Characteristics of lung cancer Introduction

By | March 30, 2012

Lung cancer (adenocarcinoma) is the lung (bronchial) epithelial cancer. Adenoid differentiation of tumor cells or cancer cells secrete mucus. Tumor tissue can be presented alveolar (acinar), papillary (papillary), bronchioloalveolar-like (bro with hioloalveolar), solid structure with mucus formation (solid with mucin formation) or the various types of mixing.
Adenocarcinoma of lung cancer histological types in common.
Prognosis of lung adenocarcinoma than squamous cell carcinoma is good, but slightly better than the small cell lung cancer. Poor prognosis of lung cancer, the early invasive cancer tissue to the blood vessels prone to distant metastasis. Second, because most are peripheral lung cancer early in patients without obvious clinical symptoms, it is a symptoms, most radical of the time lost. Lung cancer occurs mainly in the peripheral lung, occurred in the central area of lung is rare.
Characteristics of lung cancer described (1) general pathological features: peripheral lung cancer, accounting for 70% -80% of lung cancer, mainly in the bronchioles of less than 3mm. If the adjacent lung membrane, the fibers cause lung membrane thickness, shrinkage forming depression. Off-white tumor, according to the different mucus, plastic dolphin-like appearance; tumor may contain carbon dust, light brownish-black spots, while in the whole thing black. If the tumor is larger around the boundaries clear, star-shaped infiltration of the lungs, the central area of necrosis often easy to trace the formation of epilepsy, but rarely form a hollow.
Characteristics of lung cancer described (2) under the electron microscope the main thing in common lung cancer: performance of the external cavity with cells, intracellular mucus granules; may have secretion phenomenon, well-developed endoplasmic reticulum, Golgi complex and the aircraft body, occasionally desmosomes, but no tension of the original fibers.
Characteristics of lung cancer described (3) immunohistochemistry: Cancer of the CEA response was stronger than cytokeratin (CK). According to the information, adenocarcinoma was 100% CEA, cytokeratin, 63.2%, this difference is significant.
Characteristics of lung cancer described (4), histological type: the more complex structure of lung cancer, according to WHO (1999) outside the histological classification of lung cancer can be divided into five subtypes and five variants.
Characteristics of lung cancer described (5), histological grade of adenocarcinoma: lung cancer among different types often mixed with each other, that is, the same histological type of differentiation may also be present in varying degrees. According to the degree of cell differentiation and tissue structural characteristics of the lung is divided into adenocarcinoma, moderately differentiated adenocarcinoma and poorly differentiated adenocarcinoma. Such as bronchioloalveolar carcinoma, differentiated fetal adenocarcinoma, mucinous (colloid) adenocarcinoma, mucinous cystadenocarcinoma is well differentiated adenocarcinoma; and solid adenocarcinoma with mucus formation, cell carcinoma and clear cell carcinoma to belong to the low differentiated adenocarcinoma.


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