The research, which has shown promise in clinical samples, has been published in the scientific journal, Cell Death and Disease. The group of scientists coordinated by Dr Salvador Macip from the Mechanisms of Cancer and aging Lab and the Department of Biochemistry of the University of Leicester carried out the study to find new ways of identifying old cells in the body…
The question becomes who is invading whom — do cancer cells invade the basement membrane or do some fibroblasts help invading cancers? Researchers at the Institut Curie in Paris now say that they have evidence of a coordinated attack on the basement membrane by cancer cells in situ and CAF cells in the extracellular matrix that begins long before the actual translocation of cancer cells. …
The findings — to be presented in poster form on December 6, from 5:30 PM to 7:30 PM, in the West Building, Level 1 — may ultimately guide doctors in deciding which therapies are best for individual patients with myeloma, the study authors say. The study focused on exosomes, tiny sacs that cells release into the bloodstream as a way of communicating with other cells. The exosomes contain microRNA molecules, fragments of RNA that help control the activity of genes…
The current study results revolve around proteinases, enzymes that break down proteins as part of cellular life. Matrix metalloproteinases or MMPs specifically target the extracellular matrix, the non-cell, structural framework within tissues. Beyond that role, the new study found that one member of this family, MMP-2, has another signaling role related to the human immune system. It may shift a set of cells to become part of immune response that accelerates healing in some cases, but may worsen inflammatory disease in others. …
The numbers add up to a strong economic case to invest in services to support mums to carry on breastfeeding, they conclude. In common with many other high income countries, breastfeeding rates in the UK are low, and to find out if boosting these could cut healthcare costs by improving mother and child health, the researchers focused on five priority diseases. They looked at the financial impact of not breastfeeding on gastrointestinal and lower respiratory tract infections; the ear infection otitis media in infants; the potentially lethal gut disorder necrotising enterocolitis in preterm babies; and lifetime risk of breast cancer in mothers…
“A comprehensive geriatric assessment of elderly patients who are being evaluated for the Whipple procedure is essential,” said lead study author Dominic Sanford, MD, MPHS, a general surgery resident at the Washington University School of Medicine, St. …
Published online Dec. 5 in PLOS ONE, the scientists say the agent, YK-4-279, is the first drug targeted at the chromosomal translocations found in about half of prostate cancer cells. These translocations occur when two normal genes break off from a chromosome and fuse together in a new location. …
The researchers study the development of T cells and B cells, which are lymphocytes (or immune cells) that play a central role in protecting our body against infections by viruses, bacteria and other microbial agents. “As these lymphocytes develop, they must learn how to recognize different pathogens in the body,” says Dr. M�r�y, Director of the Hematopoiesis and Cancer research unit at the IRCM. “Part of this process involves the breaking and rearranging of the genes responsible for producing the lymphocyte receptors that recognize these pathogens…
Q: How was the study set up and what factors were examined? …
The numbers add up to a strong economic case to invest in services to support mums to carry on breastfeeding, they conclude. In common with many other high income countries, breastfeeding rates in the UK are low, and to find out if boosting these could cut healthcare costs by improving mother and child health, the researchers focused on five priority diseases…