When cells are under duress, they curtail almost all protein synthesis and stash their mRNAs in stress granules. These structures help healthy cells, but they also allow tumor cells to survive harsh conditions. A protein named YB-1, which is overexpressed in many types of tumors, accumulates in stress granules, but researchers don’t know how YB-1… Read More »
While past studies have highlighted the relationship between better erectile function and exercise, African-American men have been underrepresented in this literature. “This study is the first to link the benefits of exercise in relation to improved erectile and sexual function in a racially diverse group of patients,” said Adriana Vidal, PhD, senior author of the… Read More »
The team, led by Thirumala-Devi Kanneganti, Ph.D., a member of the St. Jude Department of Immunology, found key receptors responsible for sensing DNA in cells infected by the tularemia-causing bacterium, Francisella. Tularemia is a highly infectious disease that kills more than 30 percent of those infected, if left untreated. It can be readily transmitted by… Read More »
Previous research by the study’s lead author Grace Lu-Yao, PhD, MPH, cancer epidemiologist at the Cancer Institute of New Jersey and professor of medicine at Rutgers Robert Wood Johnson Medical School, and colleagues examined 10-year outcomes for this population (JAMA, Vol. 302, No. 11). The 2009 research showed men diagnosed with prostate cancer beginning in… Read More »
B cells are white blood cells that produce antibodies against antigens, namely substances which the immune system recognises as foreign. Normal B cell development and maturation is regulated by a balance between kinase and phosphatase enzymes. These enzymes phosphorylate or de-phosphorylate the signalling subunits of the B cell antigen receptors (BCR). This means that the… Read More »
“What we have found is that Asian Americans are an incredibly diverse group that cannot be indiscriminately combined together,” said Trinh, associate surgeon for the Division of Urology at BWH, faculty at the Center for Surgery and Public Health (CSPH) and lead author of the study. “With Asian Americans, there is important variation in socioeconomic… Read More »
In recent years, there have been numerous reports in the media about potential risks of tests that use ionizing radiation. However, benefit-risk discussions about ionizing radiation from medical imaging are rare and seldom initiated by clinicians. For the new study, researchers from Memorial Sloan Kettering Cancer Center (MSKCC) in New York City analyzed over nine… Read More »
However, the mechanisms behind the protective effect have not been understood and it is not known why some people appear to benefit while others do not. Conducted by investigators from four countries, including Professors Mark Jenkins and John Hopper from the University of Melbourne, the findings suggest this protection differs according to variations in DNA.… Read More »
In a randomized phase 3 trial, adrenal cancer patients receiving the investigational drug linsitinib fared no better than patients receiving a placebo. But the researchers noticed a small subset of patients who had significant response and remained on the drug for an extended time. “While it was only a small subset of patients who responded to linsitinib, this remains very promising in the era of precision medicine,” says co-principle investigator Gary D. …
One of the challenges of personalised medicine is the development of treatment resistance. At the Comprehensive Cancer Center (CCC) Vienna at the MedUni Vienna and Vienna General Hospital, a study is now commencing which involves patients with metastasized bowel cancer who are undergoing a new diagnostic method, namely liquid biopsy in the form of a blood test. The aim of this new method is to spot a tumor’s development of resistance early on and therefore adjust the treatment quickly and in a targeted manner…