SHIVA trial is the first randomised trial to look at patient outcomes after treatments were chosen according to the individual molecular profiles of each person’s tumour. It is also the first trial to do this for all tumour types. About 40% of all those taking part in the trial have molecular abnormalities that can be targeted by existing drugs, he will say…

Women willing to delay antibiotics for UTIs

More women than previously thought may be willing to delay taking antibiotics to treat a urinary tract infection in order to reduce the potentially unneeded use of antibiotics, a new Dutch study shows. More than one-third of women in the study with UTI symptoms said they were willing to wait a week to see if the infection would improve on its own before starting antibiotics. And more than 70 percent of the women who didn't use antibiotics for a week showed improvements or had their symptoms disappear completely, according to the study published May 30 in the journal BMC Family Practice. UTIs are more common in women than men, and are caused by E. coli bacteria in 80 to 90 percent of cases. The standard treatment for UTIs is a few days of antibiotic treatment, but the increasing emergence of antibiotic-resistant bacteria has become a serious concern, experts say. “To counteract this increasing resistance, the use of antibiotics should be limited in healthy patients who can also be cured without them,” study researcher Dr. Bart Knottnerus, from the University of Amsterdam said in an email. Studies show that when patients have UTI symptoms, most often, antibiotic treatment is started before the results of urine cultures, which look for the presence of bacteria, are known. “In fact, a culture is seldom done. Instead, the probability of a positive culture is estimated by asking questions and performing urine investigations,” Knottnerus said. “Since no test is perfect, some patients without UTI will get antibiotics, and some patients with UTI will not.” In the study, 137 patients were asked by their doctor to delay antibiotic treatment for one week. Fifty-one women were willing to wait. After one week, 28 of those women had still not used antibiotics and 20 of them reported clinical improvement. None of the participating women developed kidney infection, according to the study. Kidney infection is a serious condition that can occur if a UTI is left untreated, and needs a more aggressive antibiotic treatment. The researchers say that bladder infections seldom progress to the kidneys. “If a kidney infection occurs in a healthy woman, she can be cured by antibiotics,” Knottnerus said. “But to make sure that these antibiotics will still be effective in the future, it is important to limit their use in mild infections (like bladder infections).” It is important that women with UTI symptoms be monitored by a doctor if they choose to delay antibiotics. “If a woman gets ill (fever, shivering, flank pain), the infection may be progressing to the kidney,” Knottnerus said. Previous studies have shown that in somecases, patients recover from UTIs within a week without taking antibiotics. Knottnerus said the reason is that they either didn't have a UTI, or didn't need antibiotics to cure it. The body's defense mechanisms are often strong enough to fend off infections without any help from antibiotics, he said. Dr. Timothy Jenkins, assistant professor at the Division of Infectious Diseases, University of Colorado, said about the new study: “Progressive antibiotic resistance in bacteria is a major problem in the United States and worldwide, so it is very important that we develop novel strategies to reduce antibiotic use, such as the one proposed in this study.” Jenkins noted that antibiotic use in the Netherlands is extremely low, whereas antibiotic use in the United States is quite high. “Therefore, whether this study is applicable to women in the U.S. where the societal expectation for antibiotics is greater is not known,” he said. New guidelines published last week, from the Dutch College of General Practitioners, support the advice to delay antibiotic treatment for uncomplicated urinary tract infections, the researchers said. Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.source : http://www.foxnews.com/health/2013/06/04/women-willing-to-delay-antibiotics-for-utis/