Based on years of clinical observations, many symptoms of advanced thyroid no obvious symptoms, only occurs in the thyroid tissue mass in a rugged hard mass, the mass increases, up and down during swallowing lumps reduced mobility. If these two symptoms in the short term rapidly growing, many of undifferentiated carcinoma, often with advanced thyroid anti-nerve compression hose, tracheoesophageal produce hoarseness and swallowing difficulty breathing difficulties; such as compression of cervical sympathetic Hall that can generate comprehensive from the superficial branch of the cervical nerves are violated, patients may have ear pain pillow partial transfer of the shoulder so often in the neck, a hard and fixed lymph nodes; distant metastases more common in flat bones and lungs.
Late symptoms in undifferentiated thyroid carcinoma: anaplastic carcinoma, also known as anaplastic carcinoma, is a highly malignant tumor, accounting for 8% of thyroid cancer. The average age of onset is generally 60 years. The disease progressed rapidly to its main clinical features. Mass involving the adjacent tissues and organs occurs quickly hoarseness, coughing, swallowing difficulties and neck pain and other symptoms. Thyroid and neck examination shows a huge solid mass with diffuse, hard, fixed, ill-defined, widespread violations of the surrounding tissue. High rate of cervical lymph node metastasis, hematogenous metastasis often occurs.
Some patients with advanced thyroid symptoms are not obvious, only the neck bone metastasis of lung cancer as the prominent symptom, so when the neck bones are the primary lung tumor metastasis of unknown presence, the thyroid should be carefully examined. Different pathological types of thyroid cancer has its own clinical features of papillary carcinoma; the most common thyroid cancer accounts for about 60% – 70% of women and to teach patients more than 40 years of age, low grade, slow progression, from discovery to treatment time of 5 mass years accounted for 31.8%, duration of up to 20 years, tumors were single primary tumor can be very small high incidence of cervical lymph node metastasis, appeared early, a wide range of slow development, may have cystic degeneration, the prognosis Medullary carcinoma accounts for about a good 5% of the disease – 10% less common is often misdiagnosed as undifferentiated carcinoma, medullary thyroid cancer in thyroid nodules and the majority of treatment, duration of 10-20 days on average, some patients with cervical lymph node swelling of the treatment, most patients no special discomfort in some patients may have dysphagia, hoarseness, cough, dyspnea and other symptoms, symptoms of a small number of patients have distant metastases.
Late symptoms from thyroid parafollicular cells (C cells), can produce calcitonin (CT), prostaglandin (P), 5 by colored plastic (5-HT), vasoactive intestinal peptide (VIP) and so on. Patients may have diarrhea, facial flushing and sweating and other carcinoid syndrome or other endocrine disorders of the performance.