Although no fixed threshold is defined for the UK, in practice, the National Institute for Clinical Excellence (NICE) guidelines suggest that patients need to have symptoms which indicate a five per cent risk or higher before further tests for most cancers are carried out. In the UK, one in three people in the UK will develop cancer during their lifetime…
The study, which includes patient data from five U.S. medical centers, is the largest of its kind. The study is published online ahead of print in European Urology, the journal of the European Association of Urology…
Despite similar results on objective assessments, "It appears that there is a difference in the perception of cosmetic outcomes between Caucasian and African-American patients," according to the study led by ASPS Member Surgeon Dr. Robert D. …
Prostate cancer is the most commonly diagnosed malignancy and the second most common cause of cancer-related deaths in men worldwide. In Finland, more than 4,000 new cases are diagnosed every year. The human genome is mainly identical throughout the human population worldwide. However, millions of small variations or polymorphisms, often located in a single nucleotide, can be found between individuals. …
The technique, which is described in the latest edition of IOP Publishing’s journal Physical Biology, works by identifying circulating endothelial cells (CECs) and has been successful in distinguishing patients undergoing treatment for a recent heart attack with a healthy control group. The researchers believe the technique can now be tested on patients who exhibit symptoms but are yet to experience a heart attack. …
Malignant melanoma is the fifth most common cancer in men and the sixth most common cancer in women, and its incidence rate is increasing rapidly. It accounts for nearly 80 percent of all deaths related to cutaneous cancer. When discovered early, localized melanoma can be cured by surgical removal. However, this cancer displays a strong tendency to metastasize and has very low survival rates for patients, with fewer than five percent surviving longer than five years. …
The study used mathematical models to calculate the long-term effect of the seminal report, and subsequent anti-smoking measures, over the past half-century. These cumulative efforts have significantly reshaped public attitudes and behaviors concerning cigarettes and other forms of tobacco, note the researchers. First author Theodore R…
The study, published today in Developmental Cell, describes a number of routes to the formation of a microtubule spindle — the tracks along which DNA moves when a cell divides in order to make two genetically identical cells. In order to understand the phenomenon, the authors, including Biosciences researchers Dr…
"Genetic mutations do not drive this mechanism," said Alana Welm, PhD, senior author of the study, associate professor in the Department of Oncological Sciences, and an investigator at Huntsman Cancer Institute. "Instead, it’s improper regulation of when genes turn on and off." The new discovery focuses on a protein called RON kinase (RON), which signals some areas of tumor cell DNA to become active…
In the study, published online in Cell Reports, scientists found that inhibiting the action of a protein called BRD4 caused cancer cells to die in a mouse model of malignant peripheral nerve sheath tumors (MPNSTs). "This study identifies a potential new therapeutic target to combat MPNST, an incurable type of cancer that is typically fatal," said Dr. …