The study – funded by Cancer Research UK, Action Medical Research and others – shows that taking an extra tumour sample at recurrence, when there are no effective therapies, could identify subsets of patients that might be treatable with existing drugs that target the genetic faults. …
Airplane windshields are commonly made of polycarbonate plastic or multilayer composite glass. UV-A radiation can cause DNA damage in cells and its role in melanoma is well known, according to the article. Author Martina Sanlorenzo, M.D., of the University of California, San Francisco, and co-authors measured the amount of UV radiation in airplane cockpits during flights and compared them with measurements taken in tanning beds. The cockpit radiation was measured in the pilot seat of a general aviation turboprop airplane through the acrylic plastic windshield at ground level and at various heights above sea level…
“Using genetic deletion we found that SIRT1 normally restrains prostatic intraepithelial neoplasia in animals. …
The scientists say when activated, one protein, called the short form, stops glioblastoma cells from replicating their DNA, and the other, called the long form, prevents cell division if the DNA has already been replicated, explains Rebecca Riggins, PhD, assistant professor of oncology at Georgetown Lombardi. The study was posted online Dec. …
The new molecules — synthetic antibody mimics (SyAMs) — attach themselves simultaneously to disease cells and disease-fighting cells. The result is a highly targeted immune response, similar to the action of natural human antibodies. “Unlike antibodies, however, our molecules are synthetic organic compounds that are approximately one-twentieth the size of antibodies,” said David A. Spiegel, a professor of chemistry at Yale whose lab developed the molecules…
In a revolutionary approach the researchers from the Cancer Research UK Cambridge Institute made the discovery by combining images from cancer samples with genetic data. …
A gene normally involved in the regulation of embryonic development can trigger the transition of cells into more mobile types that can spread without regard for the normal biological controls that restrict metastasis, the new study shows. Analysis of downstream signaling pathways of this gene, called SNAIL, could be used to identify potential targets for scientists who are looking for ways to block or slow metastasis. “This gene relates directly to the mechanism that metastatic cancer cells use to move from one location to another,” said Michelle Dawson, an assistant professor in the School of Chemical and Biomolecular Engineering at the Georgia Institute of Technology…
Studies linking migraine to breast cancer have reported inconsistent results. …
Dr. Fatima Cardoso of the Champalimaud Clinical Center in Lisbon and coordinator of this study says, “This study aims to characterize the biology of this rare disease; only with this crucial knowledge will men with breast cancer be properly treated in the future, which will definitely improve both their survival and quality of life.” Of all cancers diagnosed in males, breast cancer accounts for less than one percent, and male breast cancer also accounts for less than one percent of all breast cancer diagnoses. …
The scientists say when activated, one protein, called the short form, stops glioblastoma cells from replicating their DNA, and the other, called the long form, prevents cell division if the DNA has already been replicated, explains Rebecca Riggins, PhD, assistant professor of oncology at Georgetown Lombardi. The study was posted online Dec…