Esophageal cancer chemotherapy drug mitomycin Notes

By | January 22, 2012

Mitomycin Note (1) MMC can cause leakage of extravascular tissue necrosis. In the event of leakage, should immediately stop injection site in the extravasation of 8.4% sodium bicarbonate injection and dexamethasone 5mg 5ml and do other processing.
(2), chloramphenicol, phenylbutazone, phenytoin can increase sales and other MMC's bone marrow suppression. MMC can increase the cardiac toxicity of ADM.
Mitomycin C Note (3) vitamin B2, vitamin B6, vitamin C, Cys, muscle past, ATP, sodium thiosulfate, etc. can increase the MMC inactivation in the liver.
(4) The drugs usually administered by intravenous injection, arterial injection and cavity can be injected, but can not be intramuscular or subcutaneous injection, although oral administration of the drug also absorbed, but low plasma concentrations, it is not for oral administration .
Mitomycin Note (5) as the medicine has delayed and cumulative bone marrow suppression, usually two courses of high dose application should be interval exceeds 6 weeks.
(6) of the dissolved drug should be used within the 4-6h.
Mitomycin Note (7) can be composed of the drug is mainly used for digestive tract cancer chemotherapy regimens: FAM (fluorouracil slightly Anhui, doxorubicin, mitomycin).

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