Variant of large cell carcinoma – lymph-like carcinoma (lymphoepithelioma-like carcinoma, LELC): lung LELC is a rare, unique type of lung cancer . Is a variant of large cell carcinoma, and its main feature is cancer in the cancer nests or nest asked rich lymphoid cell infiltration.
Variant of large cell carcinoma – lymph-like carcinoma 1) the naked eye: more than a single lung nodule LELC, state more clearly, mostly round or oval, maximum diameter of 1-8cm, an average of 3.5cm. Section are mostly white, mostly accompanied with hemorrhage and necrosis.
Variant of large cell carcinoma – lymph-like carcinoma 2) Light microscopy: the majority of cases the typical LELC, the tissue is not divided with nasopharyngeal carcinoma subtype of vesicular cells similar to cancer cells were co-expressed as cell body-like aggregation state between cells is unclear, cells were round or oval, and a large, vacuolization, you can see 1-2 distinct eosinophilic nucleoli. Focal carcinoma, or large visible necrosis. Audit 3-25 months / 10HPF. In some cases cancer of focal spindle cell areas, see the individual cancer nest was on behalf of the hierarchy, but no cells or cell keratosis bridge. Between cancer cell infiltration. Tumor stroma is rich in lymphocytes, plasma cells, some lymphoid follicles. Some interstitial fibrosis associated with collagen of obvious or.
Variant of large cell carcinoma – lymph-like carcinoma 3) electron microscopy: the main features of the ultrastructure of the lung LELC cytoplasm of cancer cells seen in the tension of the original fiber, and desmosomes between cells can be seen, showing a squamous lung LELC juice of epithelial characteristics.
Variant of large cell carcinoma – lymph-like carcinoma 4) differential diagnosis
poorly differentiated squamous cell carcinoma: a. lung LELC are large cell carcinoma, large cell carcinoma with organizational characteristics, such as but not to the differentiation of squamous or glandular epithelium, while the number of poorly differentiated squamous cell carcinoma within the keratosis phenomenon can be fine; b. Cell Nuclear large, vacuolization, prominent nucleoli, cells were piles of bodies like aggregates, which is relatively poorly differentiated squamous cell carcinoma realm of clear, part of the area around the cancer nest see palisading of different cancer cells; c. Tumor stroma is rich in lymphocytes, plasma cells, and even cancer cells mixed together.
lymphoma: a small number of cases of lung cancer cells scattered LEIC required to identify and lymphoma, the first section more carefully to find whether the formation of cancer nests; followed by immunohistochemistry, it is easy to make a diagnosis.
Variant of large cell carcinoma – lymph-like carcinoma 5) prognosis: the current data show that this type of lung cancer compared with good prognosis. Prognostic factors, and tumor recurrence and the degree of necrosis.