Introduction of giant cell carcinoma

By | March 28, 2012

Introduction of giant cell carcinoma (giant cell carcinoma): only by a high degree of polymorphism, multi-core and single core of giant cell tumor composed of large cell carcinoma, known as giant cell carcinoma. Giant cells, for fear that highly malignant tumors, and its general shape and pleomorphic carcinoma similar.
Giant cell carcinoma of the introduction of 1) pathological features: Microscopically, giant cell carcinoma has a characteristic histological structure: organization from a single core or multi-core, large, polygonal cells; cell size of the gap, eosinophil; cancer cells were discrete distribution, which is different from the normal density of cancer cells becoming quite out; cancer nuclear sizes, varied shapes, a higher degree of atypia, nuclear deep, prominent nucleoli; nuclear fission is easy to see visible pathological mitosis; cancer cells and cancer cells and can be seen among a large number of neutrophils and lymphocytes.
Once the mixture of giant cell carcinoma of the spindle cells and (or) any of the components of non-small cell lung cancer, the attributable pleomorphic carcinoma. If associated with small cell carcinoma, is called a composite of small cell carcinoma.
Giant cell carcinoma of the description 2) differential diagnosis: giant cell carcinoma with the following tumors.
pleomorphic carcinoma: pleomorphic carcinoma can sometimes occur large amounts of giant cells, spindle cells for the presence of small cell carcinoma but was concealed, can be diagnosed as giant cell carcinoma. Therefore, the diagnosis of giant cell carcinoma is a great all-bizarre tumor cells with marked inflammatory cell infiltration.
giant cell malignant fibrous histiocytoma (giant cell type of evil-fiber group): A point of identification: a. the evil giant cell complex fiber composition, in addition to giant cells and inflammatory cells, there was grain-like structure of the shuttle seats shaped cells, a single giant cell carcinoma of the components; b. evil giant cell-type fiber reactive groups often appear peripheral bone tissue, and giant cell carcinoma were not; c. evil giant-cell antigen-fiber group and the waveform of the organization protein was generally positive, CK and other epithelial markers were negative. Giant cell carcinoma of the opposite.
metastatic anaplastic thyroid cancer, giant cell carcinoma of the breast: differential diagnosis with the two key is to find the primary cancer, thyroid carcinoma and giant cell giant cell carcinoma of the breast, if lung metastasis, primary cancer of the organ should be obvious mass, and most of nodular metastases.

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