Research on new anticancer drugs

By | December 8, 2011

Some people think that the proliferation of cancer cells faster than normal cells, where the rapid proliferation of cancer cells to the killing effects of drugs can be used as anti-cancer drug. In recent years has made it clear, hematopoietic cells and epithelial cell proliferation rate faster than the tumor cells. This suggests cytotoxic drugs although effective, but it will inevitably affect the normal cells, especially strong division, giving the patients have serious side effects. Successful anticancer drug Taxol study, indicating that the effects continue to look for a new and unique mechanism and targets of the chemical structure of drugs is important. However, the scope of its research and development should not be limited to the traditional components of the target nucleic acid and cytotoxic drugs. In the search for cancer drug's strategy to diversify. Particular focus on the mechanism of action based on new research and new molecular targets and new drugs on the chemical structure to compensate for the disadvantages of traditional chemotherapy drugs. Ideas and research in new drug screening methods have been updated and improved to take full advantage of new discoveries in molecular biology and new results. Study of synthetic drugs should be emphasized that the biochemical mechanism of action from the drug, and in vivo molecular target for the design process with new routes, not the pursuit of quantity of compounds, molecular modeling computer design can significantly improve efficiency.
Continue to have signs of unilateral and compound Chinese herbal medicine research, identify new anticancer drugs. Anti-cancer medicine has been successful research should further investigate the mechanism, to identify the targets of as much as possible, from the whole organ, cellular and molecular levels to clarify the efficacy of different mechanisms for the development of effective drugs to create a new generation of better conditions and provide new ideas. The study of anticancer drugs and screening for other than the above aspects, should also enhance the marine life, tropical rain forest plants and a variety of microorganisms in soil and water filter; establish and improve the speed, trace, and automated drug screening system in vitro. Gene chips currently used in high-throughput screening platform, will contribute significantly to pilot a new target for anti-cancer substances found. Create a variety of mouse models bearing human cancer, and further features of simulated human cancer, to search for different human tumors such as lung, colon, liver and ovarian cancer, and other effective drugs, the real from the "drug based" filter to "disease standard "filter changes.
Cellular and molecular biology, and technology continues to evolve, the tumor cells found in the process of malignant transformation and regulation of many of the key new target for anti-cancer drug research open in a new situation. Biological response modifiers and differentiation inducers, the primary monoclonal antibody directed therapy, anti-microtubule agents, topoisomerase inhibitors, anti-drug and anti-metastasis drugs such signals are introduced in the clinical application.
Established based on the theory of apoptosis combined suicide gene therapy targeting cancer chemotherapy research has entered clinical trials with antisense oligonucleotides "closed" or inhibition of cancer gene expression will cure cancer possible. The fundamental purpose of cancer research is to reduce mortality and morbidity. Mortality reduction depends mainly on treatment and prevention depends on reducing the incidence. Treatment depends on the past that drug prevention is a matter epidemiologist. This view is outdated. Now know that cancer is a specific disease; not only the treatment can not do without drugs, its prevention is inseparable from drugs, but also a promising means. This is because the transition from normal tissue have been pre-cancerous stage of cancer generally, and precancerous conditions of the cancer process is ideal target for cancer prevention drugs. Clinical studies have shown that dimensional gel acid on oral leukoplakia, cervical dysplasia significant effect. High Risk of esophageal cancer among high-risk intervention trial also proved enzyme-dimensional gel can reduce the incidence of esophageal cancer, and side effects are very small.
In short, the anti-cancer drugs, although only a few decades of the history, progress is very rapid, has now entered a new stage of development. It is facing the theory of updates, technology updates and ideas for updates. I believe that with new technology, wide application of new theory and the mutual penetration between disciplines, research anti-cancer drugs will be greater development.

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