Endocrine therapy for prostate cancer

By | April 18, 2012

Most of the clinical prostate cancer is found in patients with advanced, advanced prostate cancer should be the preferred endocrine therapy, efficiency up to 80 %'-'- 100%. Endocrine therapy for prostate cancer can be directly against the androgen, inhibit the growth of prostate cancer. The more differentiated prostate cancer cells more like normal prostate androgen dependent, the better the efficacy of endocrine therapy. Undifferentiated carcinoma or ductal carcinoma often do not rely on male hormones, so the hormone therapy is not valid.
Commonly used endocrine therapy for prostate cancer methods:
1. Orchiectomy Bilateral orchiectomy is the most effective endocrine treatment, side effects minimal way, without the use of other auxiliary substances after the recent significant effect, long-term efficacy without metastasis 5-year survival was 31%, with metastasis 20%.
2. Estrogen drugs
Hexene female common hope, usage is: day 3 .-..- 5mg, used in conjunction 1'-"-3 weeks and daily maintenance dose of 1'-"-3mg, qd for 2 years. The main side effects are impotence, gastrointestinal reactions, severe cardiovascular disease, thrombophlebitis. Patients with cardiovascular disease should not be used.
3. Anti-androgen drugs
There are two types one by one commonly used steroids and non-steroid. Si corticosteroid luteal (each 100mg, 3 times a day), which a pregnant intoxicated (each 4mg, 2 times a day), non-steroid flunitrazepam kidding cool gel (brand name: flutamide, is the most important The non-steroidal anti-androgen drugs. Usage: Each 250mg, 3 times a day. flunitrazepam has been reported butyric cool glue application plus testosterone or gonadotropin-releasing hormone analogues resection can be achieved hormonal inhibition effect is more good. anti-androgen drugs also pay health lag and aminoglutethimide (amino derivative can sleep), but due to drug toxicity, side effects and poor efficacy, not widely used.
4. Luteinizing hormone releasing hormone analogues
Commonly used buserelin (500 bait, sc, 1 every 8 hours, 7 days to 200g per day for 1 month can be achieved after the drug to testis) and enantone (leuprorelin acetae) sustained release (per times 3. 75mg, l times every 4 weeks, subcutaneous, slow release of drug in the body.) However, after administration of these drugs for the first time the 1 —- 3 days, blood testosterone appears a transient rise, increasing the patient's symptoms temporarily, may be combined with paid health lag or flunitrazepam butyric discretion to reduce the early treatment of increased symptoms of adverse reactions. Gonadotropin-releasing hormone analogues has the advantage of fewer side effects and no cardiovascular complications, reversible after discontinuation of testicular function, it can also be used if the drug test for prostate cancer, androgen dependent.

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