Introduction of spindle cell carcinoma

By | March 28, 2012

Spindle cell carcinoma (spindle cell carcinoma): from a single spindle tumor cells of the cancer, known as spindle cell carcinoma, undifferentiated carcinoma are clinically very few areas of spindle tumor cells from a single form of lung cancer . The majority of spindle cell carcinoma as poorly differentiated adenocarcinoma, poorly differentiated squamous cell carcinoma, squamous cell carcinoma and poorly differentiated adeno carcinoma of the lung pleomorphic component.
Spindle cell carcinoma of the gross and microscopic Introduction: The tumor was gray, gray red or brown, ill-defined, easy to see necrosis and hemorrhage. Microscope, the tumor cells were spindle, polygonal, sizes, morphological diversity; vesicular nuclei, prominent nucleoli, mitotic extremely active, showing that pathological mitotic figures, diffuse infiltration of cancer cells, showing sarcomatoid growth.
spindle cell carcinoma of the introduction of immunohistochemistry: epithelial markers CK, EMA diffuse, strong positive expression.
introduction of spindle cell carcinoma spindle cell carcinoma: a. a single spindle tumor cells showed sarcoma-like growth; b. immunohistochemistry, epithelial markers CK, EMA showed diffuse, strong positive expression.
Spindle cell carcinoma of the introduction of multi-cell carcinoma in the differential diagnosis: cancer should be with the following differences:
a. Single-phase malignant mesothelioma: two similar morphological structure. Alone to distinguish between light microscopy, immunohistochemistry should be done. Mesothelioma, biphasic differentiation, so vimentin, EMA-positive tumor cells were clear; and spindle cell carcinoma, expression of epithelial marker antibodies. Only a few cancer cells of vimentin was weakly positive.
b. fibrosarcoma (fibrosarcoma): spindle cell carcinoma and fibrosarcoma in cell shape:, and the structure similar. When the spindle tumor cells, the epithelial markers CK, EMA was negative gray up, indicating a lack of cancer tumor cell differentiation. Do vimentin detection, positive-derived markers, tissue cell antigen marker, S-IOO protein were highly negative, continuously for a fibrosarcoma, spindle cell carcinoma is not.
c. Other: spindle cell carcinoma but also with smooth muscle sarcoma, inflammatory myofibroblastic state, malignant fibrous histiocytoma and malignant tumors of God differential distribution.

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