Treatment of common complications of breast cancer treatment

By | April 6, 2012

Treatment of common complications of breast cancer treatment (a) the prevention of hair loss
After chemotherapy, there will be a transient hair loss, to head the most common is when the common side effects of chemotherapy, after the incidence of nausea and vomiting. After chemotherapy, hair loss was first seen in 1 to 2 weeks, reached a peak after 2 months of chemotherapy to stop 1 to 2 months to start regeneration. Preventive measures:
1. Application of the gentle nature of protein-based shampoo, avoid using strong irritant shampoo.
2. Avoid using hair dryer, curling iron, hair gel, hair and too much hair.
3. Chemotherapy before the application of a tourniquet, ice caps, and other physical means to prevent hair loss.
Breast cancer treatment of common complications of treatment (II) on renal toxicity:
1. Chemotherapy before assessment of renal function, commonly used indicators of BUN, Cr, MG and so on.
2. For many years high blood pressure, diabetes, elderly patients, renal toxicity with caution or reducing the use strong chemotherapy drugs.
3. Use of DDP and other nephrotoxic drugs strong, requires the application before and after 6 hours to maintain urine output per hour 150 ~ 200ml, after 2 to 3 days more than 100ml per hour to maintain urine output; such as the chest, abdominal cavity water treatment of the need for 5 to 7 days.
4. Use the day before MTX hydration, alkalinization of urine (pH> 7.4) to 3 days after the end of chemotherapy, while monitoring the blood concentration.
5. For a larger tumor burden, chemotherapy-sensitive tumors were high-dose chemotherapy, while the drug combination to promote uric acid excretion.
6. Once renal dysfunction, while recommendations to use diuretics combined renal vasodilators, antioxidants, basic drugs, to keep the urine alkaline, and daily urine output should be greater than 3000ml.
Treatment of common complications of breast cancer treatment (c) Prevention of liver toxicity:
1. A comprehensive understanding of the history of patients per disease, liver function and viral hepatitis serology. Liver function in patients with a comprehensive assessment, the correct choice and dosage of chemotherapy drugs.
2. Can be 10% glucose, vitamin C and vitamin B, Glucurolactone, biphenyl pairs, such as the liver was healthy liver drug treatment.
3. Hepatic veno-occlusive disease currently no specific effective treatment, mainly symptomatic treatment, to maintain water balance, improve renal blood flow, proper use of diuretics, control encephalopathy. To try corticosteroids, prostaglandin E1 and low-dose heparin treatment.
Treatment of common complications of breast cancer treatment (d) endocrine therapy and treatment of drug toxicity, endocrine therapy for breast cancer side effects are relatively light.
1. Anti-estrogen drugs (such as tamoxifen) short-term side effects of nausea and hot flashes, transient thrombocytopenia; long-term toxicity of thrombosis, endometrial cancer, retinal degeneration.
Treatment: medication attention to the case of the endometrium, early detection and timely treatment; if there blurred vision, floaters should be discontinued.
2. Progestin drugs side effects of obesity, fluid leakage to stay, hyperglycemia, hypertension, liver damage.
3. The side effects of aromatase inhibition fatigue, headache, hot flashes, diarrhea, nausea, skin Yan and so on, occasional white blood cells, or thrombocytopenia, and permanent adrenal insufficiency, thrombosis; third-generation aromatase inhibitors may cause bone osteoporosis and increased fracture rate.
Treatment: bone mineral density should be monitored during the treatment; application lag to instantaneous acid (zoledronicacid) can prevent bone loss, osteoporosis, and reduce fractures.
4. Luteinizing hormone releasing hormone (LHRH) analogues and enantone Nuolei De side effects are the two commonly used LHRH drugs. Side effects include dizziness, headache, sweating, flushing, gynecomastia, hirsutism, skin Yan, decreased libido, edema. Adverse effects of androgens are mainly masculine symptoms in the medication after 2 ~ 3 months cancer sores, increased sebaceous secretion, hirsutism, hair loss, sound thicker and so, the withdrawal symptoms often go away.

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