Esophageal cancer chemotherapy side effects of mitomycin

By | January 23, 2012

Mitomycin side effects (1) bone marrow suppression. For the most serious side effects, including platelets and white blood cells decreased significantly, especially the former, individual patient bleeding tendency and slow recovery. Intermittent dosing every 3-4 weeks through the methods and limitations in 10-20mg/ml Following a single dose can reduce the incidence of bone marrow suppression.
Mitomycin adverse events (2) liver and kidney dysfunction. Rare. It has been reported tubular necrosis after treatment, even uremia.
(3) gastrointestinal reactions. Some patients have loss of appetite, nausea, vomiting, mucositis and diarrhea, but generally less severe.
(4) may have intravenous injection of local inflammation, such as extravascular leakage can cause pain, tissue necrosis and ulceration.
Mitomycin side effects (5) skin and its appendages. Itching of skin cancer, skin erythema, formication, hand, foot and made the end of colonization of skin erosion occur, peeling, hardening, and hair loss. Wong dose-dependent skin toxicity.
(6) pulmonary toxicity. Showed lack of restrictive lung ventilation, the application of corticosteroid treatment is effective. Alveolitis and pulmonary fibrosis is more severe late side effects.
(7) bladder instillation can cause bladder inflammation and hematuria. Intrapleural injection of chemical pleurisy can occur.
Mitomycin side effects (8) reported cardiac toxicity of ADM, MMC increases, more common in the cumulative dose of MMC 55mg/ml (range 20-80mg/ml), severe congestive heart failure may occur.
(9) in the animal experiments have teratogenic effects, so as not pregnant.
Mitomycin side effects (10) there are other side effects headache, dizziness, drowsiness and fatigue. The drug can cause veno-occlusive disease, such as central venous and hepatic lobule hepatic vein occlusion, leading to jaundice, hepatomegaly, abdominal pain, ascites and hepatic encephalopathy.

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